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Fulltext Body composition and risk factors for cardiovascular disease in global multi-ethnic populations

Carter JL, Abdullah N, Bragg F, Murad NAA, Taylor H, Fong CS, et al.

Int J Obes (Lond), 2023 Sep;47(9):855-864.
PMID: 37460680 DOI: 10.1038/s41366-023-01339-9

BACKGROUND: No large-scale studies have compared associations between body composition and cardiovascular risk factors across multi-ethnic populations.
METHODS: Population-based surveys included 30,721 Malay, 10,865 Indian and 25,296 Chinese adults from The Malaysian Cohort, and 413,737 White adults from UK Biobank. Sex-specific linear regression models estimated associations of anthropometry and body composition (body mass index [BMI], waist circumference [WC], fat mass, appendicular lean mass) with systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), triglycerides and HbA1c.
RESULTS: Compared to Malay and Indian participants, Chinese adults had lower BMI and fat mass while White participants were taller with more appendicular lean mass. For BMI and fat mass, positive associations with SBP and HbA1c were strongest among the Chinese and Malay and weaker in White participants. Associations with triglycerides were considerably weaker in those of Indian ethnicity (eg 0.09 [0.02] mmol/L per 5 kg/m2 BMI in men, vs 0.38 [0.02] in Chinese). For appendicular lean mass, there were weak associations among men; but stronger positive associations with SBP, triglycerides, and HbA1c, and inverse associations with LDL-C, among Malay and Indian women. Associations between WC and risk factors were generally strongest in Chinese and weakest in Indian ethnicities, although this pattern was reversed for HbA1c.
CONCLUSION: There were distinct patterns of adiposity and body composition and cardiovascular risk factors across ethnic groups. We need to better understand the mechanisms relating body composition with cardiovascular risk to attenuate the increasing global burden of obesity-related disease.

Matched MeSH terms: Ethnic Groups*
Latah: the symbolism of a putative mental disorder

Kenny MG

Cult Med Psychiatry, 1978 Sep;2(3):209-31.
PMID: 710172

This paper examines the symbolic properties and cultural relevance of latah, a behavioral state noted in Malay and Indonesia since the 19th Century. Most interpretations of latah have been psychological, latah being perceived as a 'mental disorder.' In the following, it is concluded that latah is intimately related to other aspects of Malayo-Indonesian culture and that it is a well-known cultural pattern and not a mental disorder as such, though it may occur among persons, largely women, in a socially and psychologically marginal situation. Latah is a symbolic representation of marginality, and it is as appropriate to certain mythological and religious figures to the socially marginal.

Matched MeSH terms: Ethnic Groups*
Fulltext The spectrum of beta-thalassemia mutations in Malays in Singapore and Kelantan

Abdullah WA, Jamaluddin NB, Kham SK, Tan JA

Southeast Asian J Trop Med Public Health, 1996 Mar;27(1):164-8.
PMID: 9031421

The spectrum of beta-thalassemia mutations in Malays in Singapore and Kelantan (Northeast Malaysia) was studied. Allele specific priming was used to determine the mutations in beta-carriers at -28, Codon 17, IVSI #1, IVSI #5, Codon 41-42 and IVSII #654 along the beta-globin gene. The most common structural hemoglobin variant in Southeast Asia, Hb E, was detected by DNA amplification with restriction enzyme (Mnl1) analysis. Direct genomic sequencing was carried out to detect the beta-mutations uncharacterized by allele-specific priming. The most prevalent beta-mutations in Singaporean Malays were IVSI #5 (45.83%) followed by Hb E (20.83%), codon 15 (12.5%) and IVSI #1 and IVSII #654 at 4.17% each. In contrast, the distribution of the beta-mutations in Kelantan Malays differed, with Hb E as the most common mutation (39.29%) followed by IVSI #5 (17.86%), codon 41-42 (14.29%), codon 19 (10.71%) and codon 17 (3.57%). The beta-mutations in Kelantan Malays follow closely the distribution of beta-mutations in Thais and Malays of Southern Thailand and Malays of West Malaysia. The AAC-->AGC base substitution in codon 19 has been detected only in these populations. The spectrum of beta-mutations in the Singaporean Malays is more similar to those reported in Indonesia with the beta-mutation at codon 15 (TGG-->TAG) present in both populations. The characterization of beta-mutations in Singaporean and Kelantan Malays will facilitate the establishment of effective prenatal diagnosis programs for beta-thalassemia major in this ethnic group.

