Displaying publications 1 - 20 of 1151 in total

    Trans. R. Soc. Trop. Med. Hyg., 1959 Nov;53:534-5.
    PMID: 13841618
    Matched MeSH terms: Asian Continental Ancestry Group*
  2. Ramli Musa, Mat Aris MA, Draman S, Abdullah K, Bujang MA
    All available family scales are designed for western countries and there is no validated
    family scale which is specifically devised for Asian population. The difference in culture and family values warrants the formulation of a specific Asian family scale to cater the regional needs. The objectives are to devise and validate a new family scale and eventually to validate it for Malaysian population.
    Matched MeSH terms: Asian Continental Ancestry Group
  3. Ismail E, Amini F, Abdul Razak S, Mohd Zaini H, Alwi Z, Farhour R
    Sains Malaysiana, 2013;42:921-926.
    Negritos of Peninsular Malaysia have physical features which strongly resemble the African pygmies rather than any of the other main South East Asian ethnic groups. In addition, their features are also completely different from the two other large sub-groups of the Peninsular Malaysia Orang Asli, i.e. Senoi and Proto-Malay. In this study, we genetically screened three African-specific markers, Glucose-6 Phosphate Dehydrogenase (G6PD) gene PvuII Type 2 polymorphism and A- mutation; and Sickle Cell trait in 103 unrelated individuals with G6PD deficiency. None of the Negritos’ samples carried A- and Sickle cell mutations but all males and females have the PvuII Type 2 polymorphism. The same results were seen in all DNA samples of the Malaysian’s Malay, Chinese and Indians. Additionally, all females in this study were homozygous for PvuII Type 2 polymorphism. Thus, we concluded that this polymorphism is widespread in all Malaysian population and is not unique to just Africans. However, these findings indicated that the polymorphism was widely conserved and can be used to study the African descendant in any world population hitherto supporting the ‘Out of Africa’ theory.
    Matched MeSH terms: Asian Continental Ancestry Group
  4. Ryrie GA
    Lepr Rev, 1948 Jan;19(1):4-11.
    PMID: 18908067
    This is an interesting comparison between the types of leprosy seen among Chinese, Malays and Indians in Malaya, based on a large experience. The disease is most virulent among Chinese and least so among Indians, three-fourths of the cases among the latter being of mild tuberculoid disease with a tendency to self-healing, but among the Chinese only one-third are of the tuberculoid type. The climate of Malaya is of the hot humid type, in which leprosy flourishes. On the other hand, a higher standard of living than in India tends to hinder the spread of the disease. The age incidence is important. Among, the Chinese, early macules are commonly found in children of 5 to 15 years of age, most of which tend to clear up, but in about one-fourth tuberculoid lesions develop and may go on to the lepromatous condition, especially if the onset of the tuberculoid stage occurs early. When a reliable history is obtained in Chinese, in nearly every lepromatous case a tuberculoid stage was first observed, commonly in the age group 16-40. In a smaller number of persons of over 40 years of age, the proportion of tuberculoid cases is very much higher, but the tendency to become lepromatous is very much less. Major tuberculoid cases are more liable than minor to become lepromatous, but nerve thickening in tuberculoid leprosy is less evident in Chinese than in Indians and it is rare in children and in those over 40. In view of the foregoing peculiarity of the evolution of leprosy in tuberculoid cases in Chinese subjects, active treatment is necessary, in order to prevent them becoming lepromatous. For this purpose, intradermal injections are of little value and they tend to obscure any evolutionary changes. Hydnocarpus oil or esters (deep subcutaneous injections) should therefore be pushed to the limit of tolerance in doses of 1 cc. per 10 pounds body weight twice weekly, or 30 cc. per week, for a patient of 150 Ibs. as a minimum and increased by at least fifty per cent, in acute or reacting cases, when improvement may be expected within three months. Some years' experience of this intensive treatment as compared with weekly injections of 1-5 cc. has shown much more marked improvement and much less incidence of lepromatous change with the high doses. In lepromatous cases, reactions should be avoided, but dosage should be as high as possible short of producing increased erythrocyte sedimentation and plantar pain on heavy stroking. Surveys of school children are of great importance in finding the early macular stage and their discovery may lead to the detection of infective adults who require to be segregated. L. Rogers.
