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Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes

Khan H 1 , Daraz N 1 , Khan MN 2 , Said M 3 , Akhtar N 1 , Badshah A 4 Show all authors , Khan AS 5 , Ali M 2

Affiliations 

  • 1 Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan
  • 2 Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan
  • 3 Department of Chemistry, Abdul Wali Khan University, Mardan 23200, Pakistan
  • 4 Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
  • 5 Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan ; PETRONAS Ionic Liquid Centre, Department of Chemical Engineering, Universiti Teknologi Petronas, Seri Iskandar, 31750 Tronoh, Perak, Malaysia
Bioinorg Chem Appl, 2014;2014:916361.
PMID: 25276113 DOI: 10.1155/2014/916361

Abstract

Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. They all have been synthesized and characterized by various spectroscopic techniques (elemental analysis, FTIR, and (1)H NMR and the ligand 1,3-bis(2-methoxyphenyl) thiourea was synthesized by single crystal X-ray diffraction technique). The synthesized compounds were screened for their antibacterial activity against four strains of bacteria (Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus subtilis). The antitumor potential was evaluated in terms of activity against brine shrimp eggs and DNA interaction. The mixed ligand complexes have exhibited moderate antibacterial activity and promising antitumor potential.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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