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Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects

Dahiya R 1 , Dahiya S 2 , Fuloria NK 3 , Kumar S 4 , Mourya R 5 , Chennupati SV 6 Show all authors , Jankie S 1 , Gautam H 7 , Singh S 8 , Karan SK 9 , Maharaj S 1 , Fuloria S 3 , Shrivastava J 10 , Agarwal A 11 , Singh S 1 , Kishor A 12 , Jadon G 13 , Sharma A 14

Affiliations 

  • 1 School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago
  • 2 Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA
  • 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Semeling, Bedong 08100, Kedah, Malaysia
  • 4 Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India
  • 5 School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar 6200, Ethiopia
  • 6 Department of Pharmacy, College of Medical and Health Sciences, Wollega University, P.O. Box 395, Nekemte, Ethiopia
  • 7 Arya College of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, Nawabganj, Bareilly 243407, Uttar Pardesh, India
  • 8 Department of Pharmaceutical Chemistry, Ideal Institute of Pharmacy, Wada, Palghar 421303, Maharashtra, India
  • 9 Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, Orissa, India
  • 10 Department of Pharmaceutical Chemistry, The Oxford College of Pharmacy, Hongasandra, Bangalore 560068, Karnataka, India
  • 11 Department of Pharmaceutical Chemistry, U.S. Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh 313603, Rajasthan, India
  • 12 Department of Pharmaceutical Biotechnology, Shrinathji Institute of Pharmacy, Nathdwara 313301, Rajsamand, Rajasthan, India
  • 13 Department of Pharmaceutical Chemistry, Shrinathji Institute of Pharmacy, Nathdwara 313301, Rajsamand, Rajasthan, India
  • 14 Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India
Mar Drugs, 2020 Jun 24;18(6).
PMID: 32599909 DOI: 10.3390/md18060329

Abstract

Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide-peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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