Matched MeSH terms: Ethnic Groups/genetics*
Serum immunoglobulin levels in the Malaysian Orang Asli

Yadav M, Shah FH, Dhaliwal SS

Southeast Asian J Trop Med Public Health, 1978 Dec;9(4):501-9.
PMID: 751216

Serum immunoglobulin G, A, M, D and E levels were determined in the forest-dwelling Orang Asli of age group 8 to 64 years. The levels are higher than observed for urban Malaysians and comparable to levels reported for populations residing in the tropics. There was no significant difference in serum levels of all the immunoglobulins studied in both sexes. The elevated serum immunoglobulins levels are discussed in terms of the nature of the immune defence developed in the Orang Asli to contend with the many parasites prevalent in their environment.

Matched MeSH terms: Ethnic Groups*
The impact of poverty on fertility in Peninsular Malaysia: a cohort analysis

Teo P

GeoJournal, 1991 Feb;23(2):125-33.
PMID: 12317879
Matched MeSH terms: Ethnic Groups*
Fulltext Prevalence and severity of anaemia among the Temiar sub-ethnic indigenous Orang Asli communities in Kelantan, Peninsular Malaysia

Idris ZM, Wahid W, Seri Rakna MIM, Ghazali N, Hassan NW, Abdul Manap SNA, et al.

Front Public Health, 2024;12:1412496.
PMID: 39171304 DOI: 10.3389/fpubh.2024.1412496

INTRODUCTION: Anaemia remains a primary concern of public health in developing countries. Indigenous populations are a significant and frequently underreported group at risk for anaemia. This study aimed to assess the prevalence of anaemia and identify its determinants in the Temiar sub-ethnic indigenous Orang Asli (OA) community in Peninsular Malaysia.
METHODOLOGY: A community-based cross-sectional study was conducted among 640 indigenous Temiar OA participants from a remote settlement in Gua Musang, Kelantan, Malaysia. Data was collected using face-to-face interviews with a standardised pretested questionnaire and through blood samples collected for haemoglobin (Hb) testing. Anaemia status was determined using the Hb level cut-off established by the World Health Organization (WHO). Descriptive analysis was used to determine the prevalence of anaemia, while multiple logistic regression was used to determine factors associated with anaemia.
RESULTS: The overall anaemia prevalence was 44.7% (286/640), and the prevalence rates of mild, moderate and severe anaemia were 42.7, 50.7 and 6.6%, respectively. Anaemia-specific prevalence varied significantly by age group (p 40 (aOR 0.25, p

Matched MeSH terms: Ethnic Groups/statistics & numerical data
Restriction fragment length polymorphism (RFLP) at the DNF15S2 locus in three ethnic groups of Singapore

Saha N, Tay JS, Carritt B

Hum Hered, 1990;40(4):250-2.
PMID: 1974242

Three different ethnic groups from Singapore comprising 79 Chinese, 34 Malays and 23 Indians of Dravidian origin, were investigated for the HindIII RFLP at the DNF15S2 locus. The three populations had very similar allele frequencies and the frequency of rarer(S) allele was significantly (p less than 0.01) lower (0.21) in these ethnic groups compared to that in Caucasians (0.41). The phenotypic distributions were at Hardy-Weinberg equilibrium.

