Displaying publications 1981 - 2000 of 2314 in total

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  1. Fulltext The differential expression of aqueous soluble proteins in breast normal and cancerous tissues in relation to ethnicity of the patients; Chinese, Malay and Indian
    Liang S, Singh M, Gam LH
    Dis Markers, 2010;28(3):149-65.
    PMID: 20534901 DOI: 10.3233/DMA-2010-0694
    Female breast cancer is one of the leading causes of female mortality worldwide. In Malaysia, breast cancer is the most commonly diagnosed cancer in women. Of the women in Malaysia, the Chinese have the highest number of breast cancer cases, followed by the Indian and the Malay. The most common type of breast cancer is infiltrating ductal carcinoma (IDC). A proteomic approach was applied in this study to identify changes in the protein profile of cancerous tissues compared with normal tissues from 18 patients; 8 Chinese, 6 Malay and 4 Indian were analysed. Twenty-four differentially expressed hydrophilic proteins were identified. We evaluated the potential of these proteins as biomarkers for infiltrating ductal carcinoma based on their ethnic-specific expressions. Three of the upregulated proteins, calreticulin, 14-3-3 protein zeta and 14-3-3 protein eta, were found to be expressed at a significantly higher level in the cancerous breast tissues when compared with the normal tissues in cases of infiltrating ductal carcinoma. The upregulation in expression was particularly dominant in the Malay cohort.
    Matched MeSH terms: China
  2. Population diversity of Diaphorina citri (Hemiptera: Liviidae) in China based on whole mitochondrial genome sequences
    Wu F, Jiang H, Beattie GAC, Holford P, Chen J, Wallis CM, et al.
    Pest Manag Sci, 2018 Nov;74(11):2569-2577.
    PMID: 29688605 DOI: 10.1002/ps.5044
    BACKGROUND: Diaphorina citri (Asian citrus psyllid; ACP) transmits 'Candidatus Liberibacter asiaticus' associated with citrus Huanglongbing (HLB). ACP has been reported in 11 provinces/regions in China, yet its population diversity remains unclear. In this study, we evaluated ACP population diversity in China using representative whole mitochondrial genome (mitogenome) sequences. Additional mitogenome sequences outside China were also acquired and evaluated.

    RESULTS: The sizes of the 27 ACP mitogenome sequences ranged from 14 986 to 15 030 bp. Along with three previously published mitogenome sequences, the 30 sequences formed three major mitochondrial groups (MGs): MG1, present in southwestern China and occurring at elevations above 1000 m; MG2, present in southeastern China and Southeast Asia (Cambodia, Indonesia, Malaysia, and Vietnam) and occurring at elevations below 180 m; and MG3, present in the USA and Pakistan. Single nucleotide polymorphisms in five genes (cox2, atp8, nad3, nad1 and rrnL) contributed mostly in the ACP diversity. Among these genes, rrnL had the most variation.

    CONCLUSION: Mitogenome sequences analyses revealed two major phylogenetic groups of ACP present in China as well as a possible unique group present currently in Pakistan and the USA. The information could have significant implications for current ACP control and HLB management. © 2018 Society of Chemical Industry.

    Matched MeSH terms: China
  3. Fulltext Proceedings of the 3rd expert consultation and planning meeting on infant and young child nutrition-(part 2)
    Amarra, Sofia, Chan, Pauline
    Malays J Nutr, 2013;19(1):139-142.
    MyJurnal
    Introduction: The Infant and Early Childhood Nutrition Task Force, International Life Sciences Institute Southeast Asia (ILSI SEA) Region, organised the 1st and 2nd Expert Consultation and Planning Meeting on Infant and Early Childhood Nutrition in 2009 and 2011, respectively. The goal of the consultations was “to generate and promote relevant science-based information that will help improve nutritional status, growth and development of infants and young children in Southeast Asia.” Methods: An Expert Panel Core Group was created whose role is to provide advice and recommendations through a review of current scientific knowledge regarding issues related to early childhood growth and nutrition. The Panel is composed of experts representing 7 countries (China, Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam). In July 2012, the Panel convened the 3rd Expert Consultation and Planning Meeting on Infant and Young Child Nutrition in Singapore. This report presents the highlights of the meeting and recommendations made by the Panel on ways to improve infant and young child nutrition in Southeast Asia. Results and Conclusion: The effective use of WHO indicators for assessing infant and young child feeding practices, mitigating the effects of maternal employment on breastfeeding, using behaviour change communication, updating the education of health personnel, and improving maternal health were considered important actions to be taken. Since current feeding practices in Southeast Asia fall short of WHO recommendations, studies are needed to develop strategies which take into consideration the diverse cultural settings that characterise the region.
    Matched MeSH terms: China
  4. The Immunomodulating Properties of Tiger Milk Medicinal Mushroom, Lignosus rhinocerus TM02® Cultivar (Agaricomycetes) and Its Associated Carbohydrate Composition
    Sum AYC, Li X, Yeng YYH, Razif MFM, Jamil AHA, Ting NS, et al.
    Int J Med Mushrooms, 2020;22(8):803-814.
    PMID: 33389874 DOI: 10.1615/IntJMedMushrooms.2020035658
    Natural compounds found in Lignosus rhinocerus like polysaccharides and polysaccharide-protein complexes have the capabilities to modulate the immune system. It possesses antitumor and anti-inflammatory properties and is commonly used in Southeast Asia and Southern China to alleviate illness. To investigate its immunomodulating properties, composition of polysaccharides and the expression of cytokines/chemokines from L. rhinocerus (TM02®) cultivar treated RAW 264.7 were explored. It was revealed, CWE contains linear polysaccharides with 1,4-linkages and rhinoprolycan fraction (HMW & MMW) possesses 1,4-Glcp and 1,6-Glcp backbone and branched chain (1,3,6-Glcp, 1,4,6-Glcp, 1,3,6-Glcp, 1,2,4,6-Glcp). Cytokines profile showed upregulation from CWE (IL-5: 12.078 ± 1.225), HMW (IL-6: 7.297 ± 0.338; TIMP-1: 3.358 ± 0.200), MMW (IL-5: 15.412 ± 5.823; TIMP-1: 1.747 ± 0.053), and LMW (MIP-2: 3.495 ± 0.416; TIMP-1: 7.573 ± 0.088) and possible involvement of NF-κB and MAPK signaling pathway. Further in vivo studies are needed to fully understand the immunomodulatory effects of TM02®.
    Matched MeSH terms: China
  5. Molecular detection of Trypanosoma evansi based on ITS1 rDNA gene in Camelus dromedarius in Sistan Region, Iran
    Zangooie F, Ganjali M, Keighobadi M, Nabavi R
    Trop Biomed, 2018 Dec 01;35(4):1140-1147.
    PMID: 33601861
    Trypanosomiasis is a disease caused by a flagellate protozoon called Trypanosoma and can be mechanically transmitted by vectors to humans and animals. Various species of Trypanosoma are found in livestock and poultry, which include Trypanosoma evansi, T. brucei, T. vivax and T. congolense. The camel is the most sensitive livestock for T. evansi, so the exact identification of infection is very important for epidemiological studies and the design of control programs. The present study was conducted with the aim of molecular detection of camel trypanosomiasis in the Sistan region in 2015. Previous studies have shown that internal transcribed spacer one (ITS1) of the ribosomal DNA is a reliable genetic marker for carrying out systematic molecular studies of trypanosomes. In order to investigate infections of camels with T. evansi, a total of 113 blood samples were collected randomly and the presence of parasites in each sample was evaluated using the microscopic method and polymerase chain reaction (PCR) test. Genomic DNA was extracted and the ITS-1 was amplified by PCR. In comparison to the nucleotide sequence obtained with the sequences recorded in GenBank, it was determined that there is a 99% homology with the recorded sequence of T. evansi. The obtained sequence was registered in Gen Bank with kx900449 code. The T. evansi sequences from different countries such as India, Taiwan, Thailand, the Philippines, China and Argentina and etc., were extracted from the Gene bank and aligned using the ClustalW2 sequence alignment tool and MEGA software. In this study the prevalence of T. evansi infection using the molecular method was 6.19% and no positive samples were found by microscopic observation.
