Introduction: Intake of soy isoflavones has been shown to be beneficial in reducing
blood pressure, a known cardiovascular risk factor. This study investigated the
association between intake of soy isoflavones and blood pressure among multiethnic Malaysian adults. Methods: A total of 230 non-institutionalised Malaysians
aged 18-81 years were recruited through multi-stage random sampling from urban
and rural areas in four conveniently selected states. Participants were interviewed
on socio-demographics, medical history, smoking status, and physical activity.
Measurements of height, weight, waist circumference (WC), and blood pressure
(BP) were taken. Information on usual intake of soy foods was obtained using a
validated semi-quantitative food frequency questionnaire. Results: The mean
intake of soy protein of both urban (3.40g/day) and rural participants (3.01g/day)
were lower than the USFDA recommended intake level of soy protein (25.00g/day).
Urban participants had significantly higher intake of isoflavones (9.35±11.31mg/
day) compared to the rural participants (7.88±14.30mg/day). Mean BP levels were
significantly lower among urban (136/81mmHg) than rural adults (142/83mmHg).
After adjusting for age, gender, educational level, household income, smoking status,
physical activity, BMI and WC, soy protein intake was significantly associated with
both SBP (R2=0.205, β=-0.136) and DBP (R2=0.110, β=-0.104), whilst soy isoflavones
intake was significantly associated with SBP (β=-0.131). Intake of 1 mg of isoflavone
is estimated to lower SBP by 7.97 mmHg. Conclusion: Higher consumption of
isoflavones among the urban participants showed an association with lower levels
of SBP. Use of biological markers for estimating isoflavones levels is recommended
to investigate its protective effects on blood pressure.
Introduction: A retrospective study was conducted with the aim of determining
the factors that affect weight loss among post-bariatric surgery patients. Methods:
A successful weight loss outcome in this study was defined as achieving at
least 50% excess weight loss (EWL). Eligible participants were those who had
undergone bariatric surgery at least two years prior to the study. Adherence to
lifestyle recommendations post-bariatric surgery, binge eating, depression, and
social support were assessed. Results: A total of 51 post-bariatric surgery patients
were recruited with a mean post-operative period of 3.2±0.7 years. The mean preoperative weight of 116.6±28.8 kg and body mass index (BMI) 45.2±8.8 kg/m2 were
significantly reduced to 86.6±21.0 kg and 33.6±6.7 kg/m2, respectively, during
follow-up (p
Introduction: Sugar is widely consumed and excessive intake has been associated
with increased risk of weight gain, diabetes mellitus and cardiovascular diseases,
leading to metabolic syndrome (MetSyn). However, the association between sugar
intake and MetSyn has seldom been studied among multi-ethnic Malaysian older
adults.
Methods: A total of 1,057 respondents aged ≥60 years were recruited through
multistage random sampling from selected states. Anthropometric parameters, blood
pressure, blood test for sugar and lipid profile were determined. Dietary intake was
derived using a 7-day dietary history questionnaire (DHQ) and a semi-quantitative
food frequency questionnaire (FFQ) for added sugar intake.
Results: Prevalence of
MetSyn was 39.9%, 30.9% and 42.2% using the harmonised definition, International
Diabetes Federation (IDF) and National Cholesterol Education Program’s Adult
Treatment Panel III (NCEP-ATPIII) definitions respectively. Mean total sugar intake
was 40.5±32.0 g (8 tsp) and added sugar intake was 33.0±31.0 g (6 tsp). Excessive
added sugar consumption at 100th percentile increased risks of high total cholesterol
by two-fold (p
Introduction: Malnutrition among cancer patients is associated with a higher risk of
gastrointestinal toxicity which develops during treatment and may affect quality of life (QOL).
Thus, this cross-sectional study aimed to determine the nutritional status and QOL of 30
oncology patients (mean age 50.0+10.7 years) prior to pelvic radiotherapy at Hospital Sultan
Ismail, Johor Bahru.
Methods: Patients were assessed for anthropometry measurements,
24-h diet recall and nutritional status using Scored Patient-Generated Subjective Global
Assessment (PG-SGA) questionnaire while the European Organization for Research and
Treatment of Cancer Care Quality of Life Questionnaire (EORTC QLQ-C30) was used to
assess QOL two weeks prior to the initiation of pelvic radiotherapy.
Results: Mean Body
Mass Index (BMI) of patients was 23.3+3.3kg/m2
and 33% of patients experienced weight
loss prior to pelvic radiotherapy. The PG-SGA rating indicated that 63% of patients were at
Stage A (well-nourished) and 37% were in Stage B (moderate malnutrition). The PG-SGA
numerical score was a significant predictor of QOL, after adjusting for socio-demographic
factors (R2
=0.861, p
The relationship between anaemia and cognitive function was evaluated among 35 Chinese elderly (24 men and 11 women) aged 60 to 85 years (mean age 70.1 ± 6.7 years) from five old folks homes in Klang Valley. They were interviewed to obtain information on social and health status, habitual dietary intake and cognitive function. Hodkinson's Abbreviated Mental Test was used to measure the cognitive function. Haematological indices which included Full Blood Count (FBC), serum iron, serum ferritin, Total Iron Binding Capacity (TIBC), serum folate and serum cobalamine (vitamin B12) were measured using an automated analyzer. Anthropometric measurements and clinical signs of anaemia were also examined. The findings indicated that the prevalence of anaemia as assessed using haemoglobin alone was 22.9%, while iron deficiency anaemia based on low serum iron, microcytic and hypochromic criterion was detected among 5.7% of the sample. Subclinical folate and vitamin B12 deficiencies were diagnosed among 34.3% and 8.6% of the subjects. However, there was no occurrence of megaloblastic anaemia. There was a positive correlation between cognitive score with mid upper arm circumference (MUAC) (r=0.547, p
Kajian kes-kawalan ini dijalankan untuk mengkaji hubungan adipositi dan komposisi tubuh terhadap risiko kanser payudara di kalangan 70 orang wanita yang baru didiagnos kanser payudara dan 138 orang kawalan. Parameter antropometri yang merangkumi tinggi, berat, ukuran pinggang dan ukuran pinggul dan aras glukosa darah berpuasa serta tekanan darah diukur di kalangan subjek. Komposisi tubuh ditentukan menggunakan analisis bioimpedans (Maltron 906). Hasil kajian menunjukkan Indeks Jisim Tubuh (?T) kumpulan kes adalah 26.0 ± 4.8 kg/m2 dan 25.3 ± 4.5 kg/m2 bagi kumpulan kawalan (p > 0.05). Seramai 71% subjek dari kumpulan kes dan 40% subjek kumpulan kawalan mengalami obesiti abdominal (ukurlilit pinggang 80 cm) [OR = 3.4 (95% CI =1.7-6.9] (p < 0.05). Wanita pra menopaus berisiko sebanyak empat kali untuk mendapat kanser payudara dengan [Adjusted OR = 4.3 (95% CI = 1.8-10.3)]. Peratus lemak tubuh adalah tinggi di kalangan kes (36.4 ± 4.7%) berbanding kawalan 35.3 ± 4.4% tetapi perbezaan ini adalah tidak signifikan. Jisim Tubuh Tanpa Lemak ?TTL) menunjukkan nilai min 38.8 ± 5.7 kg bagi kawalan dan 38.9 ± 5.5 kg pada kes. Korelasi positif yang lemah ditunjukkan di antara umur dan IJT (r = 0.179, p = 0.010), ukuran pinggang (r = 0.218, p = 0.002), nisbah pinggang-pinggul (NPR) (r = 0.233, p = 0.001) dan peratus lemak tubuh (r = 0.330, p = 0.000). Kesimpulannya, obesiti abdominal meningkatkan risiko kanser payudara, terutama di kalangan wanita pra menopaus. Obesiti jenis ini dan peratus lemak tubuh adalah meningkat dengan pertambahan usia. Adalah penting bagi wanita untuk mengekalkan ukuran pinggang yang sihat melalui gaya hidup sihat bagi mengurangkan risiko kanser payudara.
To compare the ability of methods based on skeletal muscle index (SMI) and another one by the European Working Group
on Sarcopenia in Older People (EWGSOP) based on both muscle mass and physical function in identifying older adults
with sarcopenia. Anthropometric measurements and physical performance (hand grip strength and gait speed) were
performed. In order to determine the value of SMI, body impedance analysis was also carried out. A total of 426 older
adults, mostly women (60.8%) with mean age of 68.4 ± 6.2 years participated in this study. Methods based on SMI and
EWGSOP identified 50.5% and 32.2% older adults as sarcopenic respectively. Method based on SMI showed a significantly
higher percentage of men (70.7%) were sarcopenic as compared to women (37.5%) (p < 0.05). No such difference was
noted for EWGSOP method, with 28.7% of men were sarcopenic as compared to women (34.4%). Binary logistic regression
indicated that aged 75 years and above (adjusted odds ratio: 3.3, 95% confidence interval: 1.9 – 5.6) and having arthritis
(adjusted odds ratio: 2.5, confidence interval: 1.3 – 4.7) to be associated with sarcopenia as assessed using method
recommended by EWGSOP. The lower prevalence of sarcopenia by EWGSOP as compared to SMI may be due to the more
comprehensive method by EWGSOP. Further research regarding validation of these two screening methods against a gold
standard of screening for sarcopenia is needed in order to identify the best method..
The expansion of ageing population has gained much public attention on the importance of healthy and successful ageing,
which is absence of major chronic diseases, preserved physiological and cognitive functioning and active engagement
with life. Previous studies have found there was a significant correlation between physical fitness with cognition. However,
the relationship between physical fitness with successful and unsuccessful cognitive ageing groups are very limited. This
study was aimed to identify the significant physical fitness components that contribute in reducing risk of cognitive decline
represented as different cognitive ageing groups. A total of 300 community-based elderly aged 60 and above from the
states of Selangor, Perak and Kelantan were recruited using multistage random sampling method in this cross-sectional
study. Cognitive function of subjects was categorized into three groups, namely Mild Cognitive Impairment (MCI) (n
= 100), Usual Ageing (UA) (n = 100) and Successful Ageing (SA) (n = 100) based on defined criteria. Senior Fitness
Tests included 2-minute step, handgrip strength, chair stand, chair sit-and-reach, 8 foot up-and-go and back scratch
were measured to determine the cardiorespiratory fitness; muscle strength; agility and flexibility of subjects. SA group
had significantly better performance than non-SA groups in all fitness components, except for chair sit-and-reach. After
controlling for age, gender, education years and smoking status, handgrip strength and chair stand tests were associated
with a reduced risk of MCI by 7% [OR: 0.93, 95% C.I: 0.88-0.99, p < 0.05] and 15% [OR: 0.85, 95% C.I: 0.75-0.95, p <
0.01], respectively. These findings suggest that older adults with higher upper and lower body muscular strength could
serve as protective factors for cognitive impairment. Further research is warranted to evaluate the mechanism of physical
and cognitive decline such as Motoric Cognitive Risk Syndrome (MCR) in more detailed for the purpose for promoting
healthy and successful ageing.
Omega-3 polyunsaturated fatty acids (PUFAs) is crucial to prevent a wide range of chronic diseases from a global view point. However, no suitable dietary assessment tool is available for usage among Malaysian population. The present study aimed to evaluate the validity of interviewer-administered semi-quantitative Food Frequency Questionnaire (FFQ) for assessing the omega-3 PUFAs intake among the Malays and Chinese elderly individuals in Klang Valley, Malaysia. Thirty-seven elderly people (54.1% women and 45.9% men), aged 60 years and above, were recruited from a community setting. Omega-3 PUFAs intake for the past one month was assessed using a 45-food item FFQ and validated against 3 days Food Record (FR). Wilcoxon signed rank test indicated no significant mean intake difference between two assessment methods. Significant correlation was found for total omega-3 PUFAs (r=0.926), α-linolenic acid (ALA) (r=0.745), eicosapentaenoic acid (EPA) (r=0.579) and docosahexaenoic acid (DHA) (r=0.912). Bland-Altman analysis exhibited no apparent systematic bias between the two methods for total omega-3 PUFAs intake, while quartile analysis classified 73% subjects assigned into the same quartile. Conclusively, the newly-developed FFQ yielded a reasonable validity in the tested population and provided a convenient means to estimate omega-3 PUFAs intake within healthy Malays and Chinese elderly individuals. Further study to evaluate its validity and reproducibility for different age groups is required.
