Therapeutic promises of ginkgolide A: A literature-based review

Sarkar C 1 , Quispe C 2 , Jamaddar S 1 , Hossain R 1 , Ray P 1 , Mondal M 1 Show all authors , Abdulwanis Mohamed Z 3 , Sani Jaafaru M 4 , Salehi B 5 , Islam MT 6 , Faizal Abdull Razis A 7 , Martorell M 8 , Pastene-Navarrete E 9 , Sharifi-Rad J 10

Affiliations 

  • 1 Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh
  • 2 Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
  • 3 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address: zeinab9008@gmail.com
  • 4 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Biochemistry, Kaduna State University, Main Campus, PMB 2339, Kaduna, Nigeria. Electronic address: biojafar@gmail.com
  • 5 Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: bahar.salehi007@gmail.com
  • 6 Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address: muhammad.torequl.islam@tdtu.edu.vn
  • 7 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Laboratory of Food Safety and Food Integrity, Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. Electronic address: madfaizal@upm.edu.my
  • 8 Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción 4070386, Chile; Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción 4070386, Chile
  • 9 Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción 4070386, Chile; Departamento Laboratorio de Síntesis y Biotransformaciones, Departamento de Ciencias Básicas, Universidad del BioBio, Avenida Andrés Bello, 720, Chillán, Chile
  • 10 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: javad.sharifirad@gmail.com
Biomed Pharmacother, 2020 Dec;132:110908.
PMID: 33254431 DOI: 10.1016/j.biopha.2020.110908

Abstract

Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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