    Matched MeSH terms: Asian Continental Ancestry Group*
    Med J Malaya, 1958 Dec;13(2):153-8.
    PMID: 13632213
    Matched MeSH terms: Asian Continental Ancestry Group*
    Med J Malaya, 1962 Mar;16:184-92.
    PMID: 14462716
    Matched MeSH terms: Asian Continental Ancestry Group*
  7. VELLA F
    Med J Malaya, 1958 Jun;12(4):602-4.
    PMID: 13577152
    Matched MeSH terms: Asian Continental Ancestry Group*
    Med. J. Malaysia, 1964 Jun;18:219-22.
    PMID: 14199436
    Matched MeSH terms: Asian Continental Ancestry Group*
    Med J Malaya, 1960 Mar;14:177-80.
    PMID: 13770937
    Matched MeSH terms: Asian Continental Ancestry Group*
    Jpn. J. Med. Sci. Biol., 1952 Dec;5(6):425-32.
    PMID: 13069136
    Matched MeSH terms: Asian Continental Ancestry Group*
  11. CHONG YH
    Med J Malaya, 1961 Dec;16:136-43.
    PMID: 13879161
    Matched MeSH terms: Asian Continental Ancestry Group*
  12. Eng LI, Bolton JM, Fudenberg HH
    Nature, 1967 Aug 12;215(5102):777.
    PMID: 4168452
    Matched MeSH terms: Asian Continental Ancestry Group*
    Med J Malaya, 1961 Mar;15:97-101.
    PMID: 13883856
    Matched MeSH terms: Asian Continental Ancestry Group*
  14. MILLIS J
    Med J Malaya, 1958 Dec;13(2):145-52.
    PMID: 13632212
    Matched MeSH terms: Asian Continental Ancestry Group*
  15. KHOO FY
    Med J Malaya, 1955 Jun;9(4):281-3.
    PMID: 13253128
    Matched MeSH terms: Asian Continental Ancestry Group*
  16. Musa RH, Muhamad NA, Hassan A, Ayob Y, Yusoff NM
    Asian J Transfus Sci, 2015 Jan-Jun;9(1):48-54.
    PMID: 25722573 DOI: 10.4103/0973-6247.150951
    Rh molecular studies have been previously mainly conducted in Caucasians and African population. There is a limited data on the molecular basis for Rh genotypes among Asians.
    Matched MeSH terms: Asian Continental Ancestry Group
  17. Chin WC, Zaidi Isa
    This research investigated the unit-root tests using nonparametric sequences-reversals (S-R), Phillip-Perron (PP) tests and parametric Augmented Dickey-Fuller (ADF) test for the Malaysian equity indices. Under the considerations of drift and structural break, it was found that during the restructuring period after the Asian financial crisis, most of the indices provided evidences against the unit-root tests. These results are somewhat contrasted with the conventional unit-root tests that ignored the impact of structural changes. In addition, the S-R tests were found to have little power to identify the deviations from the unit-root even after the inclusion of structural break.
    Matched MeSH terms: Asian Continental Ancestry Group
  18. NurWaliyuddin HZ, Norazmi MN, Edinur HA, Chambers GK, Panneerchelvam S, Zafarina Z
    PLoS ONE, 2015;10(11):e0141536.
