Displaying publications 1 - 20 of 1467 in total

  1. Wong YP, Tan GC
    Malays J Pathol, 2021 Apr;43(1):1.
    PMID: 33903298
    No abstract available.
    Matched MeSH terms: Brain
  2. Chua TH, Takano A
    Malays J Pathol, 2021 04;43(1):121-125.
    PMID: 33903314
    No abstract available.
    Matched MeSH terms: Brain
  3. Albart SA, Yusof Khan AHK, Wan Zaidi WA, Muthuppalaniappan AM, Kandavello G, Koh GT, et al.
    Med J Malaysia, 2023 May;78(3):389-403.
    PMID: 37271850
    INTRODUCTION: About 20 to 40% of ischaemic stroke causes are cryptogenic. Embolic stroke of undetermined source (ESUS) is a subtype of cryptogenic stroke which is diagnosed based on specific criteria. Even though patent foramen ovale (PFO) is linked with the risk of stroke, it is found in about 25% of the general population, so it might be an innocent bystander. The best way to treat ESUS patients with PFO is still up for discussion.

    MATERIALS AND METHODS: Therefore, based on current evidence and expert opinion, Malaysian expert panels from various disciplines have gathered to discuss the management of ESUS patients with PFO. This consensus sought to educate Malaysian healthcare professionals to diagnose and manage PFO in ESUS patients based on local resources and facilities.

    RESULTS: Based on consensus, the Malaysian expert recommended PFO closure for embolic stroke patients who were younger than 60, had high RoPE scores and did not require long-term anticoagulation. However, the decision should be made after other mechanisms of stroke have been ruled out via thorough investigation and multidisciplinary evaluation. The PFO screening should be made using readily available imaging modalities, ideally contrasttransthoracic echocardiogram (c-TTE) or contrasttranscranial Doppler (c-TCD). The contrast-transesophageal echocardiogram (c-TEE) should be used for the confirmation of PFO diagnosis. The experts advised closing PFO as early as possible because there is limited evidence for late closure. For the post-closure follow-up management, dual antiplatelet therapy (DAPT) for one to three months, followed by single antiplatelet therapy (APT) for six months, is advised. Nonetheless, with joint care from a cardiologist and a neurologist, the multidisciplinary team will decide on the continuation of therapy.

    Matched MeSH terms: Brain Ischemia*
  4. Liew Y, Retinasamy T, Arulsamy A, Ali I, Jones NC, O'Brien TJ, et al.
    J Alzheimers Dis, 2023;94(s1):S253-S265.
    PMID: 37092226 DOI: 10.3233/JAD-230059
    BACKGROUND: Neuroinflammation is an innate immunological response of the central nervous system that may be induced by a brain insult and chronic neurodegenerative conditions. Recent research has shown that neuroinflammation may contribute to the initiation of Alzheimer's disease (AD) pathogenesis and associated epileptogenesis.

    OBJECTIVE: This systematic review aimed to investigate the available literature on the shared molecular mechanisms of neuroinflammation in AD and epilepsy.

    METHODS: The search included in this systematic review was obtained from 5 established databases. A total of 2,760 articles were screened according to inclusion criteria. Articles related to the modulation of the inflammatory biomarkers commonly associated with the progression of AD and epilepsy in all populations were included in this review.

    RESULTS: Only 7 articles met these criteria and were chosen for further analysis. Selected studies include both in vitro and in vivo research conducted on rodents. Several neuroinflammatory biomarkers were reported to be involved in the cross-talk between AD and epilepsy.

    CONCLUSION: Neuroinflammation was directly associated with the advancement of AD and epilepsy in populations compared to those with either AD or epilepsy. However, more studies focusing on common inflammatory biomarkers are required to develop standardized monitoring guidelines to prevent the manifestation of epilepsy and delay the progression of AD in patients.