    Matched MeSH terms: China
  6. Dense populations of the microsporidian Enterocytozoon hepatopenaei (EHP) in feces of Penaeus vannamei exhibiting white feces syndrome and pathways of their transmission to healthy shrimp
    Tang KFJ, Han JE, Aranguren LF, White-Noble B, Schmidt MM, Piamsomboon P, et al.
    J Invertebr Pathol, 2016 Oct;140:1-7.
    PMID: 27530403 DOI: 10.1016/j.jip.2016.08.004
    White feces syndrome (WFS) is an emerging problem for penaeid shrimp farming industries in SE Asia countries, Thailand, Malaysia, Vietnam, Indonesia, China, and in India. This occurrence of this syndrome is usually first evidenced by the appearance of white fecal strings floating on surface of the shrimp ponds. The gross signs of affected shrimp include the appearance of a whitish hindgut and loose carapace, and it is associated with reduced feeding and growth retardation. To investigate the nature of the white feces syndrome, samples of white feces and shrimp hepatopancreas tissue were collected from Penaeus vannamei in affected farms in Indonesia, and these were examined histologically. Within the white feces, we found densely packed spores of the microsporidian Enterocytozoon hepatopenaei (abbreviated as EHP) and relatively fewer numbers of rod-shaped bacteria. From WFS ponds, hepatopancreas samples form 30 individual shrimp were analyzed by histology and in situ hybridization. The results showed that all of the shrimp examined were infected with EHP accompanied by septic hepatopancreatic necrosis (SHPN). Midgut epithelial cells were also infected and this increased the number of tissue types being affected by EHP. By PCR, EHP was detected in all the samples analyzed from WFS-affected ponds, but not in those sampled from healthy shrimp ponds. To determine the modes of transmission for this parasite, we performed feeding and cohabitation bioassays, the results showed that EHP can be transmitted through per os feeding of EHP-infected hepatopancreas tissue to healthy shrimp and through cohabitation ofinfected and healthy shrimp. In addition, we found the use of Fumagillin-B, an antimicrobial agent, was ineffective in either reducing or eliminating EHP in infected shrimp.
    Matched MeSH terms: China
  7. Fulltext Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives
    Tan HL, Chan KG, Pusparajah P, Saokaew S, Duangjai A, Lee LH, et al.
    Front Pharmacol, 2016;7:191.
    PMID: 27445824 DOI: 10.3389/fphar.2016.00191
    Epimedium (family Berberidaceae), commonly known as Horny Goat Weed or Yin Yang Huo, is commonly used as a tonic, aphrodisiac, anti-rheumatic and anti-cancer agent in traditional herbal formulations in Asian countries such as China, Japan, and Korea. The major bioactive compounds present within this plant include icariin, icaritin and icariside II. Although it is best known for its aphrodisiac properties, scientific and pharmacological studies suggest it possesses broad therapeutic capabilities, especially for enhancing reproductive function and osteoprotective, neuroprotective, cardioprotective, anti-inflammatory and immunoprotective effects. In recent years, there has been great interest in scientific investigation of the purported anti-cancer properties of icariin and its derivatives. Data from in vitro and in vivo studies suggests these compounds demonstrate anti-cancer activity against a wide range of cancer cells which occurs through various mechanisms such as apoptosis, cell cycle modulation, anti-angiogenesis, anti-metastasis and immunomodulation. Of note, they are efficient at targeting cancer stem cells and drug-resistant cancer cells. These are highly desirable properties to be emulated in the development of novel anti-cancer drugs in combatting the emergence of drug resistance and overcoming the limited efficacy of current standard treatment. This review aims to summarize the anti-cancer mechanisms of icariin and its derivatives with reference to the published literature. The currently utilized applications of icariin and its derivatives in cancer treatment are explored with reference to existing patents. Based on the data compiled, icariin and its derivatives are shown to be compounds with tremendous potential for the development of new anti-cancer drugs.
    Matched MeSH terms: China
  8. Nutrient fluxes across sediment-water interface in Bohai Bay Coastal Zone, China
    Mu D, Yuan D, Feng H, Xing F, Teo FY, Li S
    Mar Pollut Bull, 2017 Jan 30;114(2):705-714.
