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Fulltext Perception towards health promotion activities: findings from a community survey in the state of Penang, Malaysia

Hassali, M.A., Saleem, F., Shafie, A.A., Aljadhey, H., Chua, G.N., Masood, I., et al.

Malaysian Journal of Public Health Medicine, 2012;12(2):6-14.

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The study aimed to explore the perceptions towards health promotion activities among population of Penang Island,
Malaysia. The study was designed as a questionnaire based cross sectional analysis. General public from the district of
Jelutong, located in the state of Penang, Malaysia was conveniently approached for the study. Descriptive statistics
were used to ascertain demographic characteristics where as inferential statistics were employed to measure the
extent of association among study variables. Out of 480 respondents, a response rate of 82.7% was achieved. The study
cohort was dominated by females (63.0%) and majority of the participants belonged to Malay ethnicity (88.1%). One
hundred and seventy two (43.3%) never attended a health promotional campaign and mentioned lack of time and
transport as potential barriers. Among those who attended such activities, one third was satisfied with the benefits of
health campaigns. Approximately 90% of the participants demanded accessible locations, common language as mode of
communication and complete medical checkups with professional advice at health promotional campaigns. General
public can encouraged to participate in the health promotion activities by considering their priorities before designing
a health promotion program. This will help in targeting and achieving the goal “health for all”.

Purpose, Belief And Rate of Disclosure of Cam Use Among Diabetic Patients In Quetta, Pakistan

Ul Haq N, Saeed S, Iqbal Q, Naseem A, Razaq G, Farooqui M

Value Health, 2015 Nov;18(7):A865-6.

PMID: 26534632 DOI: 10.1016/j.jval.2015.09.517

Use of complementary and alternative medicines (CAM) in diabetics patients In Quetta [Abstract]

Ul Haq N, Saeed S, Iqbal Q, Naseem A, Razaq G, Farooqui M

Value Health, 2015 Nov;18(7):A865.

PMID: 26534631 DOI: 10.1016/j.jval.2015.09.516

Objectives: The current study aimed to determine the prevalence of Complementary and Alternative Medicines (CAM) and its types used in diabetes patients in Quetta, Pakistan.
Methods: A cross-sectional study was undertaken with diabetes patients, attending different government and private hospitals and clinic of Quetta city, Pakistan. A self-administered questionnaire containing 16 questions (5 questions related with disease and remaining questions were for information regarding CAM use). Descriptive statistics were applied to evaluate the patient’s demographics. Inferential statistics were used to fine the association between demographics characteristics and CAM (p<0.05).
Results: A total of 500 questionnaires were distributed and 451 were returned (with response rate of 90.2%). Out of 451 patients 148 (32.8%) used CAM for the diabetes treatment, out of which 87 (58.8%) were females and 61 (41.2%) were males. Most of the participants were uneducated 51 (34.5%) and belongs to large families 89 (60.1%). Fifty (33.8%) participants were using mind body intervention, followed by alternative medical system (33.1%) and herbal products (31.8%) respectively for treatment of diabetes. Type of family, monthly income and per month medicine cost were significant associated (p<0.05) with CAM use.
Conclusions: The current study indicated that diabetes patients used mind body intervention, alternative medical system and herbal products are the most common CAM type used for diabetes control. Further research is recommended to evaluate the diabetes control in patients with CAM used.

Sci-Hub & ethical issues

Saleem F, Hasaali MA, Ul Haq N

Res Social Adm Pharm, 2016 09 14;13(1):253.

PMID: 27720437 DOI: 10.1016/j.sapharm.2016.09.001

Fulltext A qualitative exploration of Malaysian doctors' perceptions towards complementary and alternative medicines (CAM) [Abstract]

Farooqui M, Othman CN, Hassali AA, Saleem F, Ul Haq N, Sadeeqa S

Value Health, 2014 Nov;17(7):A789.