Matched MeSH terms: Ethnic Groups*
Mitochondrial malic enzyme polymorphism among different ethnic groups in Singapore

Bhattacharyya SP, Saha N

Hum Hered, 1984;34(6):393-5.
PMID: 6510935

Mitochondrial malic enzyme (EC 1.1.1.40; MEM) was examined by starch-gel electrophoresis on post-mortem brain samples from 453 unrelated subjects of either sex comprising 161 Chinese, 150 Indians and 113 Malays and 29 from other racial groups. The estimated gene frequencies of MEM1 were found to be 0.7111, 0.6100 and 0.6769 in Chinese, Indians and Malays, respectively. No significant deviation from the Hardy-Weinberg equilibrium was observed in Chinese and Malays. However, there was a significant deviation with a deficiency of heterozygotes among Indians. MES did not show any polymorphism.

Matched MeSH terms: Ethnic Groups*
HLA-DQ alpha genotype and allele frequencies in Malays, Chinese, and Indians in the Malaysian population

Koh CL, Benjamin DG

Hum Hered, 1994 May-Jun;44(3):150-5.
PMID: 8039798

The HLA-DQ alpha genotype and allele frequencies in 130 Malays, 125 Chinese, and 137 Indians in the Malaysian population were determined using a commercial HLA-DQ alpha DNA amplification and typing kit which distinguishes 6 alleles (DQA1.1, DQA1.2, DQA1.3, DQA2, DQA3, and DQA4) and 21 possible genotypes at this locus. All 21 genotypes were encountered in the Malay and Indian samples, but DQA1.1,DQA1.3 and DQA2,DQA2 genotypes were absent in the Chinese sample. In all three ethnic groups, the numbers observed for the various DQ alpha genotypes were in accordance with those expected from Hardy-Weinberg equilibrium. The allele frequencies observed in these three groups were significantly different to allow them to be distinguished as distinct populations. For the Malays, Chinese, and Indians, heterozygosity values at this locus were 0.77, 0.77, and 0.83, respectively, and values of the power of discrimination were 0.91, 0.90, and 0.94, respectively. These population data will enable the HLA-DQ alpha locus to be used as a marker in forensic identity testing in Malaysia.

Matched MeSH terms: Ethnic Groups/genetics
Fulltext Impact of Hofstede's cultural dimensions on sustainable competitive advantage: The mediating role of entrepreneurial innovativeness among Malaysian ethnic entrepreneurs

Poulova P, Wang H, Lin S, Wu X, Tehseen S, Liu X

Acta Psychol (Amst), 2024 Nov;251:104538.
PMID: 39579499 DOI: 10.1016/j.actpsy.2024.104538

This study investigated the impact of Hofstede cultural dimensions on sustainable competitive advantage with the mediating role of entrepreneurial innovativeness among Malays, Malaysian Chinese, and Malaysian Indian entrepreneurs in the retail industry. This study involved a quantitative approach with standardized questionnaires distributed among target respondents through non-probability sampling techniques, including snowball sampling, quota sampling, and convenience sampling. The data were collected in a cross-sectional setting from Malaysian retail ethnic entrepreneurs. AMOS-SEM and SPSS were used to analyze the data. The findings of this study revealed a positive and significant influence of indulgence, long-term orientation, masculinity, and low power distance on sustainable competitive advantage among Chinese, Malay, and Indian entrepreneurs. Furthermore, the direct effect of entrepreneurial innovativeness was also positive and significant in terms of sustainable competitive advantage among Chinese, Malay, and Indian entrepreneurs. Finally, the indirect effects of collectivism, indulgence, low uncertainty avoidance, low power distance, masculinity, and long-term orientation on sustainable competitive advantage through mediator entrepreneurial innovativeness were positive and significant among Malaysian Chinese. However, in Malay (indulgence) and India (collectivism, low uncertainty avoidance, and low power distance), these were not significant. Our results suggest that academics and businesses should consider how cultural norms of masculinity, long-term orientation, and uncertainty avoidance impact sustainable competitive advantage activities. Rewards encouraging sustainable competitive advantage in one subculture may not promote it in another. Subcultural norms influence entrepreneurs' decisions, expectations, and incentives in a culturally diverse community.

