• 1 Department of Chemistry, Islamia College University, Peshawar, KPK 25120, Pakistan
  • 2 Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan
  • 3 Department of Chemistry, Sarhad University of Science & Information Technology, Peshawar 25000, Pakistan
  • 4 Faculty of Sciences, Department of Chemistry, University of Kotli, Kotli 11100, Azad Jammu and Kashmir, Pakistan
  • 5 Kosk Vocational School of Food Technology, Aydin Adnan Menderes University, Efeler 09010 Aydin, Turkey
  • 6 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
ACS Omega, 2019 Sep 03;4(10):14188-14192.
PMID: 31508540 DOI: 10.1021/acsomega.9b01041


The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). The in vivo antipyretic experiments showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals when injected with viscosine. Comparison of docking analyses with target enzymes showed strongest bonding interactions (binding energy -17.34 kcal/mol) of viscosine with the active-site pocket of mPGES-1. These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E2 in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.