Parkinson's disease in the Western Pacific Region

Lim SY 1 , Tan AH 2 , Ahmad-Annuar A 3 , Klein C 4 , Tan LCS 5 , Rosales RL 6 Show all authors , Bhidayasiri R 7 , Wu YR 8 , Shang HF 9 , Evans AH 10 , Pal PK 11 , Hattori N 12 , Tan CT 2 , Jeon B 13 , Tan EK 5 , Lang AE 14

Affiliations 

  • 1 Division of Neurology, Department of Medicine, and the Mah Pooi Soo and Tan Chin Nam Centre for Parkinson's and Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: sylim@ummc.edu.my
  • 2 Division of Neurology, Department of Medicine, and the Mah Pooi Soo and Tan Chin Nam Centre for Parkinson's and Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
  • 5 Department of Neurology, National Neuroscience Institute, Singapore
  • 6 Department of Neurology and Psychiatry, University of Santo Tomas Hospital, Manila, Philippines
  • 7 Chulalongkorn Center of Excellence for Parkinson's Disease and Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
  • 8 Department of Neurology, Linkou Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
  • 9 Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
  • 10 Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia
  • 11 Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
  • 12 Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
  • 13 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea
  • 14 Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
Lancet Neurol, 2019 09;18(9):865-879.
PMID: 31175000 DOI: 10.1016/S1474-4422(19)30195-4

Abstract

1·8 billion people of diverse ethnicities and cultures live in the Western Pacific Region. The increasing longevity of populations in this region is a major contributor to the exponential increase in Parkinson's disease prevalence worldwide. Differences exist between Parkinson's disease in the Western Pacific Region and in Europe and North America that might provide important insights into our understanding of the disease and approaches to management. For example, some genetic factors (such as LRRK2 mutations or variants) differ, environmental exposures might play differential roles in modulating the risk of Parkinson's disease, and fewer dyskinesias are reported, with some differences in the profile of non-motor symptoms and comorbidities. Gaps in awareness of the disease and inequitable access to treatments pose challenges. Further improvements in infrastructure, clinical governance, and services, and concerted collaborative efforts in training and research, including greater representation of the Western Pacific Region in clinical trials, will improve care of patients with Parkinson's disease in this region and beyond.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications