Blood lead concentration and 6»aminolevulinic acid in urine were used as indicator for lead exposure among school children in an industrial area south of the peninsular Malaysia. A group of 1 00 Malay children which consist of 48 boys and 52 girb with the age range of 61/2 to 81/2 years from a primary school were selected as chiMren. Blood samples were collected and analyzed with Graphite Furnace Atomic Absorption Spectrophotometer. The urine 6-aminolevulinic acid concentrations were measured with UV/VIS Spectrophotometer. The mean blood lead was 3.75ug/dl. Based on the biological index, 76% of the children are in the “normal range" (
The objective of this study was t0 determine the relationship between scores on McCarthy Scales of Children's Abilities (MSCA) and academic peU’ormance of school children. A total ofI12first and second graders aged 6 to 8 I/2 years old hom two primary schools in Kuala Lumpur, Malaysia were selected as subjects for this study. This selection was based on a random sampling stratyied proportionalhr according to school and sex. The MSCA was administered to 59 male and 53 female students. The test battery was translated from English to Malay and adapted to suit the local situation. Academic performance was measured using the mean percent of the total score on all the subjects (English, Malay, Mathematics and Islamic Religion) in the jinal examinations at the end of the year. T—test results indicated no signdicant dfference between MSCA scores and academic scores of maleandkmale students. The results revealed that all the scores on the MSCA and the General Cognitive Index were signyicantbr correlated with academic pejormance, The General Cognitive Index accounted for [0.4% ofthe variation in academic performance. T he findings appear to support that intelligence scores may be used to predict children 's academic performance in the early years of primary education.
Satu kajian keratan rentas telah daalanlcan ke atas kanak-lcanak yang tinggal 0.5 km dari sebuah lcuari di Sungai Siput Utara. Objelctif kajian ini ialah untulc mengkaji hubungan PM10 dengan fungsi paru-paru kanak-kanak tersebut. Seramai 51 orang kanak-/canak yang ringgal berhampiran kuari dan terdedah dengan debu kaur tehih dipilih, manakala 37 orang kanak-kanak yang tinggal berjauhan tetapi di daerah yang sama telah dipilih sebagai perbandingan untuk lag ian ini. Borang soalselidik telah digunakan untuk mendapatlcan maklumat latarbelakang dan sejarah respiratori dari ibu bapa kanalc-kanak terlibat. Fungsi paru-paru kanak-kanak pula diukur dengan menggunakan Pony Graphic S pirometer. Min kepekatan PM1 0 selama 24 jam di dalam rumah kediaman di kawasan terdedah ialah 76.66 (g/m3 dan di kawasan perbandingan 41 .55 (g/m3. Perbezaan kepekatan PM10 di antara kedua kawasan ini adalah signifikan (p=0.01). Hasil ujian fungsi paru-paru menunjukkan perbezaan yang signifikan di antara fungsi paru-paru kanalc-kanalc terdedah dengan kanak-kanak perbandingan dari segi FVC % jangkaan (t = -8.227, p = 0.01) dan FEV1 % jangkaan (t = -8.729, p = 0.01). Min fungsi paru-paru kanak-kanak lelaki di kawasan terdedah, (FVC % jangkaan = 68.05, FEV1 % jangkaan = 73.71) adalah lebih rendah daripada kawasan perbandingan (FVC % jangkaan= 89.78, FEV1 %~ jangkaan = 86.97). Min fungsi paru-paru kanak-kanak perempuan di kawasan terdedah (FVC % jangkaan= 69.64, FEV1 % jangkaan =74.90) juga adalah lebih rendah daripada hawasan perbandingan ( F VC % jangkaan = 90.99, FEV1 % jangkaan : 87 .7 9). Prevalens kejejasan parurparu FVC % jangkaan l
Introduction: A study on biological monitoring of lead on children was conducted when unleaded gasoline was widely used in 1998. The objectives were to monitor lead exposure using blood lead, urine d-aminolevulinic acid (d-ALA) and urine lead concentrations as biological indicators and to determine the relationship between these variables.
