DNA extraction on bio-chip: history and preeminence over conventional and solid-phase extraction methods

Ayoib A 1 , Hashim U 2 , Gopinath SCB 3 , Md Arshad MK 3

Affiliations 

  • 1 Ganoderma Research Group, Institute of Nano Electronic Engineering, University Malaysia Perlis, 01000, Kangar, Malaysia. adilahayoib@gmail.com
  • 2 Ganoderma Research Group, Institute of Nano Electronic Engineering, University Malaysia Perlis, 01000, Kangar, Malaysia. uda@unimap.edu.my
  • 3 Ganoderma Research Group, Institute of Nano Electronic Engineering, University Malaysia Perlis, 01000, Kangar, Malaysia
Appl Microbiol Biotechnol, 2017 Nov;101(22):8077-8088.
PMID: 28942548 DOI: 10.1007/s00253-017-8493-0

Abstract

This review covers a developmental progression on early to modern taxonomy at cellular level following the advent of electron microscopy and the advancement in deoxyribonucleic acid (DNA) extraction for expatiation of biological classification at DNA level. Here, we discuss the fundamental values of conventional chemical methods of DNA extraction using liquid/liquid extraction (LLE) followed by development of solid-phase extraction (SPE) methods, as well as recent advances in microfluidics device-based system for DNA extraction on-chip. We also discuss the importance of DNA extraction as well as the advantages over conventional chemical methods, and how Lab-on-a-Chip (LOC) system plays a crucial role for the future achievements.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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