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HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia

Herlyani Khosama 1 , Astri Budikayanti 1 , Amy Hui Ping Khor 2 , Lim, Kheng Seang 2 , Ng, Ching-Ching 2 , Indra G. Mansyur 1 Show all authors , Alida Harahap 3 , Teguh A.R. Ranakusuma 1 , Tan, Chong Tin 2

Affiliations 

  • 1 University of Indonesia
  • 2 University of Malaya
  • 3 Eijkman Institute
Neurology Asia, 2017;22(2):113-116.
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Abstract

Background & Objective: Association between HLA-B*1502 and carbamazepine-induced StevenJohnson
syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian
populations but not in Indonesian. The purpose of this study was to evaluate the association between
HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population.

Methods: Patients with history of
CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was
performed.

Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502
was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035).

Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.

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