    PMID: 26565719 DOI: 10.1371/journal.pone.0141536
    The aboriginal populations of Peninsular Malaysia, also known as Orang Asli (OA), comprise three major groups; Semang, Senoi and Proto-Malays. Here, we analyzed for the first time KIR gene polymorphisms for 167 OA individuals, including those from four smallest OA subgroups (Che Wong, Orang Kanaq, Lanoh and Kensiu) using polymerase chain reaction-sequence specific primer (PCR-SSP) analyses. The observed distribution of KIR profiles of OA is heterogenous; Haplotype B is the most frequent in the Semang subgroups (especially Batek) while Haplotype A is the most common type in the Senoi. The Semang subgroups were clustered together with the Africans, Indians, Papuans and Australian Aborigines in a principal component analysis (PCA) plot and shared many common genotypes (AB6, BB71, BB73 and BB159) observed in these other populations. Given that these populations also display high frequencies of Haplotype B, it is interesting to speculate that Haplotype B may be generally more frequent in ancient populations. In contrast, the two Senoi subgroups, Che Wong and Semai are displaced toward Southeast Asian and African populations in the PCA scatter plot, respectively. Orang Kanaq, the smallest and the most endangered of all OA subgroups, has lost some degree of genetic variation, as shown by their relatively high frequency of the AB2 genotype (0.73) and a total absence of KIR2DL2 and KIR2DS2 genes. Orang Kanaq tradition that strictly prohibits intermarriage with outsiders seems to have posed a serious threat to their survival. This present survey is a demonstration of the value of KIR polymorphisms in elucidating genetic relationships among human populations.
    Matched MeSH terms: Asian Continental Ancestry Group/genetics
  19. Say YH, Ban ZL, Arumugam Y, Kaur T, Tan ML, Chia PP, et al.
    J. Biosci., 2014 Dec;39(5):867-75.
    PMID: 25431415
    This study investigated the association of Uncoupling Protein 2 gene (UCP2) 45-bp I/D polymorphism with obesity and adiposity in 926 Malaysian subjects (416 males;265 obese; 102/672/152 Malays/Chinese/Indians). The overall minor allele frequency (MAF) was 0.14, while MAFs according to Malay/Chinese/Indian were 0.17/0.12/0.21. The polymorphism was associated with ethnicity, obesity and overall adiposity (total body fat percentage, TBF), but not gender and central adiposity (waist-hip ratio, WHR). Gender- and ethnicity-stratified analysis revealed that within males, the polymorphism was not associated with ethnicity and anthropometric classes. However, within females, significantly more Indians, obese and those with high TBF carried I allele. Logistic regression analysis among females further showed the polymorphism was associated with obesity and overall adiposity; however, when adjusted for age and ethnicity, this association was abolished for obesity but remained significant for overall adiposity [Odds Ratio (OR) for ID genotype = 2.02 (CI=1.18, 3.45; p=0.01); I allele =1.81 (CI=1.15, 2.84; p=0.01)]. Indeed, covariate analysis controlling for age and ethnicity also showed that those carrying ID genotype or I allele had significantly higher TBF than the rest. In conclusion, UCP2 45-bp I/D polymorphism is associated with overall adiposity among Malaysian women.
    Matched MeSH terms: Asian Continental Ancestry Group/genetics
  20. Aghakhanian F, Yunus Y, Naidu R, Jinam T, Manica A, Hoh BP, et al.
    Genome Biol Evol, 2015 May;7(5):1206-15.
    PMID: 25877615 DOI: 10.1093/gbe/evv065
    Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history of these populations remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in three major groups of Negrito, Senoi, and Proto-Malay. Structural analyses indicated that although all OA groups are genetically closest to East Asian (EA) populations, they are substantially distinct. We identified a genetic affinity between Andamanese and Malaysian Negritos which may suggest an ancient link between these two groups. We also showed that Senoi and Proto-Malay may be admixtures between Negrito and EA populations. Formal admixture tests provided evidence of gene flow between Austro-Asiatic-speaking OAs and populations from Southeast Asia (SEA) and South China which suggest a widespread presence of these people in SEA before Austronesian expansion. Elevated linkage disequilibrium (LD) and enriched homozygosity found in OAs reflect isolation and bottlenecks experienced. Estimates based on Ne and LD indicated that these populations diverged from East Asians during the late Pleistocene (14.5 to 8 KYA). The continuum in divergence time from Negritos to Senoi and Proto-Malay in combination with ancestral markers provides evidences of multiple waves of migration into SEA starting with the first Out-of-Africa dispersals followed by Early Train and subsequent Austronesian expansions.
    Matched MeSH terms: Asian Continental Ancestry Group/genetics*
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