The chemical reactions of dry-disposed ash dump, ingressed oxygen, carbon dioxide, and infiltrating rainwater affect mineralogical transformation, redistribution, and migration of chemical species. Composite samples of weathered coal fly ash taken at various depths and fresh coal fly ash were examined using organic petrographic, X-ray diffraction, X-ray fluorescence techniques, and successive extraction procedures. Results obtained show relative enrichment of glass, Al-Fe-oxides, calcite, and tridymite in the weathered CFA, but the fresh CFA is enriched in mullite, inertinite, maghemite, and ettringite. The enrichment of the weathered CFA in amorphous glass suggests higher reactivity when compared to fresh CFA. The evident depletion of soluble oxides in the weathered CFA is attributed to flushing of the soluble salts by percolating rainwater. Comparative enrichment of examined elements in water-soluble, exchangeable, reducible, and residual fractions of the weathered CFA is partly due to the slow release of adsorbed chemical species from the alumina-silicate matrix and diffusion from the deeper sections of the particles of coal fly ash. Sodium and potassium show enrichment in the oxidisable fraction of fresh CFA. The estimated mobility factor indicates mobility for Ca, Mg, Na, Se, Mo, and Sb and K, Sr, V, Cu, Cr, Se, and B in fresh and weathered CFAs, respectively.
Multiple interactions of geogenic and anthropogenic activities can trigger groundwater pollution in the tropical savanna watershed. These interactions and resultant contamination have been studied using applied geochemical modeling, conventional hydrochemical plots, and multivariate geochemometric methods, and the results are presented in this paper. The high alkalinity values recorded for the studied groundwater samples might emanate from the leaching of carbonate soil derived from limestone coupled with low rainfall and high temperature in the area. The principal component analysis (PCA) unveils three components with an eigenvalue > 1 and a total dataset variance of 67.37%; this implies that the temporary hardness of the groundwater and water-rock interaction with evaporite minerals (gypsum, halite, calcite, and trona) is the dominant factor affecting groundwater geochemistry. Likewise, the PCA revealed anthropogenic contamination by discharging [Formula: see text] [Formula: see text][Formula: see text] and [Formula: see text] from agricultural activities and probable sewage leakages. Hierarchical cluster analysis (HCA) also revealed three clusters; cluster I reflects the dissolution of gypsum and halite with a high elevated load of [Formula: see text] released by anthropogenic activities. However, cluster II exhibited high [Formula: see text] and [Formula: see text] loading in the groundwater from weathering of bicarbonate and sylvite minerals. Sulfate ([Formula: see text]) dominated cluster III mineralogy resulting from weathering of anhydrite. The three clusters in the Maiganga watershed indicated anhydrite, gypsum, and halite undersaturation. These results suggest that combined anthropogenic and natural processes in the study area are linked with saturation indexes that regulate the modification of groundwater quality.
Mining activities have often been associated with the issues of waste generation, while mining is considered a carbon-intensive industry that contributes to the increasing carbon dioxide emission to the atmosphere. This study attempts to evaluate the potential of reusing mining waste as feedstock material for carbon dioxide sequestration through mineral carbonation. Characterization of mining waste was performed for limestone, gold and iron mine waste, which includes physical, mineralogical, chemical and morphological analyses that determine its potential for carbon sequestration. The samples were characterized as having alkaline pH (7.1-8.3) and contain fine particles, which are important to facilitate precipitation of divalent cations. High amount of cations (CaO, MgO and Fe2O3) was found in limestone and iron mine waste, i.e., total of 79.55% and 71.31%, respectively, that are essential for carbonation process. Potential Ca/Mg/Fe silicates, oxides and carbonates have been identified, which was confirmed by the microstructure analysis. The limestone waste composed majorly of CaO (75.83%), which was mainly originated from calcite and akermanite minerals. The iron mine waste consisted of Fe2O3 (56.60%), mainly from magnetite and hematite, and CaO (10.74%) which was derived from anorthite, wollastonite and diopside. The gold mine waste was attributed to a lower cation content (total of 7.71%), associated mainly with mineral illite and chlorite-serpentine. The average capacity for carbon sequestration was between 7.73 and79.55%, which corresponds to 383.41 g, 94.85 g and 4.72 g CO2 that were potentially sequestered per kg of limestone, iron and gold mine waste, respectively. Therefore, it has been learned that the mine waste might be utilized as feedstock for mineral carbonation due to the availability of reactive silicate/oxide/carbonate minerals. Utilization of mine waste would be beneficial in light of waste restoration in most mining sites while tackling the issues of CO2 emission in mitigating the global climate change.