Excess added sugar consumption is related to poor health outcomes in older adults. The sugar content of local food is limited. However, this information is imperative for understanding potential risks from overconsumption of sugars among older adults. This study was carried out to determine the type and total sugar contents in 70 types of local desserts, snacks and cooked foods, using high performance liquid chromatography. The type of food chosen was based on the highly consumed food by the older adults in Malaysia. The samples were collected in triplicates from local restaurants or stalls located in Selangor, Perak and Johor, stored at -20°C and freeze dried prior to analysis. Results showed that average sugar in each 100 g of local desserts, snacks and cooked foods were 13.69 ± 5.94 g, 8.41 ± 6.15 g and 2.1 ± 1.87 g respectively. The highest sugar content per 100 g samples was found to be in sweet potato donut (kuih keria), mashed banana fritter (cekodok pisang) and noodles with sweet potato gravy (mee rebus). The lowest sugar content per 100 g samples was found to be baked glutinous rice (pulut panggang), vadai and noodle soup (mee sup). Meanwhile, the highest sugar content per standard portion was found to be noodles with sweet potato gravy (mee rebus), peanut pancake (kuih apam balik) and banana savoury (pengat pisang). Percentage of recovery for the sugar analysis was 95.2 ± 6.8%. The main type of sugar found in this analysed food samples was sucrose followed by maltose, glucose, fructose and lactose. Sucrose was the most common added sugars in local desserts, snacks and cooked foods of this study. However, compliance with low added sugar recommendations may not be achievable for the general public. Thus, these findings can be utilised in raising public awareness and assist in better estimation of sugar contents and intake.
There is some evidence stated that mood states might influence cognitive functioning, such as episodic memory, working memory and creative problem solving. This study was conducted to evaluate the relationship between mood states and cognitive functioning among older adults with Mild Cognitive Impairment (MCI). This study involved 12 male and 37 female subjects from Klang Valley aged 60 year old and above. MCI was defined based on criteria proposed by Peterson. Cognitive functions of the subjects were accessed using Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), Digit Span, Digit Symbol Substituition Test (DSST) and Visual Reproduction; while mood states including tension, depression, anger, vigour, esteem related affect, fatigue and confusion were accessed using Profile of Mood States (POMS) questionnaire. Total positive subscales score, total negative subscales score and total mood disturbance (TMD) were also calculated. There were significant positive correlations between tension (r = 0.325, p = 0.30), vigour (r = 0.235, p = 0.036), esteem related affect (r = 0.316, p = 0.034) and total positive subscales score (r = 0.307, p = 0.040) with verbal episodic memory as measured using RAVLT fifth trial. In addition, positive correlations were also observed between vigour (r = 0.228, p = 0.035) and total positive subscales score (r = 0.237, p = 0.025) with DSST. After adjusted for confounding factors, subjects who scored higher in esteem related affect (Adjusted OR = 0.390, 95% CI [0.069-0.711], p = 0.019) and tension (Adjusted OR = 0.253, 95% CI [0.075-0.431], p = 0.007) had better verbal episodic memory. Subjects who have higher total positive subscales score were also had faster processing speed (OR = 0.856, 95% CI [0.099-1.614], p = 0.028). However after adjusted for confounding factors, the relationship was not significant (Adjusted OR = 0.383, 95% CI [-0.247-1.013], p = 2.226). Older adults with MCI who had a more positive mood tend to have a better short-term verbal memory and faster processing speed.
Older adults who walk in their neighbourhood with greater street connectivity are reported to have lower limb physical performance decline. There is limited information regarding the association between built environment characteristics and physical performance in older adults. The aim of this study was to examine the association between built environment characteristics, physical performance, falls risk and functional mobility among older adults. Sixty four (27 men and 37 women) community dwelling older adults aged 60 years and above (mean 67.4 ± 7.1 years) from senior citizen clubs in Kuala Lumpur, Malaysia participated in this cross-sectional study. Built environment characteristics were assessed using an adapted Neighbourhood Environment Walkability Scale (NEWS). Physical performance and falls risk was measured using Short Physical Performance Battery (SPPB) and Profile Physiological Profile Assessment (PPA) respectively. Timed Up and Go (TUG) and gait speed tests were used to assess functional mobility. There was a significant correlation between built environment and physical performance (r = 0.43, p < 0.001) and functional mobility measured using gait speed test (r = 0.27, p < 0.05) among older adults. Built environment was identified as a significant determinant of physical performance (R2 = 0.19, p < 0.001). Built environment characteristics is an important external factor in preserving physical performance in older adults. Programmes and policies for a more favourable built environment characteristics in the neighbourhoods should be encouraged to promote and maintain physical performance among older adults.