    PMID: 27802871 DOI: 10.1016/j.marpolbul.2016.10.056
    Sediment cores and overlying water samples were collected at four sites in Tianjin Coastal Zone, Bohai Bay, to investigate nutrient (N, P and Si) exchanges across the sediment-water interface. The exchange fluxes of each nutrient species were estimated based on the porewater profiles and laboratory incubation experiments. The results showed significant differences between the two methods, which implied that molecular diffusion alone was not the dominant process controlling nutrient exchanges at these sites. The impacts of redox conditions and bioturbation on the nutrient fluxes were confirmed by the laboratory incubation experiments. The results from this study showed that the nutrient fluxes measured directly from the incubation experiment were more reliable than that predicted from the porewater profiles. The possible impacts causing variations in the nutrient fluxes include sewage discharge and land reclamation.
    Matched MeSH terms: China
  9. Fulltext Food security : the needs for international treaty on plant genetic resources to ensure smoother flow of genes
    Mohd Shukor, N.
    Buletin Persatuan Genetik Malaysia, 2010;16(1):15-17.
    MyJurnal
    Never in the history of modern Malaysia, the general population at all levels are being threatened by food security. Food becoming less available and more expensive. Many factors, both long- and short-term, have contributed to the shortage. At a global level, available data seems to indicate that we have been consuming more than what we produce. Then came the shortfall in global rice production caused by the impact of climate change such as the widespread drought in India and China in 2002, typhoons in the Philippines in 2006, and the major flooding in Bangladesh in 2007. This was followed by the returns of pests such as planthoppers, and the various virus diseases transmitted particularly at regions with growing seasons having abnormally higher temperatures caused by climate change. Since the crisis started, scientists particularly breeders all over the world were requested to strengthen and upgrade the breeding program and facilities for the development of new varieties with increased tolerance to drought, flooding, and salinity as well resistant to insects and diseases. An important pre-requisite for such activities is the free flow of plant genetic resources for food and agriculture (pgrfa). The adoption of the Convention on Biological Diversity (CBD) has drastically slowed down the movement of many plant genetic resources and this has threatened the future supply of food. The International Treaty on Plant Genetic Resource for Food and Agriculture (ITPGRFA or the Treaty) is a global reaction to the rising tide of measures taken by many governments as a result CBD to extend their sovereign control over genetic resources. Many countries felt that those measures are inappropriate for food and agricultural crop genetic resources. The Treaty on the other hand recognizes that access and benefit sharing for agricultural biodiversity must be treated differently from the way it is generally treated under CBD. This paper discusses some of the key points and provisions from the treaty and some issues arising from its negotiation and future implementation in Malaysia.
    Matched MeSH terms: China
  10. Nasopharyngeal carcinoma and histocompatibility antigens
    Simons MJ, Chan SH, Wee GB, Shanmugaratnam K, Goh EH, Ho JH, et al.
    IARC Sci Publ, 1978.
    PMID: 730194
    New data are presented concerning the relationship between NPC and HLA antigens among Chinese. When attention is confined to newly diagnosed cases, it can be shown that, apart from the increased risk associated with the joint occurrence of A2 and B-Sin 2, there is also an increased risk associated with BW17 and a decrease in risk associated with A11. Among long-term survivors, however, BW17 is appreciably decreased, whereas A2 in the absence of B-Sin 2 or BW17 is increased. Among Malays, a non-Chinese group, there is an excess among NPC patients of a locus A blank, a blank which is probably associated with the AW19 complex.
    Matched MeSH terms: China
  11. The coracoclavicular joint
    Cockshott WP
    Radiology, 1979 May;131(2):313-6.
    PMID: 441311
    The coracoclavicular joints are genetically determined anatomic variants. There are problems in determining their presence by dissection examination of osteologic material as well as by radiography. Based on a survey of published material and a prospective radiological survey carried out in Malaysia, it is clear that the anomaly is more frequent in Asia than in Europe and Africa. There is a high incidence in people from Southern China. The joints are subject to osteophytic marginal lipping without development of symptoms or disability.
    Matched MeSH terms: China
  12. The prevalence of dens evaginatus
    Yip WK
    Oral Surg. Oral Med. Oral Pathol., 1974 Jul;38(1):80-7.
