The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease

Eslam M 1 , Sarin SK 2 , Wong VW 3 , Fan JG 4 , Kawaguchi T 5 , Ahn SH 6 Show all authors , Zheng MH 7 , Shiha G 8 , Yilmaz Y 9 , Gani R 10 , Alam S 11 , Dan YY 12 , Kao JH 13 , Hamid S 14 , Cua IH 15 , Chan WK 16 , Payawal D 17 , Tan SS 18 , Tanwandee T 19 , Adams LA 20 , Kumar M 21 , Omata M 22 , George J 23

Affiliations 

  • 1 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, 2145, Australia. mohammed.eslam@sydney.edu.au
  • 2 Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. shivsarin@gmail.com
  • 3 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
  • 4 Center for Fatty Liver, Department of Gastroenterology, Xin Hua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai, China
  • 5 Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
  • 6 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
  • 7 Department of Hepatology, MAFLD Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  • 8 Hepatology and Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  • 9 Department of Gastroenterology, School of Medicine, Marmara University, Istanbul, Turkey
  • 10 Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Pangeran Diponegoro Road No. 71st, Central Jakarta, 10430, Indonesia
  • 11 Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
  • 12 Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore
  • 13 Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, National Taiwan University, 1 Chang-Te Street, Taipei, 10002, Taiwan
  • 14 Department of Medicine, Aga Khan University, Karachi, Pakistan
  • 15 Institute of Digestive and Liver Diseases, St. Luke's Medical Center, Global City, Philippines
  • 16 Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 17 Department of Medicine, Cardinal Santos Medical Center, Mandaluyong, Philippines
  • 18 Department of Hepatology, Selayang Hospital, Batu Caves, Malaysia
  • 19 Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • 20 Medical School, Faculty of Medicine and Health Sciences, The University of Western Australia, Nedlands, WA, Australia
  • 21 Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India
  • 22 Department of Gastroenterology, Yamanashi Central Hospital, Yamanashi, Japan
  • 23 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, 2145, Australia. jacob.george@sydney.edu.au
Hepatol Int, 2020 Dec;14(6):889-919.
PMID: 33006093 DOI: 10.1007/s12072-020-10094-2

Abstract

Metabolic associated fatty liver disease (MAFLD) is the principal worldwide cause of liver disease and affects nearly a quarter of the global population. The objective of this work was to present the clinical practice guidelines of the Asian Pacific Association for the Study of the Liver (APASL) on MAFLD. The guidelines cover various aspects of MAFLD including its epidemiology, diagnosis, screening, assessment, and treatment. The document is intended for practical use and for setting the stage for advancing clinical practice, knowledge, and research of MAFLD in adults, with specific reference to special groups as necessary. The guidelines also seek to improve patient care and awareness of the disease and assist stakeholders in the decision-making process by providing evidence-based data. The guidelines take into consideration the burden of clinical management for the healthcare sector.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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