Jurong Formation underlies part of Southern Johor Bahru which comprises well cemented and consolidated volcanic-sedimentary rocks. The study aims to assess quality and hydrogeochemistry of rock aquifer in Jurong Formation at Southern Johor Bahru which is mainly overlain by rhyolitic tuff. It also evaluates the differences in quality and hydrogeochemistry of rhyolitic tuff aquifer found in source and floodplain zones of South-West Johor Rivers Basin. In this study, a total of nine samples from four wells, namely TW1-TW4, were collected at foothills of Gunung Pulai (TW1) and Iskandar Puteri (TW2-TW4) in Southern Johor Bahru. The samples were examined for physiochemical parameters. The groundwater in the study area is fresh and non-saline with hardness of soft to hard. The pH of groundwater in source zone is significantly higher than in floodplain zone. Meanwhile, the hardness of groundwater in source zone is significantly lower than in other deep wells in floodplain zone as more calcite mineral is present. The concentration of manganese, iron and zinc is lower at source zone than floodplain zone. Three facies of water types were encountered during the study such as CaNaHCO3 in TW2, CaHCO3 in TW1 and TW3 and CaCl2 in TW4. The deep wells in floodplain zone are susceptible to saline intrusion. Finally, the groundwater quality in the study area is found to control by rock weathering especially silicates and carbonates, rainfall and proximity to seawater. This suggests the major control on groundwater chemistry is due to leaching of volcanic rocks and dissolution on calcite infillings. In conclusion, the groundwater is clean and safe in general although pH value is slightly acidic closer to straits and magnesium's presence in higher concentration at TW2.
Recently, the use of accelerated carbonation curing has attracted wide attention as a promising method to reduce carbon dioxide (CO2) emission and improve the mechanical properties of cement-based materials. However, the diffusion mechanism of CO2 in the matrix and the content of hydration products are the key factors that restrict the carbonation reaction rate. To understand the combined behavior of hydration and carbonation reactions, this paper investigates the influence of cement hydration induced by water-to-cement ratio (w/c) (ranging from 0.25 to 0.45) on microstructure and microhardness properties of cement paste. The experimental results demonstrated that carbonation only occurred at the surface layer of cement paste samples and carbonation efficiency was significantly influenced by greater hydration due to higher w/c. The carbonation depth of the sample with 0.45 w/c was about 6 times higher than that of sample with 0.25 w/c after 28 days of CO2 curing. XRD results revealed that calcite-type calcium carbonate is the main carbonation product and consumption of clinker phases (C2S and C3S) during the hydration enhanced the calcite precipitation in the pores of the surface layer. According to FTIR, with increasing w/c, the position of Si-O-Si stretching bond of the carbonated surface changed from Q2 to Q3, confirming the formation of amorphous silica-rich gel, along with the appearance of CO32- bonds related to calcite. In overall, the micro-mechanical analysis in this study showed that the carbonation significantly improved the surface microhardness of cement paste samples, while the refinement of capillary pores due to carbonation also decreased the negative impact of large pores formed in the matrix of cement paste prepared with high w/c.