Matched MeSH terms: Ethnic Groups/psychology
Physical activity in Chinese, Malays and Indians in Singapore

Hughes K, Yeo PP, Lun KC, Thai AC, Wang KW, Cheah JS

Ann Acad Med Singap, 1990 May;19(3):326-9.
PMID: 2393230

A population based survey has measured levels of physical activity by questionnaire in persons aged 18 to 69 years in Singapore. Levels of physical activity were classified into high, medium and low based on activity in leisure and at work. The only ethnic difference was that for males a higher proportion were classified as "high" activity in Malays (24.8%) than Chinese (16.0%) and Indians (18.1%). For the overall 18 to 69 age group, it was found that for males, the proportions in the "low" category were Chinese 80%, Malays 70% and Indians 75% while for females it was 95% in all three ethnic groups. As physical activity of sufficient intensity is important in disease prevention and health promotion, more needs to be done on educating the public in Singapore about the benefits of regular exercise.

Matched MeSH terms: Ethnic Groups*
Pulmonary function in healthy Chinese, Malay and Indian adults in Singapore

Chia SE, Wang YT, Chan OY, Poh SC

Ann Acad Med Singap, 1993 Nov;22(6):878-84.
PMID: 8129348

Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEFR), single-breath diffusion capacity measurements (effective alveolar volume (VA), carbon monoxide transfer factor (DLCO) and transfer coefficient (KCO)) were determined in 452 healthy Singaporean adults (277 males and 175 females) aged 20-70 years. The ratio of Chinese, Malay and Indian subjects was 5:2:3 in both sexes. Age, height and weight in the males were all significantly correlated with FEV1, FVC, DLCO, VA and PEFR. However, for females, only age and height were significantly correlated with the studied lung function parameters. Significant ethnic differences were observed for most of the pulmonary functions (except KCO and PEFR) among the Chinese, Malays and Indians for both males and females. The predicted FEV1 and FVC values (specific age and height) for both sexes were highest among the Chinese followed by the Malays than Indians, in that order. Regression equations, with age and height as independent variables, were derived for males and females in each ethnic group to predict normal pulmonary function for the Singapore Chinese, Malay and Indian populations. The predicted values of various pulmonary function measurements obtained from these regression equations for subjects of specified age (30 years) and height (165 cm for men, 155 cm for women) were compared with those reported in other studies. Differences were observed among the different races.

Matched MeSH terms: Ethnic Groups*
Unperceived dental needs in a group of Malaysian elderly patients

Razak IA, Ali MM

Ann Acad Med Singap, 1989 Sep;18(5):516-8.
PMID: 2619242

The present study analysed the records of 342 elderly subjects aged 55 years and above of different ethnic groups to ascertain the types and level of their unperceived dental needs. The overall percentage of unperceived needs was highest among the Malays (96.1% or 74/77 subjects) and among the men (88.5% or 139/157 subjects). The unperceived need for prosthetic treatment was highest among the Malays and Chinese as well as among women, whereas the unperceived need for treatment for periodontal disease was highest among the Indians. The data for unperceived needs for prosthetic treatment as well as for treatment for caries and periodontal disease were somewhat similar among men. Within each ethnic group, variations among sex in the unperceived needs for the various dental symptoms were also noticeable. Further research is indicated to ascertain the role of traditional and cultural concepts and dogmas in determining the importance attached to the various dental health symptoms within each ethnic group.

Matched MeSH terms: Ethnic Groups*
A cross-sectional study on the dietary patterns of multiethnic Malaysian preschoolers and their sociodemographic determinants

Hasmuni Chew NH, Mohd Saat NZ, Wong JE, Lee ST, Singh-Povel CM, Khouw I, et al.

