Be cautious applying carbon-fluorine bonds in drug delivery

Sonne C 1 , Lam SS 2 , Kim KH 3 , Rinklebe J 4 , Ok YS 5

Affiliations 

  • 1 Aarhus University, Roskilde, Denmark; Henan Agricultural University, China. Electronic address: cs@bios.au.dk
  • 2 Universiti Malaysia Terengganu, Malaysia; Henan Agricultural University, China
  • 3 Hanyang University, Seoul, Republic of Korea; Henan Agricultural University, China
  • 4 University of Wuppertal, Wuppertal, Germany; Sejong University, Department of Environment, Energy and Geoinformatics, Seoul 05006, Republic of Korea
  • 5 Henan Agricultural University, China; Korea University, Seoul, Republic of Korea
Chemosphere, 2020 Jun;248:125971.
PMID: 32035380 DOI: 10.1016/j.chemosphere.2020.125971

Abstract

As reported in Chemosphere by Colles et al. (2020), there are multiple pathways for human exposure to poly- and perfluoroalkyl substances (PFAS). Now, a new chemical formation of C-F bonds in drug delivery lead to concerns for human exposure as these inert chemical formations are resistance to metabolic degradation and excretion.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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