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Diagnosis and management of latent tuberculosis infection in Asia: Review of current status and challenges

Paton NI 1 , Borand L 2 , Benedicto J 3 , Kyi MM 4 , Mahmud AM 5 , Norazmi MN 6 Show all authors , Sharma N 7 , Chuchottaworn C 8 , Huang YW 9 , Kaswandani N 10 , Le Van H 11 , Lui GCY 12 , Mao TE 13

Affiliations 

  • 1 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: nick_paton@nuhs.edu.sg
  • 2 Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia. Electronic address: lborand@pasteur-kh.org
  • 3 Department of Internal Medicine, Adult Pulmonary Medicine, Philippine General Hospital, Manila, Philippines
  • 4 Insein General Hospital, Department of Medicine, University of Medicine (2), Yangon, Myanmar
  • 5 Department of Respiratory Medicine, Asgar Ali Hospital, Dhaka, Bangladesh
  • 6 School of Health Sciences, Universiti Sains Malaysia, Malaysia
  • 7 Department of Community Medicine, Maulana Azad Medical College, New Delhi, India
  • 8 Department of Disease control, Ministry of Public Health, Thailand
  • 9 Acute Critical Care Department, Changhua Hospital, Ministry of Health and Welfare, Taiwan; Institute of Medicine, Chung Shan Medical University, Taiwan
  • 10 Department of Child Health, Faculty of Medicine, University of Indonesia/Ciptomangunkusumo Hospital, Jakarta, Indonesia
  • 11 National Lung Hospital, Hanoi, Viet Nam
  • 12 Department of Medicine and Therapeutics, Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
  • 13 National Center for Tuberculosis and Leprosy Control, Phnom Penh, Cambodia
Int J Infect Dis, 2019 Oct;87:21-29.
PMID: 31301458 DOI: 10.1016/j.ijid.2019.07.004

Abstract

Asia has the highest burden of tuberculosis (TB) and latent TB infection (LTBI) in the world. Optimizing the diagnosis and treatment of LTBI is one of the key strategies for achieving the WHO 'End TB' targets. We report the discussions from the Asia Latent TubERculosis (ALTER) expert panel meeting held in 2018 in Singapore. In this meeting, a group of 13 TB experts from Bangladesh, Cambodia, Hong Kong, India, Indonesia, Malaysia, Myanmar, the Philippines, Singapore, Taiwan, Thailand and Vietnam convened to review the literature, discuss the barriers and propose strategies to improve the management of LTBI in Asia. Strategies for the optimization of risk group prioritization, diagnosis, treatment, and research of LTBI are reported. The perspectives presented herein, may help national programs and professional societies of the respective countries enhance the adoption of the WHO guidelines, scale-up the implementation of national guidelines based on the regional needs, and provide optimal guidance to clinicians for the programmatic management of LTBI.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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