Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells

Fadaeinasab M 1 , Karimian H 2 , Omar H 3 , Taha H 4 , Khorasani A 5 , Banisalam B 5 Show all authors , Aziz Ketuly K 6 , Abdullah Z 1

Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
  • 2 School of Medicine, Taylor's University, Subang Jaya Selangor 47500, Malaysia
  • 3 Centre for Foundation Studies in Science, Division of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia
  • 4 Institute of Energy Infrastructure, Universiti Tenaga Nasional, Kajang 43000, Malaysia
  • 5 Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
  • 6 Department of Medical Chemistry, College of Medicine, University of Duhok, Duhok 78, Kurdistan Region, Iraq
J Asian Nat Prod Res, 2020 May;22(5):474-488.
PMID: 30945944 DOI: 10.1080/10286020.2019.1588888

Abstract

One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC50 value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile.

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