The Damoh district, which is located in the central India and characterized by limestone, shales, and sandstone compact rock. The district has been facing groundwater development challenges and problems for several decades. To facilitate groundwater management, it is crucial to monitoring and planning based on geology, slope, relief, land use, geomorphology, and the types of the basaltic aquifer in the drought-groundwater deficit area. Moreover, the majority of farmers in the area are heavily dependent on groundwater for their crops. Therefore, delineation of groundwater potential zones (GPZ) is essential, which is defined based on various thematic layers, including geology, geomorphology, slope, aspect, drainage density, lineament density, topographic wetness index (TWI), topographic ruggedness index (TRI), and land use/land cover (LULC). The processing and analysis of this information were carried out using Geographic Information System (GIS) and Analytic Hierarchy Process (AHP) methods. The validity of the results was trained and tested using Receiver Operating Characteristic (ROC) curves, which showed training and testing accuracies of 0.713 and 0.701, respectively. The GPZ map was classified into five classes such as very high, high, moderate, low, and very low. The study revealed that approximately 45% of the area falls under the moderate GPZ, while only 30% of the region is classified as having a high GPZ. The area receives high rainfall but has very high surface runoff due to no proper developed soil and lack of water conservation structures. Every summer season show a declined groundwater level. In this context, results of study area are useful to maintain the groundwater under climate change and summer season. The GPZ map plays an important role in implementing artificial recharge structures (ARS), such as percolation ponds, tube wells, bore wells, cement nala bunds (CNBs), continuous contour trenching (CCTs), and others for development of ground level. This study is significant for developing sustainable groundwater management policies in semi-arid regions, that are experiencing climate change. Proper groundwater potential mapping and watershed development policies can help mitigate the effects of drought, climate change, and water scarcity, while preserving the ecosystem in the Limestone, Shales, and Sandstone compact rock region. The results of this study are essential for farmers, regional planners, policy-makers, climate change experts, and local governments, enabling them to understand the groundwater development possibilities in the study area.
This work presents the structural and adsorption properties of the CaCO3(-)-rich Corbicula fluminea shell as a natural and economic adsorbent to remove Cd ions from aqueous solutions under batch studies. Experiments were conducted with different contact times, various initial concentrations, initial solution pH and serial biosorbent dosage to examine the dynamic characterization of the adsorption and its influence on Cd uptake capacity. The characterization of the C. fluminea shell using SEM/EDX revealed that the adsorbent surface is mostly impregnated by small particles of potentially calcium salts. The dominant Cd adsorption mechanism is strongly pH and concentration dependent. A maximum Cd removal efficiency of 96.20% was obtained at pH 7 while the optimum adsorbent dosage was observed as 5 g/L. The Langmuir isotherm was discovered to be more suitable to represent the experimental equilibrium isotherm results with higher correlation coefficients (R(2) > 0.98) than Freundlich (R(2)
Mining waste that is rich in iron-, calcium- and magnesium-bearing minerals can be a potential feedstock for sequestering CO2 by mineral carbonation. This study highlights the utilization of iron ore mining waste in sequestering CO2 under low-reaction condition of a mineral carbonation process. Alkaline iron mining waste was used as feedstock for aqueous mineral carbonation and was subjected to mineralogical, chemical, and thermal analyses. A carbonation experiment was performed at ambient CO2 pressure, temperature of 80 °C at 1-h exposure time under the influence of pH (8-12) and particle size (
This study investigated the potential use of microalgae as partial cement replacement to heal cracks in cement mortar. Microbially induced calcite (CaCO3) precipitation (MICP) from Arthrospira platensis (A. platensis) (UMACC162) was utilised for crack-healing applications. Microalgae was cultivated in Kosaric Media (KM) together with filtered cement water (FCW), and used as a cement replacement material. The microalgal species was further evaluated for its capacity and adaptability towards large-scale culturing. The results showed that A. platensis could adapt and survive in cement water solution and cement mortar, suggesting the potential for self-healing in cement mortar. Further, the cultured species grown in both conditions (KM and KM & FCW) were harvested and incorporated into the cement mortar as a partial cement replacement material at different levels of 5%, 10%, 20%, and 30% of cement weight. The cement mortars partially replaced with microalgae were cured in water for 28 days. Pre-cracks were induced in the cured mortar with the 75% of their ultimate load. It took just 14 days for the microalgae-incorporated mortar to heal the cracks. The specimens with microalgae cultured in FCW showed a better performance and recovered 59% of their strength, with a maximum healed crack width of 0.7 mm. In terms of water tightness and porosity, they are comparable to the control mortar. The compressive strength measurements indicated the formation of calcite aggregate (crystal) that sealed the surface cracks, which was confirmed by a microstructural analysis. The results also demonstrate that the incorporation of microalgae into cement produced a self-healing effect, providing a new direction for crack healing. Additionally, the investigation indicated that replacing cement with microalgae reduced CO2 emissions by as much as 30%, with a substitution of 30% of microalgae. Exploring microalgae as a cement replacement could reduce carbon emissions and improve the state of the environment.