Fruit and vegetable are the natural foods that contained various nutrients vital for good health and help in weight loss
by suppressing an individual’s appetite. Therefore, this review aimed to investigate the acute effect of fruit and vegetable
intake on satiety and energy intake. We included randomized controlled trial or experimental designs measuring fruit
and/or vegetable intake on satiety using subjective appetite rating and appetite related hormone and energy intake among
healthy adults, published in English-language. The use of extract, powder form or concentrated fruit and/or vegetable
and animal study were excluded. Twelve studies were identified from Pubmed, Science Direct and Cochrane from the
year 1995 to August 2017, consists of six studies on fruit and six studies on vegetable. This review discussed the preload
of fruit and vegetable in promoting satiety and reducing the energy intake. Manipulating energy density rather than
portion size was effective in reducing total energy intake and promotes satiety. Fruit and vegetable in solid form had a
greater satiety effect and significantly reduce energy intake compared to liquid or pureed form. The variation in time
interval between fruit and/or vegetable intake and the test meal may also account a significant effect on satiety up to 2
h and diminished 3 h onward. The satiety effect of fruit and vegetable would be beneficial in body weight management.
Ulam is fresh traditional Malaysian vegetables which normally consumed in raw form or after a short blanching process.It contains high antioxidants and polyphenols. However, there is limited study about the relationship between ulam consumption and cognitive status. Thus, a cross sectional study was conducted to determine the relation with cognitive function among 132 middle-aged Malays adults (45-59 years old), ecruited by convenient sampling from low income residences in Klang Valley. Respondents were interviewed to obtain data on sociodemography, dietary intake and total ulam intake and also measured for anthropometric parameters at respective community centres. Cognitive status was measured using Digit Span (attention and working memory), Rey auditory verbal learning test (RAVLT) (verbal memory) and comprehensive trail making test (CTMT) (cognitive flexibility). The average ulam intake by the respondents was 15.1 ± 8.2g/day and the top five highest consumed ulam were petai (68.1%), pucuk paku (62.9%), ulam raja (56.8%), pegaga (54.6%) and kesum (44.7%).There was a significant correlation between ulam intake with Digit Span (r = 0.265, p = 0.006), total immediate recall of RAVLT (r = 0.427, p < 0.001) and CTMT (r = 0.257, p = 0.007). Analysis of multiple regression indicated that total ulam intake was a significant predictor for Digit Span (R2 = 0.152, p < 0.05), RAVLT (R2 = 0.335, p = 0.001) and CTMT (R2 = 0.310, p < 0.001). In conclusion, this study showed that ulam has the potential to protect against cognitive decline, however, randomized control trials should be conducted to determine the efficacy of the ulam as neuroprotective agent.
Older adults quite often had an inadequate diet leading to micronutrient deficiencies and impaired immune response with subsequent development of degenerative diseases. This study aimed to determine the adequacy of energy and nutrient intake and its distribution among three aging groups i.e. successful aging (SA), usual aging (UA) and mild cognitive impairment (MCI). This is a cross-sectional study involving a large sample size (n = 2322) of older adults recruited through multistage random sampling from four states of Malaysia. An interview was conducted to measure dietary intake, neurocognitive status and functional status by using the Diet History Questionnaire (DHQ), Mini-Mental State Examination (MMSE), Rey Auditory Learning Test (RAVLT), Geriatric Depression Scale (GDS), Instrumental Activity of Daily Living (IADL) and Quality of Life Questionnaire. For comparison of dietary intake, a sub-sample of 173 respondents from each aging groups were matched and selected using a comparative cross-sectional approach. Women in SA group had the highest mean intake of vitamin A, calcium (p <0.05), vitamin C, riboflavin and iron (p<0.001). The same aging group also achieved the highest RNI percentage for the same nutrients. More than 80% of respondents for all aging groups did not met the recommended nutrient intake (RNI) for vitamin E, thiamin, niacin, folate, calcium and zinc. In women, MCI respondents were more likely to have an inadequate intake of vitamin A, C, riboflavin and iron followed by UA and SA. Inadequate vitamin E, niacin, folate and calcium were prevalent among all gender and aging groups. There is a need to further distinguish specific dietary patterns associated with these three aging groups to promote optimal nutrient intake for cognitive health.
