Affiliations 

  • 1 School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University Lakeside Campus, 47500 Subang Jaya, Selangor, Malaysia. amjadayadqatranalkhdhairawi@sd.taylors.edu.my and Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA (UiTM) Selangor Branch, 42300 Bandar Puncak Alam, Selangor, Malaysia
  • 2 Natural Products Inc., Evanston, IL, USA 60203 and Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA 32601
  • 3 Methodist College Kuala Lumpur, Brickfields, 50470 Kuala Lumpur, Malaysia
  • 4 School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University Lakeside Campus, 47500 Subang Jaya, Selangor, Malaysia. amjadayadqatranalkhdhairawi@sd.taylors.edu.my
  • 5 Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA (UiTM) Selangor Branch, 42300 Bandar Puncak Alam, Selangor, Malaysia
Org Biomol Chem, 2019 10 28;17(40):8943-8957.
PMID: 31482157 DOI: 10.1039/c9ob01501a

Abstract

Diterpene pyrones (DTPs) are a group of well-known, mainly fungal, natural products, first isolated in 1966. As the name indicates, they are composed of two main structural features: a diterpenyl moiety and a pyrone ring. Various names have been given to this class of metabolites; however, biogenetic evidence indicates that they originate through the same metabolic pathway. Based on their biosynthesis, which leads to differences in their structural architecture, the DTPs can be classified into three main types. In addition to their intriguing chemistry, these compounds demonstrate a wide range of biological activities rendering them a desirable target for total synthesis. To date, sixty-seven DTPs have been isolated from various fungal species, with one example originating from the plant kingdom. This review aims at unifying the classification of these compounds, in addition to presenting a detailed description of their isolation, bioactivities, biosynthesis, and total synthesis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.