• 1 School of Biological Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
  • 2 Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus, Kuala Terengganu, Terengganu, Malaysia
Crit Rev Biotechnol, 2021 Jun;41(4):474-490.
PMID: 33726581 DOI: 10.1080/07388551.2020.1869685


Polyhydroxyalkanoate (PHA) is a biogenic polymer that has the potential to substitute synthetic plastic in numerous applications. This is due to its unique attribute of being a biodegradable and biocompatible thermoplastic, achievable through microbial fermentation from a broad utilizable range of renewable resources. Among all the PHAs discovered, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] stands out as a next generation healthcare biomaterial for having high biopharmaceutical and medical value since it is highly compatible to mammalian tissue. This review provides a critical assessment and complete overview of the development and trend of P(3HB-co-4HB) research over the last few decades, highlighting aspects from the microbial strain discovery to metabolic engineering and bioprocess cultivation strategies. The article also outlines the relevance of P(3HB-co-4HB) as a material for high value-added products in numerous healthcare-related applications.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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