Affiliations 

  • 1 Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • 2 Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
  • 3 School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City, Vietnam
  • 4 Vingroup Big Data Institute, Hanoi, Vietnam
  • 5 Defence Services Medical Academy, Mingalardon, Myanmar
  • 6 Defence Services Medical Research Centre, Nay Pyi Taw, Myanmar
  • 7 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 8 Department of Biomedical Sciences, University of Nottingham (Malaysia Campus), Selangor, Malaysia
  • 9 Department of Pharmacy, College of Pharmacy, University of the Philippines Manila, Manila, Philippines
  • 10 Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila, Manila, Philippines
  • 11 Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
  • 12 Department of Pathology and Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
  • 13 Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia
  • 14 Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta, Indonesia
  • 15 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia
  • 16 National Center for Laboratory and Epidemiology (NCLE), Vientiane, Lao PDR
  • 17 Lao Tropical and Public Health Institute, Vientiane, Lao PDR
  • 18 University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualised Therapy, Patras, Greece
  • 19 The Golden Helix Foundation, London, UK
  • 20 Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 21 Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
  • 22 Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. mushiroda@riken.jp
  • 23 Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. wasun.cha@mahidol.ac.th
Hum Genome Var, 2021 Feb 04;8(1):7.
PMID: 33542200 DOI: 10.1038/s41439-021-00135-z

Abstract

Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.