Affiliations 

  • 1 Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia; Malaysian Agricultural Research and Development Institute, 43400 Serdang, Selangor, Malaysia. Electronic address: nazrul@mardi.gov.my
  • 2 Institute of Science, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia. Electronic address: agustono@salam.uitm.edu.my
  • 3 Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia; Malaysia Institute of Transport, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia. Electronic address: noriham985@salam.uitm.edu.my
  • 4 Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia; Atta-ur-Rahman Institute for Natural Products Discovery (AuRins), Universiti Teknologi MARA, 42300 Bandar Puncak Alam, Selangor, Malaysia. Electronic address: rohayaahmad@salam.uitm.edu.my
Food Chem, 2018 Nov 15;266:200-214.
PMID: 30381177 DOI: 10.1016/j.foodchem.2018.05.120

Abstract

We have previously reported on the antioxidant potential of Artocarpus heterophyllus J33 (AhJ33) variety fruit waste from different extraction methods. In the study, the rind maceration extract (RDM) exhibited the highest phenolic and polyphenolic contents and strongest antioxidant potential measured by the DPPH assay (R2 = 0.99). In this paper, we now report on the bioassay-guided fractionation of the active ethyl acetate (EtOAC) fraction of RDM and its TOF-LCMS analysis. Seven sub-fractions resulting from the chromatographic separation of the EtOAC fraction showed radical scavenging activities between 80 and 94% inhibition. Subsequent LCMS analysis led to the identification of fifteen compounds comprising 5 phenolics and 10 non-phenolic compounds, 11 of which are reported for the first time from AhJ33 variety. Most of the identified compounds have been reported to possess antioxidant activity in many previous studies. This indicates that AhJ33 is a promising source of antioxidants for the development of food and nutraceutical products.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.