Passive bioremediation of metal- and sulfate-containing acid mine drainage (AMD) has been investigated in a batch study. Multiple substrates were used in the AMD remediation using spent mushroom compost (SMC), limestone, activated sludge (AS), and woodchips (WC) under anoxic conditions suitable for bacterial sulfate reduction (BSR). Limestones used were of crushed limestone (CLS) and uncrushed limestone, provided at two different ratios in mixed substrates treatment and varied by the proportion of SMC and limestone. The SMC greatly assisted the removals of sulfate and metals and also acted as an essential carbon source for BSR. The mixed substrate composed of 40% CLS, 30% SMC, 20% AS, and 10% WC was found to be effective for metal removal. Mn, Cu, Pb, and Zn were greatly removed (89-100%) in the mixed substrates treatment, while Fe was only removed at 65%. Mn was found to be removed at a greatly higher rate than Fe, suggesting important Mn adsorption onto organic materials, that is, greater sorption affinity to the SMC. Complementary with multiple treatment media was the main mechanism assisting the AMD treatment through microbial metal reduction reactions.
The potential of selected materials in treating metal-rich acid mine drainage (AMD) has been investigated in a series of batch experiment. The efficiencies of both single and mixed substrates under two conditions i.e. low- and high-concentration solutions containing heavy metals were evaluated. Synthetic metal-containing AMD was used in the experiments treated using spent mushroom compost (SMC), ochre, steel slag (SS), and limestone. Different ratios of treatment materials were incorporated in the substrate mix and were tested in an anoxic condition. In the batch test, physicochemical parameters (pH, redox potential, total dissolved solids, conductivity, and Ca concentration) and heavy metals (Fe, Mn, Pb, Zn, and Al) were analysed. The mixed substrates have shown satisfactory performance in increasing pH with increasing Ca concentration and removing metals. It has been found that SS and ochre played an important role in the treatment of AMD. The results showed that the mixed substrates SM1 (i.e. 10% SMC mixed with 20% ochre, 30% steel slag, and 40% limestone) and SM2 (i.e. 20% SMC mixed with 30% ochre, 40% steel slag, and 10% limestone) were effective in increasing the pH from as low as 3.5-8.09, and removing heavy metals with more than 90% removal efficiencies.
In this study, potassium oxide supported on dolomite adsorbent was used as an adsorbent for free fatty acids (FFAs) treatment in crude palm oil (CPO). The characteristics of the adsorbent were determined by TGA, XRD, SEM, BET and TPD-CO2. Taguchi method was utilized for experimental design and optimum condition determination. There were four parameters and three levels involved in this study: time (30, 60, 90 min), stirring rate (300, 500, 700 rpm), adsorbent dosage (1, 3, 5 wt%) and K2O concentration (5, 10, 15 wt%). The adsorbent had a larger pore size, higher basic strength, and more basic sites in greater efficiency (63%) in FFAs removal from CPO. The optimum conditions were at 30 min time, 700 rpm stirring rate, 5 wt% adsorbent dosage and 15 wt% K2O concentration. Taguchi method simplified determination of experimental parameters and minimized the operating costs.
The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle (OTC-CNP) after a single dose of intraperitoneal (IP) administration in BALB/c mice. A total of 100 female BALB/c mice divided into two groups of equal number (n = 50) were administered with 10 mg/kg OTC and OTC-CNP, respectively. Blood samples were collected before and post-administration from both groups at time 0, 5, 10, 15, and 30 min and 1, 2, 6, 24, and 48 h, and OTC plasma concentration was quantified using a validated HPLC-UV method. The pharmacokinetic parameters were analyzed using a non-compartment model. The Cmax values of OTC in OTC-CNP and free OTC treated group were 64.99 and 23.53 μg/ml, respectively. OTC was detected up to 24 h in the OTC-CNP group as against 1 h in the free OTC group following intraperitoneal administration. In the OTC-CNP group, the plasma elimination rate of OTC was slower while the half-life, the area under the curve, and the volume of the distribution were increased. In conclusion, the pharmacokinetic profile of OTC in the OTC-CNP group differs significantly from that of free OTC. However, further studies are necessary to determine the antibacterial efficacy of OTC-CNP for the treatment of bacterial diseases.
