Prognostic role of Oct4, CD44 and c-Myc in radio-chemo-resistant oral cancer patients and their tumourigenic potential in immunodeficient mice

Sawant S 1 , Gokulan R 2 , Dongre H 3 , Vaidya M 3 , Chaukar D 4 , Prabhash K 5 Show all authors , Ingle A 6 , Joshi S 3 , Dange P 7 , Joshi S 8 , Singh AK 3 , Makani V 9 , Sharma S 4 , Jeyaram A 10 , Kane S 11 , D'Cruz A 4

Affiliations 

  • 1 Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410 210, Maharashtra, India. sssawant@actrec.gov.in
  • 2 Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410 210, Maharashtra, India
  • 4 Head and Neck Unit, Tata Memorial Hospital (TMH), Parel, Mumbai, 400 012, India
  • 5 Medical Oncology Unit, Tata Memorial Hospital (TMH), Parel, Mumbai, 400 012, India
  • 6 Laboratory Animal Facility, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410 210, Maharashtra, India
  • 7 Sarin Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410 210, Maharashtra, India
  • 8 Department of Biology, University of Kentucky, 101 TH Morgan Building, Lexington, KY, 40506, USA
  • 9 Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Govindpura 462023, Bhopal, Madhya Pradesh, India
  • 10 Microbiology Laboratory, 12A, Cowley Brown Road (East), R.S. Puram, Coimbatore, 641 002, Tamilnadu, India
  • 11 Pathology Department, Tata Memorial Hospital (TMH), Parel, Mumbai, 400 012, India
Clin Oral Investig, 2016 Jan;20(1):43-56.
PMID: 25914047 DOI: 10.1007/s00784-015-1476-6

Abstract

In the present study, we have investigated the prognostic value of known stem cell-associated molecules such as Oct4, CD44 and c-Myc in patients with oral SCC who had received post-surgery radio- and/or chemotherapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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