This study was conducted to determine the content of macronutrients and sugar in 30 types of food selected from three
zones in Peninsular Malaysia. The food samples consisted of 14 types of processed foods and beverages, 8 types of
fruits and 10 types ready to eat food. Each type of food and drink were purchased from selected restaurants, stores and
supermarkets from three different zones which were North zone (Perak), Central zone (Selangor) and South Zone (Johor).
Methods used for proximate analysis were based on the standard methods of AOAC (1997) while the total carbohydrate
was calculated by difference method. Total calories were calculated using Atwater method. Total sugar content were
analysed using high performace liquid chromatography (HPLC). Dietary fibre contents were determined by using a
combination of enzyme-gravimetric methods (AOAC 985.29 and AACC 32-05). The results showed that peanut butter has
the highest value of fat (44.75 ± 7.59 g/100 g), total calorie (611 ± 38 kcal /100 g) and dietary fibre contents (8.07 ± 0.98
g/100 g). Highest protein content (21.98 ± 2.57 g/100 g) was found in low-fat milk powder. The highest carbohydrate
(97.48 ± 1.47 g/100 g) and total sugar (86.7 ± 2.9 g/100 g) contents were found in palm sugar. The results of this study
will update and add up to the data for the Malaysian Food Composition Table and can provide useful information in
choosing healthy foods based on the nutrient contents of the food.
This cross sectional study was conducted to determine the validity of three screening tools, Mini Nutritional Assessment Short Form (MNA-SF), Malnutrition Risk Screening Tool for Community (MRST-C) and Malnutrition Risk Screening Tool for Hospital (MRST-H) among elderly people at health clinics. The screening tools were validated against anthropometric and functional assessments. The anthropometric assessments that were carried out included body weight, height, arm span, body mass index (BMI), calf circumference (CC) and mid upper arm circumference (MUAC). A set of questionnaire on manual dexterity, muscular strength, instrumental activities daily living (IADL) and cognitive status was used to assess functional abilities. A total of 156 subjects were recruited from rural (38 subjects) and urban (118 subjects) health clinics at Sabak Bernam and Cheras respectively. Subjects' age ranged from 60 to 83 years old, with 44.2% were men and 55.8% women. The prevalence of muscle wasting among the subjects assessed from MUAC and CC were both 7.0%. MNA-SF had the highest correlation with BMI (r = 0.497, p<0.001), followed by MUAC (r = 0.398, p<0.001), CC (r = 0.473, p<0.001), cognitive assessment (r = 0.229, p<0.001) and handgrip strength (r = 0.209, p<0.001). Whilst MRST-C had the highest correlation with IADL score (r =-0.320, p<0.001) and MRST-H had the highest correlation with the lock and key test (r = -0.325, p<0.01). Sensitivity was the highest for MNA-SF (93.2%), followed by MRST-H (52.5%) and MRST-C (25.8%). Specificity was the highest for MRST-H (97.3%), followed by MRST-C (90.8%) and MNA-SF (79.4%). Positive predictive value (PPV) for MRST-H, MNA-SF and MRST-C was 55.5%, 18.2% and 14.1%, respectively. In conclusion, among the screening tools being validated, MNA-SF is considered the most appropriate tool to be used in health clinics for identification of elderly individuals who are at high risk of malnutrition.