Nutr Bull, 2024 Sep;49(3):294-313.
PMID: 38845457 DOI: 10.1111/nbu.12683

Early childhood is a critical developmental stage where established dietary patterns can impact lifelong health outcomes. This study investigates dietary patterns and their relationships with sociodemographic factors among Malaysian preschoolers. A total of 643 preschoolers of Malay, Indian, Chinese and other ethnicities participating in South East Asian Nutrition Surveys (SEANUTS II) were included. Dietary intake was assessed using a single triple-pass 24-h dietary recall method. Dietary patterns were derived using principal component analysis and their association with sociodemographic factors was determined using complex sampling logistic regressions. Five dietary patterns were identified: "healthy eating," "wholegrains and starchy vegetables," "high salt and sugar," "Western food," and "sugary drinks and legumes". Having older siblings was inversely associated with a "healthy eating" pattern (adjusted OR: 0.54, 95% CI: 0.33-0.87). Malay ethnicity was associated with higher odds of adhering to the "high salt and sugar" pattern (adjusted OR: 4.12, 95% CI: 2.20-7.75). Meanwhile, children living in urban areas (adjusted OR: 1.76, 95% CI: 1.03-3.01), those from middle-income families (adjusted OR: 3.20, 95% CI: 1.38-7.40) and whose fathers were overweight (adjusted OR: 2.79, 95% CI: 1.58-4.94) showed a higher association with "Western food" pattern. Conversely, children whose mothers had overweight were less likely to adhere to the "Western food" pattern (adjusted OR: 0.50, 95% CI: 0.30-0.83). Older age was significantly associated with a greater likelihood of the "sugary drinks and legumes" pattern (adjusted OR: 3.99, 95% CI: 1.75-9.06). There was no significant association between "wholegrains and starchy vegetables" pattern with sociodemographic characteristics (all p > 0.05). These findings suggest that ethnicity, age, residence area, having older siblings, parental weight status and household income level are associated with dietary patterns among multiethnic preschoolers in Malaysia. Thus, these sociodemographic characteristics should be considered when designing targeted dietary strategies and interventions for preschoolers.

Matched MeSH terms: Ethnic Groups/statistics & numerical data
Prevalence and patterning of maxillary premolar accessory ridges (MxPARs) in several human populations

Mihailidis S, Scriven G, Khamis M, Townsend G

Am J Phys Anthropol, 2013 Sep;152(1):19-30.
PMID: 23913636 DOI: 10.1002/ajpa.22323

We present new data on the prevalence and patterning of the maxillary premolar accessory ridge (MxPAR), a common but understudied morphological dental trait that is expressed as a linear elevation extending from the buccal cusp ridge to the medial sulcus of maxillary premolar teeth. A total of 579 sets of dental casts, representing six ethnic groups, were scored using the five-grade system proposed by Burnett et al. (2010). The frequency and distribution of the MxPAR were determined by tooth type, sex, side, locus and ethnicity, and the applicability of the scoring system was assessed. The MxPAR was found in approximately two-thirds of premolar teeth, more often on second than first premolars, and more often on the distal aspect of the occlusal surface than the mesial. There was some evidence that more pronounced forms of the feature occurred more often in males than females, and that there may be some directionality in its expression between sides. Variation was also noted in the frequency of occurrence and degree of expression of the MxPAR between ethnic groups. Intra- and inter-observer concordance rates for scoring the MxPAR were low, confirming that it was difficult to score the trait identically on two different occasions. Our findings have clarified the distribution of the MxPAR within the dentition and between ethnic groups, and highlighted the need for researchers to carry out thorough replicability studies and to decide on an appropriate breakpoint for determining presence or absence of this feature before embarking on genetic studies or bio-distance analyses.

Matched MeSH terms: Ethnic Groups/statistics & numerical data
Physical work capacity and pulmonary function of Malaysian adolescent females

Duncan MT, Scammell CA

Hum Biol, 1977 Feb;49(1):31-40.
PMID: 844839
Matched MeSH terms: Ethnic Groups*
Intestinal parasitism among Penan children of the Upper Baram, Sarawak

Kan SP, Yap SB, Yap PL

Asia Pac J Public Health, 1987;1(1):38-41.
PMID: 3452378
Matched MeSH terms: Ethnic Groups*
Does ethnicity contribute to the control of cardiovascular risk factors among patients with type 2 diabetes?

Lee PY, Cheong AT, Zaiton A, Mastura I, Chew BH, Sazlina SG, et al.