Methodology: Two hundred and sixty-nine school children, 169 from an urban school of Kuala Lumpur and 100 from an industrial school in southern Malaysia were selected for the study. These were Malay children in the age range of 61/2 to 81/2 years old. Blood and urine lead concentrations were analyzed using the Graphite Furnace Atomic Absorption Spectrophotometer. Urine d-ALA was measured with Spectrophotometer UV/VIS.
Results: The mean blood lead concentrations of the urban children (3.56 mg/dl) and the industrial children (3.75 mg/dl) were not significantly different (p=0.451). The urine d-ALA (urban=9.606; industrial=6.965 mg/g creatinine) and urine lead (urban=2.625; industrial=4.548 mg/g creatinine) of the urban children were significantly higher than the industrial children (p=0.014: p 10 mg/dl. About 78% of the urban children and 76% of the industrial children have urine d-ALA in a normal range (<0.6 mg/100ml) while 22% of the urban children and 24% of the industrial children were in the acceptable range (0.6 - 2.0 mg/100ml). All the children had normal urine lead concentrations (<8 mg/100ml).
Conclusion: These children were not highly exposed to lead as indicated by their blood lead, urine d-ALA and urine lead concentrations which were below the allowable standard in both study areas . This may be due to the total ban on leaded gasoline in the country since 1998 and as a result, the environmental lead exposure in these areas was quite low.
Keywords: Children's lead exposure, blood lead, urine lead, urine d-ALA
Distress thermometer (DT) is a single-item measure generated to assess the psychological distress among cancer patients. The aim of this study was to validate the translated DT as a tool to determine the psychological distress level and assess the factors associated with distress among the working breast cancer survivors and also to compare with the Hospital Anxiety and Depression Scale (HADS).
This study aimed to determine the relationship between blood lead (BPb) concentrations and cognitive and physical development in school children. A total of 169 urban children and 100 industrial children of Malay ethnicity, in the age range of 6(1/2) to 8(1/2) years, were selected. BPb was determined using GF atomic absorption spectrophotometer. The mean cognitive score (102.55) of the children from the industrial area was significantly higher than that of the urban children (95.09; P < .001). However, no significant differences were found in the BPb levels between the 2 groups (industrial, 3.75 microg/dL; urban, 3.56 microg/dL). There was significant inverse correlation between BPb and cognitive scores for all children (P < .05). The cognitive scores for all children were influenced by BPb after adjustments (P < .05). The urban children had significantly better Weight for Height and Left Arm Circumference values than those from industrial area. There was no significant correlation between BPb and the anthropometric measurements. In conclusion, low BPb influenced the cognitive development, whereas physical development was not affected.
Breast cancer is one of the commonest cancers among women in Malaysia. The relation between lifestyle practices and the risk of breast cancer in Chinese women aged 21-55 years were assessed using data collected from June to October 2001, via a face-to face interview in a case control study in the Breast Clinics of Kuala Lumpur Hospital and University Malaya Medical Centre. A total of 89 cases with breast cancer were compared with 85 controls without the disease. Our study showed that breastfeeding had an odds ratio of 4.43 after adjustment for confounders. The results add to the evidence of a protective association between breast feeding practices and breast cancer particularly among Chinese women receiving treatment at two government hospitals in the Klang Valley.
A cross-sectional study was carried out to determine the arsenic (As) and cadmium (Cd) concentrations in blood, urine, and drinking water as well as the health implications on 100 residents in an urban and a rural community. Results showed the blood As, urinary Cd, DNA damage, and water As and Cs were significantly (P < 0.001) higher in the rural community. Findings showed significant (P < 0.005) correlations between blood As and DNA damage with household income, years of residence, and total glasses of daily water consumption among the rural residents. The urinary NAG concentrations, years of residence, milk powder intake (glass/week), and seafood intake (per week) were significantly correlated (P < 0.005) with urinary Cd concentrations among respondents. In addition, urinary Cd level significantly influenced the urinary NAG concentrations (P < 0.001). The rural respondents experienced significantly higher lymphocyte DNA damage and blood As influenced by their years of residence and water consumption. The Cd in drinking water also resulted in the rural respondents having significantly higher urinary NAG which had a significant relationship with urinary Cd.