Multi-year instrumental records for input, throughflow and output waters of the Lilburn Cave system provide control on denudation rates as they respond to seasonal and spatial variability. Data suggest that maximum denudation is in the late fall and early winter. This is when non-snowmelt discharge is at its maximum. At lower discharge rates the volume of water moving through the cave system is the limiting control on the volume of denudation. During periods of snowmelt the limiting control is the rate at which the calcite dissolves. This is probably the result of water flowing through wider channels during these times. Based on instrumental measurements, there is considerable variation in terms of where denudation occurs inside the cave. The loci of dissolution change from year to year. This is to be expected in the dynamic environment of the cave where materials shift routinely. This variability should be studied over longer periods of time in order to more fully understand its extent. The relatively small area of carbonate exposure relative to the area of the drainage basin gives rise to relatively high denudation rates. The carbonate is being removed at a rate of about 5000 metric tons per year, or at about 830 mm/y. This is about five times the rate reported in the humid karst regions of Malaysia. This information indicates that the relative proportion of carbonate in the drainage basin needs to be considered when trying to estimate denudation in other areas.
Cockle shell-derived calcium carbonate nanoparticles have shown promising potentials as slow drug-releasing compounds in cancer chemotherapy. In this study, we evaluated the in vitro efficacy of docetaxel (DTX)-loaded CaCO3NP on 4T1 cell line. This was achieved by evaluating the following: cytotoxicity using MTT assay, fluorescence imaging, apoptosis with Annexin V assay, cell cycle analysis, scanning (SEM) and transmission electron microscopy (TEM), and scratch assay. Based on the results, DTX-CaCO3NP with a DTX concentration of 0.5 μg/mL and above had comparable cytotoxic effects with free DTX at 24 h, while all concentrations had similar cytotoxic effect on 4T1 cells at 48 and 72 h. Fluorescence and apoptosis assay showed a higher (p
A study was carried out to optimize the deacidification process for noni (Morinda citrifolia L.) extract using packed column of calcium carbonate. The experiments were based on a 3-level factorial design to study the optimum process of deacidification for M. citrifolia extract. The M. citrifolia extract was treated with CaCO3 packed in different column diameter (20, 25 and 30 mm), height of calcium carbonate (0, 0.5 and 1 cm) and feed rate (10, 30 and 50 ml/min). Physico-chemical characteristics which include pH, titratable acidity, turbidity, total polyphenol content and total soluble solids were measured. Results showed that only pH, titratable acidity and turbidity could be well represented using statistical models. For pH, only the effect of height of CaCO3 was found to be significant. While for titratable acidity and turbidity, effects of diameter column and height of CaCO3 were significant. The optimum conditions for the deacidification of M. citrifolia extract was by using a column diameter of 30 mm, CaCO3 height of 1 cm, and a feed rate of 50 ml/min.
The second most predominant cancer in the world and the first among women is breast cancer. We aimed to study the protein abundance profiles induced by lectin purified from the Agaricus bisporus mushroom (ABL) and conjugated with CaCO3NPs in the MCF-7 breast cancer cell line. Two-dimensional electrophoresis (2-DE) and orbitrap mass spectrometry techniques were used to reveal the protein abundance pattern induced by lectin. Flow cytometric analysis showed the accumulation of ABL-CaCO3NPs treated cells in the G1 phase than the positive control. Thirteen proteins were found different in their abundance in breast cancer cells after 24 h exposure to lectin conjugated with CaCO3NPs. Most of the identified proteins were showing a low abundance in ABL-CaCO3NPs treated cells in comparison to the positive and negative controls, including V-set and immunoglobulin domain, serum albumin, actin cytoplasmic 1, triosephosphate isomerase, tropomyosin alpha-4 chain, and endoplasmic reticulum chaperone BiP. Hornerin, tropomyosin alpha-1 chain, annexin A2, and protein disulfide-isomerase were up-regulated in comparison to the positive. Bioinformatic analyses revealed the regulation changes of these proteins mainly affected the pathways of 'Bcl-2-associated athanogene 2 signalling pathway', 'Unfolded protein response', 'Caveolar-mediated endocytosis signalling', 'Clathrin-mediated endocytosis signalling', 'Calcium signalling' and 'Sucrose degradation V', which are associated with breast cancer. We concluded that lectin altered the abundance in molecular chaperones/heat shock proteins, cytoskeletal, and metabolic proteins. Additionally, lectin induced a low abundance of MCF-7 cancer cell proteins in comparison to the positive and negative controls, including; V-set and immunoglobulin domain, serum albumin, actin cytoplasmic 1, triosephosphate isomerase, tropomyosin alpha-4 chain, and endoplasmic reticulum chaperone BiP.
