Fulltext

Curcuma longa ethanol extract and Curcumin inhibit the growth of Acanthamoeba triangularis trophozoites and cysts isolated from water reservoirs at Walailak University, Thailand

Mitsuwan W 1 , Bunsuwansakul C 1 , Leonard TE 1 , Laohaprapanon S 2 , Hounkong K 3 , Bunluepuech K 4 Show all authors , Kaewjai C 5 , Mahboob T 6 , Sumudi Raju C 6 , Dhobi M 7 , Pereira ML 8 , Nawaz M 9 , Wiart C 10 , Siyadatpanah A 11 , Norouzi R 12 , Nissapatorn V 1

Affiliations 

  • 1 School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team) and World Union for Herbal Drug Discovery (WUHeDD), Walailak University , Nakhon Si Thammarat, Thailand
  • 2 School of Public Health, Walailak University , Nakorn Si Thammarat, Thailand
  • 3 Faculty of Medicine, Princess of Naradhiwas University , Narathiwat, Thailand
  • 4 School of Allied Health Sciences and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University , Nakhon Si Thammarat, Thailand
  • 5 Faculty of Medical Technology, Rangsit University , Pathum Thani, Thailand
  • 6 Department of Medical Microbiology, Faculty of Medicine, University of Malaya , Kuala Lumpur, Malaysia
  • 7 Department of Pharmacognosy and Phytochemistry, Delhi Pharmaceutical Sciences and Research University , Delhi, India
  • 8 Department of Medical Sciences and CICECO-Aveiro Institute of Materials, University of Aveiro , Aveiro, Portugal
  • 9 Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University , Dammam, Saudi Arabia
  • 10 School of Pharmacy, Nottingham University , Selangor, Malaysia
  • 11 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences , Birjand, Iran
  • 12 Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz , Tabriz, Iran
Pathog Glob Health, 2020 05 18;114(4):194-204.
PMID: 32315247 DOI: 10.1080/20477724.2020.1755551

Abstract

CURCUMA LONGA: (C. longa) rhizome extract has been traditionally used to treat many infections. Curcumin, a pure compound isolated from the plant, has been documented to possess a wide spectrum of pharmacological effects. The present study aimed to investigate the effects of Thai medicinal plant extracts including C. longa extract and Curcumin on Acanthamoeba triangularis, a causative agent of human Acanthamoeba keratitis. The parasite was isolated from the recreational reservoir at Walailak University, Thailand. The organism was identified as A. triangularis using morphology and 18S rDNA nucleotide sequences. The pathogen was tested for their susceptibility to ethanol extracts of Thai medicinal plants based on eye infection treatment. The ethanol C. longa extract showed the strongest anti-Acanthamoeba activity against both the trophozoites and cysts, followed by Coscinium fenestratum, Coccinia grandis, and Acmella oleracea extracts, respectively. After 24 h, 95% reduction of trophozoite viability was significantly decreased following the treatment with C. longa extract at 125 µg/mL, compared with the control (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications