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  1. Pattern and predictors of soil-transmitted helminth reinfection among aboriginal schoolchildren in rural Peninsular Malaysia
    Hesham Al-Mekhlafi M, Surin J, Atiya AS, Ariffin WA, Mohammed Mahdy AK, Che Abdullah H
    Acta Trop, 2008 Aug;107(2):200-4.
    PMID: 18582430 DOI: 10.1016/j.actatropica.2008.05.022
    Data on soil-transmitted helminth (STH) infections and reinfection among Orang Asli (aborigine) schoolchildren and their nutritional and socioeconomic status were analyzed to investigate the pattern and the possible predictors of STH reinfection. In this longitudinal study, 120 (60 males and 60 females) Orang Asli primary schoolchildren aged 7-12 years and living in remote areas in Pos Betau, Kuala Lipis, Pahang were screened for the presence of STH using modified cellophane thick smear and Harada Mori techniques. The overall prevalence of ascariasis, trichuriasis and hookworm infections were 65.8, 97.5 and 10.8%, respectively. After complete deworming with a 3-day course of 400mg/daily of albendazole tablets, children were re-examined at 3 and 6 months from baseline. The reinfection rate, by one or more of STH species, at 3 months after deworming was high (49.5%) while 79.6% of the children were reinfected at 6 months after deworming. Logistic regression analyses showed that females, stunted children and those living in houses without toilets had significantly higher reinfection rates than others at 3 months (P<0.05). At 6 months, maternal employment status emerged as another predictor where children of working mothers had significantly higher reinfection rates (P=0.026). In conclusion, reinfection rate of STH is high and thus necessitates frequent and periodic deworming among children. Public health personnel need to re-look at the current control measures and identify innovative and integrated ways in order to reduce STH significantly in the rural communities.
    Matched MeSH terms: Ascaris lumbricoides/isolation & purification
  2. Soil-transmitted helminthic vaccines: Where are we now?
    Wong MTJ, Anuar NS, Noordin R, Tye GJ
    Acta Trop, 2023 Mar;239:106796.
    PMID: 36586174 DOI: 10.1016/j.actatropica.2022.106796
    It has been tested and proven that vaccination is still the best strategy to combat infectious diseases. However, to date, there are still no vaccines against human soil-transmitted helminthic diseases, despite their high prevalence globally, particularly in developing countries and rural areas with tropical climates and poor sanitation. The development of vaccines against helminths is riddled with obstacles. Helminths have a complex life cycle, multiple stages within the same host with stage-specific antigen expression, and the ability to regulate host immune reactions to evade the immune response. These elements contribute to the main challenge of helminthic vaccines: the identification of effective vaccine candidates. Therefore, this article reviews the current progress and potential future direction of soil-transmitted helminthic vaccines, particularly against Trichuris trichiura, Ascaris lumbricoides, Strongyloides stercoralis, Necator americanus and Ancylostoma duodenale. The study design employed was a systematic review, using qualitative meta-summary synthesis. Preclinical studies and clinical trials on the development of protein subunit vaccines against the five soil-transmitted helminths were searched on PubMed and Scopus. Effectiveness was indicated by a reduction in worm burden or larval output, an increase in specific IgG levels, or an increase in cytokine production. Our findings show that only the hookworm vaccine against N. americanus is in the clinical trial phase, while the rest is still in exploratory research and pre-clinical development phase.
    Matched MeSH terms: Ascaris lumbricoides
  3. Fulltext Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
    Tan PY, Loganathan R, Teng KT, Lee SC, Mohd Johari SN, Selvaduray KR, et al.
    Acta Trop, 2023 Apr;240:106860.
    PMID: 36775004 DOI: 10.1016/j.actatropica.2023.106860
    Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoolchildren (8-12 years old) with vitamin A deficiency (VAD) in rural areas of Malaysia to investigate the effects of red palm olein (RPO)-enriched biscuits on STH reinfection rates and infection intensities. The effects of the RPO-enriched biscuits (experimental group, n = 153) and palm olein (PO)-enriched biscuits (control group, n = 190), were assessed at 3- and 6-month after the administration of complete triple-dose albendazole (one dose of 400 mg for three consecutive days). The overall STH infection rate at baseline was recorded at 65.6%. At 6-month, a significantly lower reinfection rate of A. lumbricoides was observed in the experimental group (35.3%) compared to the control group (60.0%) (P0.05). These findings suggest the potential beneficial effects of RPO-enriched biscuit supplementation on the reinfection of A. lumbricoides, which could be attributed to its high carotenoids content by enhancing host immune response and mucosal epithelium integrity. However, further studies are warranted to confirm whether RPO supplementation could result in similar parasite-specific beneficial effects in other community settings, as well as to explore the underlying mechanisms.
    Matched MeSH terms: Ascaris lumbricoides
  4. An unusual presentation of acute cholecystitis: biliary ascariasis
    Amjad N, Nor AM, Singh H
    Hosp Med, 2001 Jun;62(6):370-1.
    PMID: 11436449
    Matched MeSH terms: Ascaris lumbricoides*
  5. Fulltext Helminthiasis among Indian preschoolers from urban areas in Penang
    Vikneswaran Sabramani, Halim Ismail, Asrul Abdul Wahab
    Int J Public Health Res, 2015;5(2):584-591.
    MyJurnal
    Introduction Helminthiasis is a common parasitic condition particularly among children in
    rural areas in developing countries where poor hygiene standard is practiced.
    The study aimed to determine the prevalence of helminthiasis among Indian
    preschoolers in urban areas in Penang and its associated factors.

    Methods A total of 194 urban Indian preschoolers aged 4 to 6 years old were selected
    randomly from 11 kindergartens in the state of Penang for this cross sectional
    study. Data collection was carried out in 2 phases. First, microscopic stool
    examinations were done to examine the presence of helminths. Second, self
    administered questionnaires which inquired about human, environment and
    socioeconomic factors were completed by the parents/guardians.

    Results The overall prevalence of helminthiasis was 7.2% and the most frequently
    encountered infective agent was Ascaris lumbricoides (57.1%) and followed
    by the tapeworms (42.86%). The logistic regression indicated that habitual
    thumb sucking (AOR= 5.6. 95%CI: 1.73-18.39) and families owning
    domestic pets (AOR= 3.2; 95%CI: 1.03-10.14) were the significant
    contributing factors to helminthiasis among the Indian pre-schoolers in urban
    Penang. Although the prevalence of helminth infection among the urban
    Indian preschoolers is lower than rural area, it is still a public health concern.
    Children habitual thumb sucking and rearing domestic pets at home were the
    significant contributing factors in helminthiasis.

    Conclusion Prevention strategy should focus on health education and promotion among
    adults and children, awareness on domestic animal hygiene and maintaining
    good environmental sanitation. Multi agency collaboration is clearly
    essential, especially between state health, education and veterinary
    departments in curbing this disease.
    Matched MeSH terms: Ascaris lumbricoides
  6. Fulltext An intestinal parasitological survey among the Jehai Orang Aslis (aborigines) of the Temenggor forest, Perak state, Malaysia
    Yaya Liliana Hanapian, Joon Wah Mak, Paul Chieh Yee Chen
    International e-Journal of Science, Medicine & Education, 2014;8(2):18-23.
    MyJurnal
    The Orang Aslis are indigenous minority peoples of Peninsular Malaysia, numbering 147,412 in 2003.Currently, the Orang Asli are divided into four language groupings namely the Northern Aslian, the Central Aslian, and the Southern Aslian groups, all of whom speak Austroasiatic languages; a fourth group in the South of Peninsular Malaysia speak a Malay dialect belonging to the Austronesian group of languages.This research was carried out on only one of the Northern Aslian group, the Jehai, who are also named Negritos based on their physical features. The Jehai live in the Belum and the Temenggor Forest that straddles Upper Perak and West Kelantan and until recently, were nomadic and lived by hunting-gathering.The World Health Organization (WHO) estimates that approximately two billion people worldwide are infected with the soil-transmitted nematode helminths,Ascaris lumbricoides, Trichuris trichiura and the hookworms Necator americanus and Ancylostoma duodenale, with 400 million of these infected being children of school age.Global numbers of A. lumbricoides infection have been estimated at about 1.5 billion cases. (Crompton, 2001). T. trichiura infection affects approximately 1,049 million people worldwide and an estimated 1.2 billion people are infected by hookworms. In Malaysia, the most common soil-transmitted helminth infections are A. lumbricoides, T. trichiura and hookworms.
    However, as there have been no extensive surveys on these infections, it is difficult to estimate with certainty the current overall incidence of infection with soil-transmitted helminths (STHs) among the Malaysian population.
    Matched MeSH terms: Ascaris lumbricoides
  7. Malnutrition and helminth infection among pre-school children in orang asli resettlement villages in Kelantan
    Zulkifli A, Khairul Anuar A, Atiya AS, Yano A
    JUMMEC, 1999;4:99-103.
    A survey of malnutrition and helminth infections among 268 pre-school children living in the Kuala Betis Orang Asli resttlement villages in Kelantan. The prevalence of helminth infections was 47.4% with Ascaris lumbricoides being the most common helminth (43.9%), followed by Trichuris trichiura (29.7%) and hookworm (6.3%). The prevalence of Ascaris lumbricoides and Trichuris trichiura infections increased with age, with the highest prevalence found in the 6-7 years age group. The overall prevalence of stunting, underweight and wasting were 61.7%, 60.4% and 17.5% respectively. Both stunting and underweight were significantly higher among the infected children. Factors associated with helminth infections in the pre-school children were older age group, poor water supply and households with more than 5 members. Rountine regular deworming is recommended based on the World Health Organisation recommendations for school children.
    Matched MeSH terms: Ascaris; Ascaris lumbricoides
  8. Immigrant Health Study. 5. Faecal pathogens in foreign workers. [Abstract]
    Suresh K, Rajah S, Khairul Anuar A, Anuar Zaini MZ, Saminathan R, Ramakrishnan S
    JUMMEC, 1998;3:62-63.
    One hundred seventy three stool samples were obtained from workers from Indonesia, Bangladesh, Myanmar, Pakistan and others. The stool samples were examined for Ascaris, Trichuris, Hookworm, Schistosomes, trematodes and cestodes. The protozaon parasites included Bnlantidiirrir coli, Blastocystis honlinis, Cyclospora cryptosporidium, Microsporidiirin, Entamoeeba histolytica, Giardia lamblia, lodamoeba butschilli. Of these 21.9%, 17% and 1% of the population studied had hookworm, Trichuris trichiura and Ascaris lumbricoides infections respectively. There was only one Indonesian reported to have Hymenolepis nana infections. The most common protozoan seen in the faecal sample is Blastocystis hominis (36%) followed by Giardia lamblia (4%). Most of the stools positive with these faecal pathogens were semisolid especially the ones positive for the protozoan. We have also shown Blastocystis from the Indonesian workers show very small forms almost 3-5 in size compared to the normal size of 10-15 pm in the other nationalities. These forms show a distinct growth profile in cultures and appears to be more resistant to temperature changes than Blastocystis seen in the other two nationalities. The high incidence of Hookworm and Trichuris infections is suggestive that if these workers are left unheated their productivity will be hampered by other possible serious complications such as anaemia, weight loss, abdominal pain with diarrhoea1 stools and nausea. There are increasing reports that Blastocystis hominis is pathogenic. Flatulence, abdominal discomfort and the increase in the frequency of the passing watery stool has been noted in patients infected with the parasite. Since most of the workers are generally housed in crowded rooms it is highly likely that this will facilitate transmission through the faecal-oral route of both Giardia and Blastocystis possibly increasing the incidences of these infections among workers.
    Matched MeSH terms: Ascaris; Ascaris lumbricoides
  9. Factors influencing the egg production of Ascaris lumbricoides: relationship to weight, length and diameter of worms
    Sinniah B, Subramaniam K
    J Helminthol, 1991 Jun;65(2):141-7.
    PMID: 1880388
    Fifty children aged 6 to 13 years and infected with Ascaris lumbricoides were selected for the study. The number of eggs laid daily by a female Ascaris increased with increase in its length, weight and diameter. Female worms became mature and started laying eggs when they reached a length of 118 mm. Adult female worms measuring 3.7 mm or more in diameter were found to be mature. The minimum weight of a worm producing eggs was 1.1 g. On average the number of eggs produced by the female decreased with increase in the worm load.
    Matched MeSH terms: Ascaris/anatomy & histology; Ascaris/physiology*
  10. A case of abscess of the liver due to Ascaris lumbricoides
    Rajahram SG
    Journal of the Malaya Branch of the British Medical Association, 1938;2:103.
    Matched MeSH terms: Ascaris lumbricoides
  11. Notes on two interesting cases
    Sivasambandan R
    Malayan Medical Journal, 1928;3:64.
    Matched MeSH terms: Ascaris lumbricoides
  12. Some unusual manisfestations of infection with Ascaris lumbricoides
    Kanagarayer K
    Malayan Medical Journal, 1927;2:23-4.
    Matched MeSH terms: Ascaris lumbricoides
  13. Ascaris lumbricoides in the Singapore garrison
    Walker JHC
    Malayan Medical Journal, 1927;2:148-50.
    Matched MeSH terms: Ascaris lumbricoides
  14. The health of the European child in Singapore and Malaya [duplicate2]
    Gordon GAC
    Malayan Medical Journal, 1928;3:32-40.
    Matched MeSH terms: Ascaris lumbricoides
  15. Acute haemorrhagic pancreatitis due to Ascaris lumbricoides
    Harrower G
    Malayan Medical Journal, 1933;8:295-8.
    Matched MeSH terms: Ascaris lumbricoides
  16. Biliary ascariasis: a wandering worm
    Lim, C.B., Munirah, A., Alias, M., Nandy, A.K., Thamby Dorai, C.R.
    Malaysian Journal of Paediatrics and Child Health, 2000;12(1):68-71.
    MyJurnal
    Ascaris lumbricoides infection usually results in mild gastrointestinal symptoms. However, heavy worm load infections can cause major complications. In one-third of the latter cases, the worms enter the bile duct causing cholangitis, biliary colic and acute pancreatitis. We describe an eleven-year-old Indian boy who presented with high grade fever, vomiting of worms, jaundice and right hypochondria! pain. Examination revealed an ill, malnourished and jaundiced child. His abdomen was tender with positive Murphy's sign and hepatomegaly. Urgent ultrasound showed hepatomegaly with dilated intrahepatic and common bile ducts (CBD). There were tubular echogenic filling defects with central sonolucency along the long axis of the CBD. He was fasted, started on intravenous fluids and broad spectrum antibiotics. As there was no improvement after 24 hours, endoscopic retrograde cholangio-pancreaticography (ERCP) was performed: it showed worms in the CBD. A stent was inserted to decompress the bile ducts and to ensure biliary drainage. The patient improved, the fever settled, jaundice resolved, serum amylase and transaminase levels normalised. It was planned to remove the stent at a later date.
    Matched MeSH terms: Ascaris lumbricoides
  17. Fulltext The health of Malaysia’s “Orang Asli” peoples: a review of the scientific evidence on nutritional outcome, parasite infestations, and discussion on implications for clinical practice
    Phua, K.L.
    Malaysian Journal of Public Health Medicine, 2015;15(1):0-0.
    MyJurnal
    The Orang Asli of Malaysia continue to experience poor health. There appears to be stagnation of certain aspect of their health status. Underweight (low weight-for-age) and stunting (low height-for-age) are significant amongst Orang Asli children. Worm infestation such as Ascaris, Trichuris and hookworm continue to afflict Orang Asli communities in Malaysia. Orang Asli communities can also be afflicted by other kinds of parasites, e.g. malaria parasites, microsporida parasites and Cryptosporidium parasites. Thus, primary care doctors who treat Orang Asli patients should be on the lookout for malnutrition and its effects (including anaemia, iodine deficiency, Vitamin A deficiency) as well as worm and parasite infestations. Such patients may need to undergo de-worming at regular intervals because of the tendency to get re-infected. Primary care doctors also need to be aware of possible interactions between infestations and nutritional deficiencies.
    Matched MeSH terms: Ascaris
  18. Fulltext Helminthiasis among primary rural school children in Bachok, Kelantan
    Anees, A.H., Zulkifli, A., Azmi, A., Syukri, M.
    Malaysian Journal of Public Health Medicine, 2003;3(2):19-22.
    MyJurnal
    A cross-sectional study on helminthiasis among rural primary schoolchildren aged 9 to 10 years Bachok, Kelaritan was perfumed. A total of 680 schoolchildren participated in the study. Stool specimens were examined for the presence of the ova of Ascaris lumbricoides, Trichuris trichiura and hoolcwonn. The worm load was then measured using the modified Stoll`s volumetric dilution
    technique. The overall prevalence of helminthiasis was 77 .2%. Trichuris trichiura were the commonest type of heminth noted - 66.8%, compared with Ascaris lumlrricoides (49.7%) and hookworm (1.8%). Mixed infections with Ascaris lumlyricoides and Trichuris trichiura was the commonest type of infection 249(41 .5%) . For Ascaris lumbncoides, 34.6% had mild and 5 I .3% had moderate worm load while for Trichurb trichiura, 66.5% had mild and 30.8 % had moderate worm load. Only 14.1% and 2.7% 4 of the schoolchildren had a heavy load of Ascaris lumlwicoides and Trichuris trichiura respectively. All the schookhildren with hookworm were only mildly infected. Targeted mass treatment for rural Mahysian schoolchildren is still essential, especially in areas where poverty and malnutrition are still prevalent.
    Matched MeSH terms: Ascaris; Ascaris lumbricoides
  19. Fulltext Ascariasis among orang asli children at pos lenjang, Pahang, malaysia
    Hartini, Y., Mohamed Kamel, A.G.
    Medicine & Health, 2010;5(2):60-65.
    MyJurnal
    A cross-sectional study was carried out in 2006 to determine the prevalence of Ascaris lumbricoides infection among Orang Asli (aborigines) children in Pos Lenjang, Pahang. A total of 71 faecal samples were collected from the children (40 girls and 31 boys) aged between 1-12 years. The samples were examined for the presence of the ova of A. lumbricoides using direct faecal smear and formalin-ether concentration techniques. 42.3%. The prevalence of A. lumbricoides infection was found to be slightly higher in males (45.2%) compared to females (40%) (p>0.05). The school-aged children showed higher prevalence of infection (48.6%) as compared to the preschool children (35.3%) (p
    Matched MeSH terms: Ascaris lumbricoides
  20. Fulltext Correlation between Soil Transmitted Helminth Infection and Eosinophil Levels among Primary School Children in Medan
    Darlan DM, Tala ZZ, Amanta C, Warli SM, Arrasyid NK
    Open Access Maced J Med Sci, 2017 Apr 15;5(2):142-146.
    PMID: 28507618 DOI: 10.3889/oamjms.2017.014
    BACKGROUND: Soil Transmitted Helminth infection is one of most prevalent health problems worldwide, especially in environments with poor sanitation. Based on World Health Organisation (WHO) data, more than 2 billion people, or 24% of the world's population, are infected with intestinal parasite. The highest prevalence is located in areas of poor sanitation and unsafe water supplies. In Indonesia, the prevalence of parasite infections is 15% of the entire population.

    AIM: The purpose of this study was to determine the relationship between Soil Transmitted Helminth infection on levels of eosinophils among primary school children. In addition, this study also aimed to determine the prevalence of different types of worm infections and the levels of eosinophils in children infected with worms.

    MATERIAL AND METHODS: This study was analytic observational using a cross-sectional method. The sampling technique was consecutive and in total 132 samples was obtained. The study involved primary school children in Amplas Medan and Hamparan Perak, Deli Serdang through May to October 2016. Univariate analysis was performed to determine STH infection prevalence and bivariate analysis was used to find the correlation between STH infection and eosinophil levels through a Chi square (χ2) test.

    RESULTS: The results showed that the prevalence of Soil Transmitted Helminth was 7.6%. The most common types of STH infection were 3.8% with Trichuris trichiura and 3% with Ascaris lumbricoides. A significant correlation was found between Parasite infection and eosinophil levels (Contingency Coefficient (C) = 0.2, χ2 = 5.3, p = 0.021) and the risk of STH infection that caused eosinophilia or increased eosinophil levels in the children with a Prevalence Ratio (PR) of 1.56 (Confidence Interval (CI) 95%: 1.10-2.22).

    CONCLUSION: It is recommended that schools at similar risk improve and maintain hygiene and healthy behaviour in the school environment and that parents and teachers pay greater attention to the cleanliness of their children.

    Matched MeSH terms: Ascaris lumbricoides
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