Affiliations 

  • 1 Laboratory of Peptide Research and Development, School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago, West Indies
  • 2 Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA
  • 3 Department of Pharmaceutical Chemistry, The Oxford College of Pharmacy, Bangalore, Karnataka, India
  • 4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Bedong, Kedah, Malaysia
  • 5 Department of Pharmacy Practice, Arya College of Pharmacy, Bareilly, Uttar Pradesh, India
  • 6 Department of Pharmaceutical Chemistry, Lakshmi Narain College of Pharmacy, Bhopal, Madhya Pradesh, India
Arch Pharm (Weinheim), 2021 Feb 01.
PMID: 33522644 DOI: 10.1002/ardp.202000446

Abstract

Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most significant biomolecules due to their widespread bioproperties. The estrogenic activity, immunosuppressive activity, cytotoxicity, vasorelaxant activity, and other properties possessed by cyclic peptides from seeds of plants make these congeners attractive leads for the drug discovery process. The current study covers the important structural features, structure-activity relationship, synthesis methods, and bioproperties of plant seeds-originated bioactive peptides from Vaccaria segetalis, Linum usitatissimum, and Goniothalamus leiocarpus, which may prove vital for the development of novel therapeutics based on a peptide skeleton.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.