This study investigates the effects of calcium carbonate (CaCO(3)) nanoparticles on the mechanical and thermal properties and surface morphology of polycaprolactone (PCL)/chitosan nanocomposites. The nanocomposites of PCL/chitosan/CaCO(3) were prepared using a melt blending technique. Transmission electron microscopy (TEM) results indicate the average size of nanoparticles to be approximately 62 nm. Tensile measurement results show an increase in the tensile modulus with CaCO(3) nanoparticle loading. Tensile strength and elongation at break show gradual improvement with the addition of up to 1 wt% of nano-sized CaCO(3). Decreasing performance of these properties is observed for loading of more than 1 wt% of nano-sized CaCO(3). The thermal stability was best enhanced at 1 wt% of CaCO(3) nanoparticle loading. The fractured surface morphology of the PCL/chitosan blend becomes more stretched and homogeneous in PCL/chitosan/CaCO(3) nanocomposite. TEM micrograph displays good dispersion of CaCO(3) at lower nanoparticle loading within the matrix.
Cancer stem cells CSCs (tumour-initiating cells) are responsible for cancer metastasis and recurrence associated with resistance to conventional chemotherapy. This study generated MBA MD231 3D cancer stem cells enriched spheroids in serum-free conditions and evaluated the influence of combined doxorubicin/thymoquinone-loaded cockle-shell-derived aragonite calcium carbonate nanoparticles. Single loaded drugs and free drugs were also evaluated. WST assay, sphere forming assay, ALDH activity analysis, Surface marker of CD44 and CD24 expression, apoptosis with Annexin V-PI kit, cell cycle analysis, morphological changes using a phase contrast light microscope, scanning electron microscopy, invasion assay and migration assay were carried out; The combination therapy showed enhanced apoptosis, reduction in ALDH activity and expression of CD44 and CD24 surface maker, reduction in cellular migration and invasion, inhibition of 3D sphere formation when compared to the free drugs and the single drug-loaded nanoparticle. Scanning electron microscopy showed poor spheroid formation, cell membrane blebbing, presence of cell shrinkage, distortion in the spheroid architecture; and the results from this study showed that combined drug-loaded cockle-shell-derived aragonite calcium carbonate nanoparticles can efficiently destroy the breast CSCs compared to single drug-loaded nanoparticle and a simple mixture of doxorubicin and thymoquinone.
Purpose: Modified top-down procedure was successfully employed in the synthesis of aragonite nanoparticles (NPs) from cheaply available natural seawater cockle shells. This was with the aim of developing a pH-sensitive nano-carrier for effective delivery of doxorubicin (DOX) on MCF-7 breast cancer cell line. Methods: The shells were cleaned with banana pelts, ground using a mortar and pestle, and stirred vigorously on a rotary pulverizing blending machine in dodecyl dimethyl betane solution. This simple procedure avoids the use of stringent temperatures and unsafe chemicals associated with NP production. The synthesized NPs were loaded with DOX to form DOX-NPs. The free and DOX-loaded NPs were characterized for physicochemical properties using field emission scanning electron microscopy, transmission electron microscopy, zeta potential analysis, Fourier transform infrared spectroscopy, and X-ray diffraction. The release profile, cytotoxicity, and cell uptake were evaluated. Results: NPs had an average diameter of 35.50 nm, 19.3% loading content, 97% encapsulation efficiency, and a surface potential and intensity of 19.1±3.9 mV and 100%, respectively. A slow and sustained pH-specific controlled discharge profile of DOX from DOX-NPs was observed, clearly showing apoptosis/necrosis induced by DOX-NPs through endocytosis. The DOX-NPs had IC50 values 1.829, 0.902, and 1.0377 µg/mL at 24, 48, and 72 hrs, while those of DOX alone were 0.475, 0.2483, and 0.0723 µg/mL, respectively. However, even at higher concentration, no apparent toxicity was observed with the NPs, revealing their compatibility with MCF-7 cells with a viability of 92%. Conclusions: The modified method of NPs synthesis suggests the tremendous potential of the NPs as pH-sensitive nano-carriers in cancer management because of their pH targeting ability toward cancerous cells.