Displaying publications 1 - 20 of 175 in total

  1. Ma NL, Rahmat Z, Lam SS
    Int J Mol Sci, 2013;14(4):7515-41.
    PMID: 23567269 DOI: 10.3390/ijms14047515
    Physiological and ecological constraints that cause the slow growth and depleted production of crops have raised a major concern in the agriculture industry as they represent a possible threat of short food supply in the future. The key feature that regulates the stress signaling pathway is always related to the reactive oxygen species (ROS). The accumulation of ROS in plant cells would leave traces of biomarkers at the genome, proteome, and metabolome levels, which could be identified with the recent technological breakthrough coupled with improved performance of bioinformatics. This review highlights the recent breakthrough in molecular strategies (comprising transcriptomics, proteomics, and metabolomics) in identifying oxidative stress biomarkers and the arising opportunities and obstacles observed in research on biomarkers in rice. The major issue in incorporating bioinformatics to validate the biomarkers from different omic platforms for the use of rice-breeding programs is also discussed. The development of powerful techniques for identification of oxidative stress-related biomarkers and the integration of data from different disciplines shed light on the oxidative response pathways in plants.
  2. Xia C, Lam SS, Sonne C
    Science, 2021 03 19;371(6535):1214.
    PMID: 33737479 DOI: 10.1126/science.abh3100
  3. Xia C, Lam SS, Sonne C
    Science, 2020 Oct 30;370(6516):539.
    PMID: 33122375 DOI: 10.1126/science.abf0461
  4. Jayawardhana Y, Keerthanan S, Lam SS, Vithanage M
    Environ Res, 2021 06;197:111102.
    PMID: 33798520 DOI: 10.1016/j.envres.2021.111102
    The present study investigated adsorptive removal of toluene and ethylbenzene from the aqueous media via using biochar derived from municipal solid waste (termed "MSW-BC") in a single and binary contaminant system at 25-45 °C. The adsorption was evaluated at different pH (3-10), experimental time (up to 24 h), and initial adsorbate concentrations (10-600 μg/L) in single and binary contaminant system. A fixed-bed column experiment was also conducted using MSW-BC (0.25%) and influent concentration of toluene and ethylbenzene (4 mg/L) at 2 mL/min of flow rate. The adsorption of toluene and ethylbenzene on the MSW-BC was mildly dependent on the pH, and the peak adsorption ability (44-47 μg/g) was recorded at a baseline pH of ~8 in mono and dual contaminant system. Langmuir and Hill are the models that match the isotherm results in a single contaminant environment for both toluene (R2 of 0.97 and 0.99, respectively) and ethylbenzene (R2 of 0.99 and 0.99, respectively) adsorption. In the binary system, the isotherm models matched in the order of Langmuir > Hill > Freundlich for toluene, whereas Hill > Freundlich > Langmuir for ethylbenzene. The adsorption in the batch experiment was likely to take place via cooperative and multilayer adsorption onto MSW-BC involving hydrophobic, π- π and n- π attractions, specific interaction such as hydrogen-π and cation-π interactions, and van der Waals interactions. The thermodynamic results indicate exothermic adsorption occurred by physical attractions between toluene and ethylbenzene, and MSW-BC. The breakthrough behavior of toluene and ethylbenzene was successfully described with Yoon-Nelson and Thomas models. The data demonstrate that the low-cost adsorbent derived from the municipal solid waste can be utilized to remove toluene and ethylbenzene in landfill leachate.
  5. Peng W, Lam SS, Sonne C
    Science, 2020 01 17;367(6475):257-258.
    PMID: 31949072 DOI: 10.1126/science.aba5642
  6. Bilal M, Lam SS, Iqbal HMN
    Environ Pollut, 2022 Jan 15;293:118582.