Malnutrition is common among pediatric oncology patients. Factors contributing to malnutrition include physiological abnormalities, response to the tumors and side effects of the treatment. A pilot study was carried out to determine the nutritional status of 17 pediatric oncology patients aged 4 to 12 years old in Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur. The
nutritional status was assessed via anthropometric measurements and dietary intake through 3 days repeatitive 24 hours diet recall with subjects and their carers. Biochemical profiles (serum albumin and hemoglobin) were reviewed from the medical record. Through anthropometry measurements, weight and height were used to calculate Z-scores and further determine the percentile weight-for-age, height-for-age using NCHS percentile charts (WHO 1983). Frisancho’s standards (1981) were used to define malnutrition based on MUACfor- age. Underweight as determined using z scores below -2 for weight-for-age was observed in 70.6% of the subjects. Whilst, 76.5% of the subjects were classified as stunted (z score < –2) for height-for-age. Based on MUAC-for-age percentile, the sign of severe malnutrition category (<5 percentile) was observed in 35.3% of the subject and 23.6% of the subject were in the moderate malnutrition (>5 – <10 percentile). About 70.6% of the subject had low haemoglobin (< 11 g/dl) and 29.4% of the subject were hypoalbuminemia (< 35 g/dl) . Total macronutrient intake was assessed and compared with the individual requirement (Seashore 1984) for energy and protein intake were satisfactory, except for subjects in age group 10 – 12 years who achieved only 70% of the individuals requirements. As a conclusion, although food intake of the subjects was satisfactory but chronic malnutrition was prevalent. Early recognition of malnutrition is essential in order to plan for a nutritional intervention and further enhancing the quality of life.
Key words: Nutritional status, pediatric oncology, anthropometric, dietary intake, biochemical profile.
Relatively less comprehensive web based programme has been developed for detecting risk of mild cognitive impairment (MCI) and further impart preventive strategies and lifestyle education. Thus, this study has developed a comprehensive web based programme for early screening of risk of MCI together with education package for preventing MCI known as WESIHAT 2.0. WESIHAT 2.0 is a senior friendly website which has appropriate design interface facilitating access of older people especially with the use of touch-screen technology. WESIHAT 2.0 has incorporated four major components namely TUA WELLNESS screening tool, which is a comprehensive, online based, 10-item screening tool for detecting risk of MCI, 10-guides for preventing MCI, health diary and healthy food. Evaluation of acceptance of WESIHAT 2.0 was done among 71 people which comprised of 30 older people and 30 caregivers, chosen equally based on ethnic composition and 11 health care professionals who has experience working in the field of geriatric and 2 freelance website developer. All older people and caregivers stated that the content of website was very useful for preventing MCI, however, about 36.4% of health professionals stated several improvements needed to be done before releasing the end-product to the users. Comments given were smaller font size (27.3), addition of more pictures (27.3%), using simpler terms (36.4%) and changing certain design for better view of older people (18.2%). Amendments were made based on each comment given and the finalized website were used for a 6-month intervention programme for neuroprotection among older people who failed to achieve successful aging. It is timely for an online based approach for prevention of MCI. WESIHAT 2.0 is the first website in Malaysia which has been accepted by all older people and caregiver and more than half of healthcare professionals to prevent memory decline.
Polygonum minus is a plant rich in flavonoids and antioxidants beneficial for reducing oxidative stress and lipid peroxidation in neuronal membranes. This randomized, double-blind, placebo-controlled study evaluated the potential benefits of P. minus extract (LineMinusTM) towards improving cognitive function, mood status and quality of life. Thirty five middle-aged women (35-55 years old) were randomized into intervention (n=17) and control group (n=18). Two capsules of P. minus (250 mg) or placebo (100 mg maltodextrin) each were taken once daily for six weeks. Cognitive tests, mood and anthropometric measurements were measured at baseline, week 3 and week 6, whilst biomarkers were measured at baseline and week 6. Parameters related to mood and quality of life including energy/fatigue, social functioning and general health significantly improved from baseline to week 6 in the intervention group (p<0.05). Mean score for cognitive tests (i.e. digit span, comprehensive trail making test (CTMT) and three domains of CNS vital sign (CNSVS)] improved significantly in both intervention and control groups (p<0.05). There was a significant decrease of mean uric acid, estimated glomerular filtration rate (eGFR), total cholesterol and glycated hemoglobin (HbA1C) in the intervention group from baseline to week 6. P. minus supplementation has the potential to improve mood and quality of life and no adverse effects were reported by the participants after 6 weeks supplementation.