    Matched MeSH terms: Brain/pathology
  5. Arumugasamy N
    Med J Malaya, 1966 Dec;21(2):149-60.
    PMID: 4227386
    Matched MeSH terms: Brain Diseases/pathology*; Brain Neoplasms/pathology*
  6. Ahmad Helmy AK, Salmah Jalaluddin WM, Ab Rahman IG
    Malays J Med Sci, 2010 Oct;17(4):51-6.
    PMID: 22135561 MyJurnal
    Brain ischaemia and infarction are the leading factors in morbidity and mortality of traumatic brain injury. This study aimed to determine the perfusion status of pericontusional hypodense areas in traumatic cerebral contusion
    Matched MeSH terms: Brain Ischemia; Brain Contusion; Brain Injuries, Traumatic
  7. Md S, Mustafa G, Baboota S, Ali J
    Drug Dev Ind Pharm, 2015;41(12):1922-34.
    PMID: 26057769 DOI: 10.3109/03639045.2015.1052081
    Brain disorders remain the world's leading cause of disability, and account for more hospitalizations and prolonged care than almost all other diseases combined. The majority of drugs, proteins and peptides do not readily permeate into brain due to the presence of the blood-brain barrier (BBB), thus impeding treatment of these conditions.
    Matched MeSH terms: Blood-Brain Barrier; Brain; Brain Diseases
  8. Abdullah S, Tan CT
    Handb Clin Neurol, 2014;123:663-70.
    PMID: 25015510 DOI: 10.1016/B978-0-444-53488-0.00032-8
    Matched MeSH terms: Brain/pathology; Brain/virology
  9. Siddiqui R, Yee Ong TY, Maciver S, Khan NA
    Ther Deliv, 2023 Aug;14(8):485-490.
    PMID: 37691579 DOI: 10.4155/tde-2023-0032
    Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site.
    Matched MeSH terms: Blood-Brain Barrier*; Brain
  10. Abdullah JM
    Med J Malaysia, 2011 Jun;66(2):83.
    PMID: 22106681
    Matched MeSH terms: Brain Injuries/diagnosis; Brain Injuries/etiology; Brain Injuries/therapy*
  11. Mokhtarudin MJ, Payne SJ
    PMID: 26991256 DOI: 10.1002/cnm.2784
    Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The cerebral space is assumed to be made of four fluid compartments: astrocyte, neuron, ECS and blood microvessels, and a solid matrix for the tissue, and this is modelled using multiple-network poroelastic theory. AQP4 allows the movement of water between astrocyte and the ECS and the microvessels. It is found that the presence of AQP4 may help in reducing vasogenic oedema shown by a decrease in brain tissue extracellular pressure. However, the astrocyte pressure will increase to compensate for this decrease, which may lead to cytotoxic oedema. In addition, the swelling will also depend on the ionic concentrations in the astrocyte and extracellular space, which may change after ischaemic stroke. Understanding the role of AQP4 in oedema may thus help the development of a treatment plan in reducing brain swelling after ischaemia-reperfusion.
    Matched MeSH terms: Brain/metabolism; Brain/pathology; Brain Edema/metabolism*; Brain Edema/pathology; Brain Ischemia/metabolism*; Brain Ischemia/pathology
  12. Mohamed Ludin S, Abdul Rashid N
    Clin Nurs Res, 2020 09;29(7):433-439.
    PMID: 30079766 DOI: 10.1177/1054773818792459
    Throughout recovery, patients with severe traumatic brain injury (TBI) show physical and functional improvement, but continue to have cognitive and psychosocial problems. The aim of this article was to review the literature regarding the functional and health-related quality of life (HRQOL) outcomes in severe TBI. There were 15 articles reviewed, 13 of them were quantitative studies and two were narrative review. Most of the articles showed an improvement occurs rapidly at 6 months post-injury. There were several factors that influence the outcome after TBI, most of it was the Glasgow Coma Scale (GCS) on admission, age, educational level, duration of posttraumatic amnesia (PTA), and length of stay (LOS) in the Intensive Care Unit (ICU). Thus, health care workers should help the survivors of severe TBI in the recovery process to ensure the latter can attain maximum function and quality of life.
    Matched MeSH terms: Brain Injuries*; Brain Injuries, Traumatic*
  13. Cheng KS, Lee JX, Lee PF
    Int J Occup Saf Ergon, 2021 Mar;27(1):258-266.
    PMID: 29658406 DOI: 10.1080/10803548.2018.1459348
    Purpose. Work performance is closely related to one's attention level. In this study, a brain-computer interface (BCI) device suitable for office usage was chosen to quantify the individual's attention levels. Methods. A BCI system was adopted to interface brainwave signals to a coffee maker via three ascending levels of laser detectors. The preliminary test with this prototype was to characterize the attention level through the collected coffee amount. Here, the preliminary testing was comparing the correlation between the attention level and the participants' cumulative grade point average (CGPA) and scores from the 21-item depression, anxiety, and stress scale (DASS-21) and the attentional control scale (ACS) using ordinal regression. It was assumed that a greater CGPA would generate a greater attention level. Result. The generated coffee amount from the BCI system had a significant positive correlation with the CGPA (p = 0.004), mild depression (p = 0.019) and mild and extremely severe anxiety (p = 0.044 and p = 0.019, respectively) and a negative correlation with the ACS score (p = 0.042). Conclusion. This simple and cost-effective prototype has the potential to enable everyone to know their immediate attention level and predict the possible correlation to their mental state.
    Matched MeSH terms: Brain Waves*; Brain-Computer Interfaces*
    Med J Malaya, 1962 Mar;16:193-205.
    PMID: 14465296
    Matched MeSH terms: Brain*; Brain Diseases*
  15. Ong LK
    Int J Mol Sci, 2022 Dec 16;23(24).
    PMID: 36555665 DOI: 10.3390/ijms232416024
    Recently, a growing body of evidence has indicated that secondary neurodegeneration after stroke occurs at remote regions of the brain that are connected to the primary infarction site [...].
    Matched MeSH terms: Brain
  16. Veeramuthu V, Hariri F, Narayanan V, Tan LK, Ramli N, Ganesan D
    J Oral Maxillofac Surg, 2016 Jun;74(6):1197.e1-1197.e10.
    PMID: 26917201 DOI: 10.1016/j.joms.2016.01.042
    The aim of the present study was to establish the incidence of maxillofacial (MF) injury accompanying mild traumatic brain injury (mTBI) and the associated neurocognitive deficits and white matter changes.
    Matched MeSH terms: Brain Concussion; Brain Injuries
  17. Glasauer FE
    Surg Neurol, 1976 Oct;6(4):257-60.
    PMID: 968728
    Matched MeSH terms: Brain Neoplasms/epidemiology*
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