    PMID: 34856243 DOI: 10.1016/j.envpol.2021.118582
    The discharge of an alarming number of recalcitrant pollutants from various industrial activities presents a serious threat to environmental sustainability and ecological integrity. Bioremediation has gained immense interest around the world due to its environmentally friendly and cost-effective nature. In contrast to physical and chemical methods, the use of microbial enzymes, particularly immobilized biocatalysts, has been demonstrated as a versatile approach for the sustainable mitigation of environmental pollution. Considerable attention is now devoted to developing novel enzyme engineering approaches and state-of-the-art bioreactor design for ameliorating the overall bio-catalysis and biodegradation performance of enzymes. This review discusses the contemporary and state of the art technical and scientific progress regarding applying oxidoreductase enzyme-based biocatalytic systems to remediate a vast number of pharmaceutically active compounds from water and wastewater bodies. A comprehensive insight into enzyme immobilization, the role of mediators, bioreactors designing, and transformation products of pharmaceuticals and their associated toxicity is provided. Additional studies are necessary to elucidate enzymatic degradation mechanisms, monitor the toxicity levels of the resulting degraded metabolites and optimize the entire bio-treatment strategy for technical and economical affordability.
  7. Sonne C, Lam SS, Kanstrup N
    Eco Environ Health, 2023 Mar;2(1):16-17.
    PMID: 38074451 DOI: 10.1016/j.eehl.2023.02.001
    Image 1.
  8. Lananan F, Jusoh A, Ali N, Lam SS, Endut A
    Bioresour Technol, 2013 Aug;141:75-82.
    PMID: 23562179 DOI: 10.1016/j.biortech.2013.03.006
    A study was performed to determine the effect of Conway and f/2 media on the growth of microalgae genera. Genera of Chlorella sp., Dunaliella sp., Isochrysis sp., Chaetoceros sp., Pavlova sp. and Tetraselmis sp. were isolated from the South China Sea. During the cultivation period, the density of cells were determined using Syringe Liquid Sampler Particle Measuring System (SLS-PMS) that also generated the population distribution curve based on the size of the cells. The population of the microalgae genera is thought to consist of mother and daughter generations since these microalgae genera reproduce by releasing small non-motile reproductive cells (autospores). It was found that the reproduction of Tetraselmis sp., Dunaliella sp. and Pavlova sp. could be sustained longer in f/2 Medium. Higher cell density was achieved by genus Dunaliella, Chlorella and Isochrysis in Conway Medium. Different genera of microalgae had a preference for different types of cultivation media.
  9. Sonne C, Peng WX, Alstrup AKO, Lam SS
    Science, 2021 Jun 18;372(6548):1271.
    PMID: 34140374 DOI: 10.1126/science.abj3359
  10. Lam SS, Waugh C, Peng W, Sonne C
    Science, 2020 02 14;367(6479):750.
    PMID: 32054755 DOI: 10.1126/science.aba8372
  11. Lam SS, Ma NL, Peng W, Sonne C
    Science, 2020 May 29;368(6494):958.
    PMID: 32467384 DOI: 10.1126/science.abc2202
  12. Xia C, Lam SS, Zhong H, Fabbri E, Sonne C
    Science, 2022 Nov 25;378(6622):842.
    PMID: 36423283 DOI: 10.1126/science.ade9069
  13. Li X, Lam SS, Xia C, Zhong H, Sonne C
    Science, 2023 Dec;382(6674):1007.
    PMID: 38033061 DOI: 10.1126/science.adl6721
  14. Xia C, Cai L, Lam SS, Sonne C
    Eco Environ Health, 2023 Jun;2(2):41-42.
    PMID: 38075294 DOI: 10.1016/j.eehl.2023.04.001
    •Microplastic pollution threats environmental and human health.•The resolution of End Plastic Pollution promotes the global strategy against plastic pollution.•The governments should launch relevant policies to implement this resolution.
  15. Ma NL, Teh KY, Lam SS, Kaben AM, Cha TS
    Bioresour Technol, 2015 Aug;190:536-42.
    PMID: 25812996 DOI: 10.1016/j.biortech.2015.03.036
    This study demonstrates the use of NMR techniques coupled with chemometric analysis as a high throughput data mining method to identify and examine the efficiency of different disruption techniques tested on microalgae (Chlorella variabilis, Scenedesmus regularis and Ankistrodesmus gracilis). The yield and chemical diversity from the disruptions together with the effects of pre-oven and pre-freeze drying prior to disruption techniques were discussed. HCl extraction showed the highest recovery of oil compounds from the disrupted microalgae (up to 90%). In contrast, NMR analysis showed the highest intensity of bioactive metabolites obtained for homogenized extracts pre-treated with freeze-drying, indicating that homogenizing is a more favorable approach to recover bioactive substances from the disrupted microalgae. The results show the potential of NMR as a useful metabolic fingerprinting tool for assessing compound diversity in complex microalgae extracts.