PMID: 27202944 DOI: 10.1016/j.jval.2014.08.425

Objectives: The study aims to assess doctors’ perceptions towards Complementary and Alternative Medicines (CAM) in their medical practice, factors that affect the referral of CAM and suggestions to improve CAM in medical practice.
Methods: A qualitative research approach was adopted to gain a better understanding of the current perceptions and practice held by doctors’ within their medical professions. In order to gain a wide perspective of the issue, eleven doctors were purposively selected who were working in academics, hospitals and in the community health clinics. Participants were interviewed using a semi-structured interview guide. A saturation point was reached after the 10th interview, and no new information emerged with the subsequent interviews. All interviews were transcribed verbatim and analyzed by means of a standard content analysis framework.
Results: The doctors expressed a range of views on CAM that can be divided into two major themes: doctors’ knowledge and understanding towards CAM and doctors’ viewpoint on CAM in their professional practice. A key factor which affected doctor’s perspectives on CAM was the lack of scientific evidences. The attitudes on CAM were basically shaped based on their personal CAM use rather than knowledge gained during an academic course. Lack of knowledge on CAM was also attributing to the doctors’ reluctance in CAM discussion with their patients. Though addition of CAM courses into the medical curriculum was proposed by some of the doctors; the practical implication was criticized as some found medical curriculum heavily packed with the biomedical courses.
Conclusions: Majority of the doctors in this study were skeptical and uncertain about CAM due to lack of scientific evidence. Doctor-patient communication on CAM can only be improved when doctors’ knowledge on CAM can be improved by providing necessary training on CAM.

Fulltext Effect of Health Education Program on Knowledge, Attitude, Practice and Health Related Quality of Life in Hepatitis-B Patients

Haq N, Hassali MA, Shafie AA, Saleem F, Farooqui M, Iqbal Q

Value Health, 2014 Nov;17(7):A807.

PMID: 27203043 DOI: 10.1016/j.jval.2014.08.529

Fulltext A cross-sectional assessment of knowledge, attitude and practice among Hepatitis-B patients in Quetta, Pakistan

ul Haq N, Hassali MA, Shafie AA, Saleem F, Farooqui M, Haseeb A, et al.

BMC Public Health, 2013;13:448.

PMID: 23641704 DOI: 10.1186/1471-2458-13-448

Hepatitis-B is a life threatening infection resulting in 0.6 million deaths annually. The prevalence of Hepatitis-B is rising in Pakistan and furthermore, there is paucity of information about Knowledge, Attitude and Practice among Hepatitis-B patients. Better disease related knowledge is important to have positive attitude and that will bring the good practices which will prevent the further spread of infection. This study aimed to evaluate knowledge, attitude and practice of Hepatitis-B Patients in Quetta city, Pakistan.

Pharmacist intervention in improving hypertension-related knowledge, treatment medication adherence and health-related quality of life: a non-clinical randomized controlled trial

Saleem F, Hassali MA, Shafie AA, Ul Haq N, Farooqui M, Aljadhay H, et al.

Health Expect, 2015 Oct;18(5):1270-81.

PMID: 23786500 DOI: 10.1111/hex.12101

The study evaluated whether a pharmaceutical care intervention can result in better understanding about hypertension, increase medication adherence to antihypertensive therapy and improve overall health-related quality of life.

Saleem F, Hassali MA, Shafie AA, Atif M, Ul Haq N, Aljadhey H

South Med Rev, 2012 Jul;5(1):47-52.

PMID: 23093899

This study aims to evaluate association between Health related quality of lifeand disease state knowledge among hypertensive population of Pakistan.

Fulltext A cross sectional assessment of health related quality of life among patients with Hepatitis-B in Pakistan

ul Haq N, Hassali MA, Shafie AA, Saleem F, Aljadhey H

Health Qual Life Outcomes, 2012 Aug 06;10:91.

PMID: 22866752 DOI: 10.1186/1477-7525-10-91

OBJECTIVE: The study aims to assess Health Related Quality of Life (HRQoL) among Hepatitis B (HB) patients and to identify significant predictors of the HRQoL in HB patients of Quetta, Pakistan.

METHODS: A cross sectional study by adopting European Quality of Life scale (EQ-5D) for the assessment of HRQoL was conducted. All registered HB patients attending two public hospitals in Quetta, Pakistan were approached for study. Descriptive statistics were used to describe demographic and disease related characteristics of the patients. HRQoL was scored using values adapted from the United Kingdom general population survey. EQ-5D scale scores were compared with Mann-Whitney and Kruskal-Wallis test. Standard multiple regression analysis was performed to identify predictors of HRQoL. All analyses were performed using SPSS v 16.0.

