• 1 Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), Tanjong Malim, Malaysia
  • 2 School of Environmental and Natural Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Malaysia
  • 3 School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Nat Prod Res, 2021 Jul;35(13):2279-2284.
PMID: 31544509 DOI: 10.1080/14786419.2019.1669027


The chemical composition of the essential oil of Knema kunstleri Warb. (Myristicaceae) was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). In total, 36 components were identified in the essential oil, which made up 91.7% of the total oil. The essential oil is composed mainly of β-caryophyllene (23.2%), bicyclogermacrene (9.6%), δ-cadinene (7.3%), α-humulene (5.7%), and germacrene D (4.3%). The essential oil showed moderate activity towards DPPH free-radical scavenging and lipoxygenase inhibition. To the best of our knowledge, this is the first study of the composition and bioactivities of the essential oil report concerning the genus Knema.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.