Asia Pac J Public Health, 2013 Jul;25(4):316-25.
PMID: 22186400 DOI: 10.1177/1010539511430521

This study aimed to examine the control of cardiovascular risk factors among the ethnic groups with type 2 diabetes in Malaysia. The authors analyzed the data of 70 092 adults from the Malaysian diabetes registry database. Malays had the worst achievement of target for most of the risk factors. Indians had poor achievement of control for waist circumference (odds ratio [OR] = 0.6, 95% confidence interval [CI] = 0.6-0.7) and high-density lipoprotein cholesterol (OR = 0.5, 95% CI = 0.4-0.5). As compared with the Malays, the Chinese had a better achievement of target control for the risk factors, including the following: body mass index (OR = 1.3, 95% CI = 1.2-1.4), blood pressure (OR = 1.3, 95% CI = 1.3-1.4), total cholesterol (OR = 1.7, 95% CI = 1.6-1.8), low-density lipoprotein cholesterol (OR = 1.7, 95% CI = 1.6-1.8), glycated hemoglobin A1c (OR = 1.4, 95% CI = 1.3-1.4) and fasting blood glucose (OR = 1.4, 95% CI = 1.3-1.5). Ethnicity, sociocultural factors, and psychobehavioral factors should be addressed in designing and management strategies for the control of cardiovascular risk factors among type 2 diabetes patients.

Matched MeSH terms: Ethnic Groups/statistics & numerical data*
Longitudinal study of dental caries increment in Malaysian school children: a 5-year cohort study

Masood M, Yusof N, Hassan MI, Jaafar N

Asia Pac J Public Health, 2014 May;26(3):260-7.
PMID: 22218936 DOI: 10.1177/1010539511420704

The aim of this 5-year longitudinal cohort study was to assess the prevalence, severity, and trends in caries increment and impact of the School Dental Incremental Care Programme (SDICP). Data were gathered from school dental records as part of the SDICP. A sample of 1830 children were included and checked for caries experience annually using World Health Organization criteria. In total, 95.4% of the children were caries free in 2004, and caries experience declined to 70.5% in 2009 with an average of 4.9% annually. At baseline, the mean DMFT (confidence interval [CI]) was 0.06 (0.05-0.08) and increased to 0.58 (0.53-0.63) in 2009. Children with active caries were 4.4% in 2004, and figures rose to 9.6% in 2009. The FT component increased most rapidly during these 5 years from 0.2% to 25.1%. Overall caries prevalence and increment was low in this study. Proportions of FT component were higher as compared with DT component with low rate of extractions during the latter years of the study.

Matched MeSH terms: Ethnic Groups/statistics & numerical data
Distribution of cytokine gene polymorphisms in five Malay subethnic groups in Peninsular Malaysia

Norhalifah HK, Zafarina Z, Sundararajulu P, Norazmi MN, Edinur HA

Int J Immunogenet, 2015 Jun;42(3):200-3.
PMID: 25809422 DOI: 10.1111/iji.12189

In this survey, we have successfully genotyped 22 single nucleotide polymorphisms in the 13 cytokine genes for five Malay subethnic groups (Kelantan, Acheh, Mandailing, Minangkabau and Patani Malays) using polymerase chain reaction-sequence-specific primer cytokine genotyping kit (Invitrogen, Carlsbad, CA, USA). Most of the cytokine genes showed similar pattern of allelic spectra with wild-type alleles (e.g. ILIa-889/C, ILIB+3962/C and IL6 nt565/G) that represent more than 80% in the studied Malay subethnic groups. These newly observed cytokine alleles and subsequent analyses clearly indicate genetic contribution from Asia in the studied Malay subethnic groups with evidence of admixture from neighbouring populations in Patani Malays. The cytokine data sets for the five Malay subethnic groups deposited in this report can also be used as reference standard for searching suitable donor for allograft transplant and diseases association study. This is particularly relevance as our analyses showed differences between the Malay subethnic groups and other populations screened for cytokine genes.

Matched MeSH terms: Ethnic Groups/genetics*

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