RESULTS: Three hundred and ninety HB patients were enrolled in the study. Majority of the participants (n = 126, 32.3%) were categorized in the age group of 18-27 years (36.07 ± 9.23). HRQoL was measured as poor in the current study patients (0.3498 ± 0.31785). The multivariate analysis revealed a significant model (F(10, 380) = 40.04, P

Fulltext Assessment of general public satisfaction with public healthcare services in Kedah, Malaysia

Hassali MA, Alrasheedy AA, Ab Razak BA, Al-Tamimi SK, Saleem F, Ul Haq N, et al.

Australas Med J, 2014;7(1):35-44.

PMID: 24567765 DOI: 10.4066/AMJ.2014.1936

Patient satisfaction is considered an essential component of healthcare services evaluation and an additional indicator of the quality of healthcare. Moreover, patient satisfaction may also predict health-related behaviours of patients such as adherence to treatment and recommendations.

Cross Sectional Assessment of Health Related Quality of Life (HRQoL) among patients with cancer in Malaysia

Farooqui M, Hassali MA, Knight A, Shafie AA, Farooqui MA, Saleem F, et al.

Asian Pac J Cancer Prev, 2013;14(5):3017-21.

PMID: 23803072

BACKGROUND: Health Related Quality of Life (HRQoL) is an important aspect in identifying cancer patients' perceptions of being diagnosed with cancer and the assessment of treatment outcomes. The present study aimedto assess the profile and predicators of HRQoL of Malaysian oncology patients.

MATERIALS AND METHODS: A cross sectional study adopting the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was conducted. All cancer patients attending Penang General Hospital between August-November 2011 were approached. Descriptive statistics were used to assess demographic and disease related characteristics of the patients. All analyses were performed using SPSS v 16.0.

RESULTS: Three hundred and ninety three cancer patients met the inclusion criteria and were enrolled in the study. The mean age was 53.9 (SD±13) years. The cohort was dominated by females (n=260, 66.2%). Nearly half (n=190, 48.3%) of the participants were of Malay ethnicity, practicing Islam as their religion (n=194, 49.4%). Two hundred and ninety six (n=296, 75.3%) had beene diagnosed with cancer within six months to 3 years previously. The most common primary cancer site was breast (n=143, 36.4%). The mean Global Health Status (GHS) score was 60.7 (SD=21.3). Females (mean GHS score of 62.3, p=0.035) with Malay ethnicity (mean GHS score of 63.8, p=0.047), practicing Islam as their religion (mean GHS score of 63.0, p=0.011) had better GHS scores. Patients having medical insurance had good scores (mean 65.6, p=0.021). Marital status was significantly associated with GHS scores (p=0.022). Bone cancer patientshad the lowest mean GHS score of 49.2 (p=0.044). Patients at very advanced stages of cancer featured a low GHS mean score of 52.2 (p<0.001).

CONCLUSIONS: The present study identified many demographic and disease related factors which may contribute to the HRQoL of cancer patients, pointing to the necessity for improved management of disease symptoms and provision of psychological and financial support.

Fulltext Salmonella-innovative targeting carrier: Loading with doxorubicin for cancer treatment

Rabea S, Alanazi FK, Ashour AE, Salem-Bekhit MM, Yassin AS, Moneib NA, et al.

Saudi Pharm J, 2020 Oct;28(10):1253-1262.

PMID: 33132719 DOI: 10.1016/j.jsps.2020.08.016

Cell- based targeted delivery is recently gain attention as a promising platform for delivery of anticancer drug in selective and efficient manner. As a new biotechnology platform, bacterial ghosts (BGs) have novel biomedical application as targeted drug delivery system (TDDS). In the current work, Salmonellas' BGs was utilized for the first time as hepatocellular cancer (HCC) in-vitro targeted delivery system. Successful BGs loading and accurate analysis of doxorubicin (DOX) were necessary steps for testing the applicability of DOX loaded BGs in targeting the liver cancer cells. Loading capacity was maximized to reach 27.5 µg/mg (27.5% encapsulation efficiency), by incubation of 10 mg BGs with 1 mg DOX at pH 9 in constant temperature (25 °C) for 10 min. In-vitro release study of DOX loaded BGs showed a sustained release (182 h) obeying Higuchi sustained kinetic release model. The death rate (tested by MTT assay) of HepG2 reached to 64.5% by using of 4 μg/ml, while it was about 51% using the same concentration of the free DOX (P value

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