Affiliations 

  • 1 Development of Research & Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
  • 2 School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • 3 Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran
  • 4 Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • 5 Hematology-Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran
  • 6 Department of Nutrition and Dietetics Faculty of Medicine and Health Sciences , University Putra Malaysia , Selangor Serdang, Malaysia
  • 7 Centre of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark
  • 8 Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
  • 9 Social Determinants of Health Research Center Alborz, University of Medical Sciences , Karaj, Iran
  • 10 Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
J Diabetes Metab Disord, 2021 Jun;20(1):1051-1062.
PMID: 34222098 DOI: 10.1007/s40200-021-00821-3

Abstract

Purpose: Selenium (Se) is a trace element having significant effects on human metabolism. Recent studies suggest that Se supplementation have a pivotal effect on the inflammatory markers. Therefore, the aim of this study was to assess the effect of Se supplementation on plasma inflammatory markers including C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) and nitric oxide (NO) as a stress oxidative index, among patients with metabolic diseases.

Methods: To assess the effects of Se on the inflammatory markers, following the PRISMA-P guidelines, we systematically searched ISI/WOS, PubMed/MEDLINE, and Scopus for studies that assessed the effect of Se supplementation on the inflammatory markers. Data extraction was performed by two independent investigators. Using the random effects or fixed-effects model depending on the results of heterogeneity tests was used to estimate the pooled standardized mean difference (SMD). Heterogeneity between studies was assessed using Cochran's Q test and I2 index.

Results: The initial search revealed 3,320 papers. After screening process and considering inclusion criteria, 7 publications were eligible for inclusion in the meta-analysis. The meta-analysis results showed that Se supplementation did not significantly affect CRP and hs-CRP concentrations (mean difference (MD) = -0.15; 95% CI: -0.55- 0.23; P = 0.43). Subgroup analysis of CRP type showed that Se supplementation significantly decreased hs-CRP level (pooled SMD = -0.44; 95% CI: -0.67-0.21). Moreover, no significant change was observed in NO level by continuing to take Se supplementation, (pooled SMD: 0.003, 95%CI: -0.26, 0.26).

Conclusions: This study revealed that Se supplementation would have desirable effects on cardio-metabolic indicators through affecting the levels of inflammatory markers. Given the importance of concerns, more attention should be given to more prospective studies with longer follow-up.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.