  16. Nasir NM, Bakar NS, Lananan F, Abdul Hamid SH, Lam SS, Jusoh A
    Bioresour Technol, 2015 Aug;190:492-8.
    PMID: 25791330 DOI: 10.1016/j.biortech.2015.03.023
    This study focuses on the evaluation of the performance of Chlorella sp. in removing nutrient in aquaculture wastewater and its correlation with the kinetic growth of Chlorella sp. The treatment was applied with various Chlorella sp. inoculation dosage ranging from 0% to 60% (v/v) of wastewater. The optimum inoculation dosage was recorded at 30% (v/v) with effluent concentration of ammonia and orthophosphate recording at 0.012mgL(-1) and 0.647mgL(-1), respectively on Day 11. The optimum dosage for bio-flocculation process was obtained at 30mgL(-1) of Aspergillus niger with a harvesting efficiency of 97%. This type of development of phytoremediation with continuous bio-harvesting could promote the use of sustainable green technology for effective wastewater treatment.
  17. Khounani Z, Hosseinzadeh-Bandbafha H, Nazemi F, Shaeifi M, Karimi K, Tabatabaei M, et al.
    J Environ Manage, 2021 Feb 01;279:111822.
    PMID: 33348185 DOI: 10.1016/j.jenvman.2020.111822
    The huge amount of agro-wastes generated due to expanding agricultural activities can potentially cause serious environmental and human health problems. Using the biorefinery concept, all parts of agricultural plants can be converted into multiple value-added bioproducts while reducing waste generation. This approach can be viewed as an effective strategy in developing and realizing a circular bioeconomy by accomplishing the dual goals of waste mitigation and energy recovery. However, the sustainability issue of biorefineries should still be thoroughly scrutinized using comprehensive resource accounting methods such as exergy-based approaches. In light of that, this study aims to conduct a detailed exergy analysis of whole-crop safflower biorefinery consisting of six units, i.e., straw handling, biomass pretreatment, bioethanol production, wastewater treatment, oil extraction, and biodiesel production. The analysis is carried out to find the major exergy sink in the developed biorefinery and discover the bottlenecks for further performance improvements. Overall, the wastewater treatment unit exhibits to be the major exergy sink, amounting to over 70% of the total thermodynamic irreversibility of the process. The biomass pretreatment and bioethanol production units account for 12.4 and 10.3% of the total thermodynamic inefficiencies of the process, respectively. The exergy rates associated with bioethanol, biodiesel, lignin, biogas, liquid digestate, seed cake, sodium sulfate, and glycerol are determined to be 5918.5, 16516.8, 10778.9, 1741.4, 6271.5, 15755.8, 3.4, and 823.5 kW, respectively. The overall exergetic efficiency of the system stands at 72.7%, demonstrating the adequacy of the developed biorefinery from the thermodynamic perspective.
  18. Mohd Nasir N, Mohd Yunos FH, Wan Jusoh HH, Mohammad A, Lam SS, Jusoh A
    J Environ Manage, 2019 Nov 01;249:109373.
    PMID: 31415924 DOI: 10.1016/j.jenvman.2019.109373
    Microalgae have been increasingly used to generate biofuel, thus a sustainable technique should be implemented to harvest the biomass to ensure its existence in the environment. Aspergillus niger was used as bio-flocculant to harvest microalgae from aquaculture wastewater via flocculation technique over a range of pH and mixing rate. The bio-flocculant showed ability to adapt at a wide range of pH from 3.0 to 9.0 and at a mixing rate of 100-150 rpm, producing a harvesting efficiency of higher than 90%. The treated water possessed low concentration of chlorophyll-a (0.3-0.6 mg L-1) and cell density (2 × 106-3 × 106 cell mL-1). These indicate that Aspergillus niger is a promising bio-flocculant to be used in harvesting microalgae, thus promoting the use of flocculation as a green technology in aquaculture wastewater treatment.
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