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Curcuma longa rhizome extract and Curcumin reduce the adhesion of Acanthamoeba triangularis trophozoites and cysts in polystyrene plastic surface and contact lens

Mitsuwan W 1 , Sangkanu S 2 , Romyasamit C 2 , Kaewjai C 3 , Jimoh TO 4 , de Lourdes Pereira M 5 Show all authors , Siyadatpanah A 6 , Kayesth S 7 , Nawaz M 8 , Rahmatullah M 9 , Butler MS 10 , Wilairatana P 11 , Wiart C 12 , Nissapatorn V 13

Affiliations 

  • 1 School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team), World Union for Herbal Drug Discovery (WUHeDD), and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat, Thailand; Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, Thailand
  • 2 School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team), World Union for Herbal Drug Discovery (WUHeDD), and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat, Thailand
  • 3 Faculty of Medical Technology, Rangsit University, Pathum Thani, Thailand
  • 4 Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok, Thailand; Department of Biochemistry, Habib Medical School, Islamic University in Uganda, Kampala, Uganda
  • 5 CICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, Aveiro, Portugal
  • 6 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, Iran
  • 7 Department of Zoology, Deshbandhu College, University of Delhi, Delhi, India
  • 8 Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • 9 Department of Biotechnology & Genetic Engineering, University of Development Alternative Lalmatia, Dhaka, Bangladesh
  • 10 Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
  • 11 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
  • 12 School of Pharmacy, University of Nottingham Malaysia Campus, Selangor, Malaysia
  • 13 School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team), World Union for Herbal Drug Discovery (WUHeDD), and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat, Thailand. Electronic address: nissapat@gmail.com
Int J Parasitol Drugs Drug Resist, 2020 12;14:218-229.
PMID: 33238231 DOI: 10.1016/j.ijpddr.2020.11.001

Abstract

Curcuma longa and Curcumin have been documented to have a wide spectrum of pharmacological effects, including anti-Acanthamoeba activity. Hence, this study sought to explore the anti-adhesion activity of C. longa extract and Curcumin against Acanthamoeba triangularis trophozoites and cysts in plastic and contact lenses. Our results showed that C. longa extract and Curcumin significantly inhibited the adhesion of A. triangularis trophozoites and cysts to the plastic surface, as investigated by the crystal violet assay (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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