Multidisciplinary biomarkers aggrieve morbidity in schistosomiasis

Noha MA 1 , Enas AE 2 , Aly E 3 , Mohamed AE 4

Affiliations 

  • 1 Medical Parasitology Department, College of Medicine, Cairo University, Cairo, Egypt
  • 2 Medical Parasitology Department, College of Medicine, Cairo University, Cairo, Egypt and Medical Parasitology Department, Armed Forces College of Medicine, Cairo, Egypt
  • 3 Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
  • 4 Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt
Trop Biomed, 2019 Dec 01;36(4):833-844.
PMID: 33597455

Abstract

BACKGROUND: Biomarkers by definition are measurable molecules that mark the evidence of certain pathological processes. Collaboration of various biomarkers influences morbidity of schsitosomiasis in Egypt.

OBJECTIVES: To identify the biomarkers: CRP, IgE, hemoglobin, ferritin, vitamin D, and platelets in terms of relationship with active and chronic schistosomiasis; demographic data, and their interinfluence.

STUDY DESIGN: A cross-sectional study.

METHODS: Parasitological analysis of stool and urine samples, Indirect Hemagglutination Test, Enzyme linked Immunoassay, Hematology Analyzer, and Statistical Package SPSS (Statistical Package for the Social Sciences) version 25.

RESULTS: Out of 400 participants, 25% suffered of schistosomiasis: active S. mansoni infections in 7 cases (1.75%), S. haematobium infections in 6 cases (1.5%), and chronic schistosomiasis infections in 20 cases (5%). Creactive protein (CRP) likewise IgE levels were higher in active S. mansoni and S. haematobium infections when compared with chronic schistosomiasis. IgE levels appeared to affect infection intensity in S. haematobium. Inversely, hemoglobin (Hb) values were low in active schistosomiasis and upgraded in chronic infection (*p<0.05). Ferritin levels varied in active Schistosoma infection and normalized during chronicity. Vitamin D was reduced in active and chronic schistosomiais. Platelet counts were within normal ranges throughout the study groups. Distribution of ferritin, vit D, and platelets was statistically insignificant among Schistosoma infected population. Age affected only hemoglobin, CRP, and IgE biomarkers. CRP and IgE were in direct relationship together and inversely proportional with hemoglobin (*P <0.05).

CONCLUSION: Anemia increased proportionally with biomarkers of inflammatory stress (CRP and IgE) in early infections. Meanwhile, Hb and ferritin (iron stores) improved during chronicity. Hypovitaminosis-D associated the entire course of schistosomiasis while platelet counts were not affected.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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