MyMedR

Displaying all 5 publications

Abstract:

Sort:

Single-step green route synthesis of Au/Ag bimetallic nanoparticles using clove buds extract: Enhancement in antioxidant bio-efficacy and catalytic activity

Sharma C, Ansari S, Ansari MS, Satsangee SP, Srivastava MM

Mater Sci Eng C Mater Biol Appl, 2020 Nov;116:111153.
PMID: 32806256 DOI: 10.1016/j.msec.2020.111153

In present work, we demonstrate a single step environmentally benign approach to synthesize Au/Ag bimetallic nanoparticles (BMNPs) using aqueous extract of Clove buds for the first time. Clove bud's (CB) extract has proficiency to act as a reducing and stabilizing agent for the formation of Au/Ag BMNPs. In presence of extract, AuIII and AgI are reduced competitively within same solution and produce Au/Ag alloy NPs. The kinetics besides the formation of NPs was studied using UV-visible spectroscopy and efficiency of the extract was monitored by varying contact time, temperature, pH and extract concentration. The electron microscopic studies revealed the presence of NPs with peculiar morphology at alkaline pH. Further, the existence of Au and Ag atoms was investigated using energy dispersive X-ray (EDX), X-ray diffraction (XRD) and cyclic voltammetry (CV) techniques. Fourier transform infrared spectroscopy (FTIR) showed that Eugenol in the extract is mainly responsible for the production of NPs which are also surrounded by various phytochemicals. Zeta potential of all the NPs is found to be negative which prevents their agglomeration due to inter-repulsion and the biosynthesized Au/Ag BMNPs revealed greater catalytic efficiency for the degradation of methyl orange (MO), methylene blue (MB) and reduction of p-nitrophenol (p-NP). Significant enhancement induced by BMNPs compared to individual monometallic nanoparticles (MMNPs) was assigned to the synergistic effect of MMNPs and coating of phytochemicals present in the CB extract.
Fulltext The Role of Speckle-Tracking Echocardiography in Predicting Mortality and Morbidity in Patients With Congenital Heart Disease: A Systematic Review and Meta-analysis

Dorobantu DM, Amir NH, Wadey CA, Sharma C, Stuart AG, Williams CA, et al.

J Am Soc Echocardiogr, 2024 Feb;37(2):216-225.
PMID: 37972793 DOI: 10.1016/j.echo.2023.11.003

BACKGROUND: Speckle-tracking echocardiography (STE) is now routinely included in cardiac evaluations, but its role in predicting mortality and morbidity in congenital heart disease (CHD) is not well described. We conducted a systematic review to evaluate the prognostic value of STE in patients with CHD.
METHODS: The EMBASE, Medline, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched from inception to January 2023 for terms related to all CHD, STE, and prognosis. Meta-analysis of association of right ventricle and left ventricle strain (RV Sl and LV Sl, respectively) with major adverse cardiovascular events (MACEs) was performed in atrial switch transposition of the great arteries (asTGA)/congenitally corrected TGA (ccTGA), tetralogy of Fallot (ToF), and congenital aortic stenosis (cAS)/bicuspid aortic valve (BAV). P-value combination analysis was additionally performed for all CHD groups.
RESULTS: A total of 33 studies (30 cohorts, n = 8,619 patients, children, and adults) were included. Meta-analysis showed the following parameters as being associated with MACE: RV Sl in asTGA/ccTGA (hazard ratio [HR] = 1.1/%; CI, [1.03; 1.18]), RV Sl and LV Sl in ToF (HR = 1.14/%; CI, [1.03; 1.26] and HR = 1.14/%; CI, [1.08; 1.2], respectively), and LV Sl in cAS/BAV (HR = 1.19/%; CI, [1.15; 1.23]). The RV Sl and strain rate were associated with outcomes also in single ventricle/hypoplastic left heart syndrome (at all palliation stages except before Norwood stage 1) and LV Sl in Ebstein's anomaly.
CONCLUSIONS: This systematic review and meta-analysis showed that biventricular strain and strain rate were associated with outcomes in a variety of CHD, highlighting the need for updated recommendations on the use of STE in the current guidelines, specific to disease types.
Fulltext Relative Contribution of Trabecular and Cortical Bone to Primary Implant Stability: An In vitro Model Study

Bera T, Kukreja BJ, Sharma C, Gupta VV, Patel P, Singhal P, et al.

