Work-related musculoskeletal disorders of the upper limb (WRMSDs-UL) account for one of the largest types of occupational disorders worldwide. This broad term includes several disorders, such as carpal tunnel syndrome, tendonitis, tension neck syndrome and lateral epicondylitis (tennis elbow) which are generally caused by poor postures, repetitive strain and psychosocial factors. Various workplace interventions have been investigated and employed to prevent the different WRMSDs-UL, but a common consensus to address the problem has yet to be achieved. This paper reviews and discusses the efficacies of some interventions which have been tested for the most prevalent type of WRMSDs-UL, carpal tunnel syndrome (CTS). The focus will be on computer users who developed CTS out of the prolonged and repetitive use of keyboards and pointing devices. The interventions studied include engineering design, management strategies, personal development, medical treatment and multi-dimensional approaches. Outcome of the study reveals that the most effective approach would be one that is multi-dimensional in nature, with the inclusion of at least two or more intervention strategies at the same time.