    PMID: 4525999
    Matched MeSH terms: China
  13. Bilateral renal calculi
    Sreenevasan G
    Ann R Coll Surg Engl, 1974 Jul;55(1):3-12.
    PMID: 4845653
    Bilateral renal calculi were present in 114 (10.7%) of 1,070 cases of proved urinary calculus admitted to the Urological Department of the General Hospital, Kuala Lumpur, during the period November 1968-May 1973. The management of bilateral renal calculi is discussed with reference to the first 100 cases in this series. The introduction of renography has greatly facilitated the decision as to which kidney should be operated on first. The management of patients with and without uraemia is discussed and the use of the modified V and V-Y incisions for the removal of staghorn calculi is described. Complications and results are briefly reviewed.
    Matched MeSH terms: China
  14. The incidence and racial distribution of pterygium in West Malaysia
    Rasanayagam RT
    Trans Ophthalmol Soc N Z, 1973;25:56-9.
    PMID: 4519231
    Matched MeSH terms: China
  15. Erythrocyte G-6-PD deficiency among Chinese and Malays of Singapore
    Saha N, Banerjee B
    Trop Geogr Med, 1971 Jun;23(2):141-4.
    PMID: 5568538
    Matched MeSH terms: China
  16. Interpersonal communication and the diffusion of family planning in West Malaysia
    Palmore JA, Hirsch PM, Ariffin Bin Marzuki
    Demography, 1971 Aug;8(3):411-25.
    PMID: 4950540 DOI: 10.2307/2060629
    Matched MeSH terms: China
  17. [Primary liver carcinoma. Review]
    Korenek J
    Vnitr Lek, 1970 Apr;16(4):371-8.
    PMID: 4910163
    Matched MeSH terms: China
  18. IMAGE OF DENTISTRY: UNITED STATES, AMERICAS, ASIAN PACIFIC, AND UNION OF SOVIET SOCIALIST REPUBLICS
    HILLENBRAND H
    J Am Dent Assoc, 1964 Feb;68:241-9.
    PMID: 14125036
    Matched MeSH terms: China
  19. JUVENILE DELINQUENCY IN SINGAPORE
    MURPHY HB
    J Soc Psychol, 1963 Dec;61:201-31.
    PMID: 14084801
    Matched MeSH terms: China
  20. The epidemiology of chronic myeloid leukaemia in southern Sarawak, Borneo Island
    Kuan JW, Melaine Michael S
    Med J Malaysia, 2018 04;73(2):78-85.
    PMID: 29703870 MyJurnal
    OBJECTIVES: There are very few published chronic myeloid leukaemia (CML) epidemiology studies in South-East Asia and no representative from Malaysia.

    METHODS: This is a cross-sectional study of adult CML patients (citizen) in a single but representative centre in southern Sarawak.

    RESULTS: Total 79 patients (Malay 39%, Chinese 30.4%, Iban 17.7%, Bidayuh 12.7%) were identified from the databases. Median age at diagnosis was younger, 40, compared to developed countries due to population structure. M:F ratio was higher, 2.6:1 compared to other countries 1.3-1.7:1. Majority presented at chronic phase (89.5%), low/intermediate risk score (80%) and started imatinib (96%) as first line tyrosine kinase inhibitor (TKI), which 40% of them switched to other TKI due to intolerance (17%) and failure (including disease progression)/not achieving major molecular response (83%). Quantitative polymerase chain reaction (qPCR) assessment after three months of TKI treatment had higher positive predictive value to predict Imatinib failure, 75%, than qPCR assessment after six months of TKI treatment, 58%. Presenting phase, symptoms, signs and laboratory data were like most countries. Estimated prevalence and incidence of CML in southern Sarawak was 69.2/1,000,000 population at the Year 2016 (similar to most developing countries) and 8.0/1,000,000 population per year at the Year 2011-2016 (similar to most countries), respectively. The incidence increased with age and was lowest among Iban, 12.8 and highest among Chinese, 19.5, which was 4x higher than Chinese in China. The prevalence of different BCR-ABL1 transcript type was like other Asia countries CONCLUSION: Significant epidemiological differences on M:F ratio and ethnic groups compared to other countries warrant further study.

    Matched MeSH terms: China
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