J Pharm Bioallied Sci, 2024 Dec;16(Suppl 4):S3427-S3429.
PMID: 39927043 DOI: 10.4103/jpbs.jpbs_899_24

BACKGROUND: Primary implant stability is a crucial factor for the successful osseointegration and long-term success of dental implants. The contribution of trabecular and cortical bone to primary implant stability is not well understood.
MATERIALS AND METHODS: An in vitro model using synthetic bone blocks mimicking trabecular and cortical bone was used to simulate implant placement. The study involved 40 implants, divided into four groups based on bone type and density: Group A (low-density trabecular bone), Group B (high-density trabecular bone), Group C (low-density cortical bone), and Group D (high-density cortical bone). Primary stability was assessed using insertion torque values and resonance frequency analysis (RFA). Insertion torque was measured using a digital torque meter, and RFA was measured using an Osstell ISQ device.
RESULTS: Group D (high-density cortical bone) exhibited the highest insertion torque values (mean: 45 Ncm) and Implant Stability Quotient (ISQ) values (mean: 75), indicating superior primary stability. Group C (low-density cortical bone) showed moderate stability, with mean insertion torque values of 30 Ncm and ISQ values of 60. Group B (high-density trabecular bone) had lower stability, with mean insertion torque values of 25 Ncm and ISQ values of 55. Group A (low-density trabecular bone) demonstrated the least stability, with mean insertion torque values of 15 Ncm and ISQ values of 45.
CONCLUSION: The study concludes that cortical bone, especially high-density cortical bone, significantly contributes to primary implant stability compared to trabecular bone. The findings suggest that bone quality should be a major consideration during implant placement to ensure optimal primary stability and long-term success.
Targeting the vivid facets of apolipoproteins as a cardiovascular risk factor in rheumatoid arthritis

Sharma A, Sharma C, Sharma L, Wal P, Mishra P, Sachdeva N, et al.

Can J Physiol Pharmacol, 2024 May 01;102(5):305-317.
PMID: 38334084 DOI: 10.1139/cjpp-2023-0259

Mostly, cardiovascular diseases are blamed for casualties in rheumatoid arthritis (RA) patients. Customarily, dyslipidemia is probably the most prevalent underlying cause of untimely demise in people suffering from RA as it hastens the expansion of atherosclerosis. The engagement of inflammatory cytokines like tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), etc., is crucial in the progression and proliferation of both RA and abnormal lipid parameters. Thus, lipid abnormalities should be monitored frequently in patients with both primary and advanced RA stages. An advanced lipid profile examination, i.e., direct role of apolipoproteins associated with various lipid molecules is a more dependable approach for better understanding of the disease and selecting suitable therapeutic targets. Therefore, studying their apolipoproteins is more relevant than assessing RA patients' altered lipid profile levels. Among the various apolipoprotein classes, Apo A1 and Apo B are primarily being focused. In addition, it also addresses how calculating Apo B:Apo A1 ratio can aid in analyzing the disease's risk. The marketed therapies available to control lipid abnormalities are associated with many other risk factors. Hence, directly targeting Apo A1 and Apo B would provide a better and safer option.
Climate change, health, and discrimination: action towards racial justice

Deivanayagam TA, Selvarajah S, Hickel J, Guinto RR, de Morais Sato P, Bonifacio J, et al.

Lancet, 2023 Jan 07;401(10370):5-7.
PMID: 36343651 DOI: 10.1016/S0140-6736(22)02182-1