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Displaying publications 21 - 25 of 25 in total

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Effects of sublethal concentrations of dieldrin on Culex pipiens fatigans

Thomas V

Med J Malaysia, 1973 Mar;27(3):225-30.
PMID: 4268931
Matched MeSH terms: Drug Tolerance
Selection of larvae of a laboratory colony of Culex pipiens fatigans Wiedemann for DDT-resistance

Thomas V

Med J Malaya, 1966 Mar;20(3):221-9.
PMID: 4380080
Matched MeSH terms: Drug Tolerance*
Fulltext The Effect of Tropical Environment on Fatigue Failure in Royal Malaysian Airforce (RMAF) Aircraft Structure and Operational Readiness

Venugopal A, Mohammad R, Koslan MFS, Sayd Bakar SR, Ali A

Materials (Basel), 2021 May 06;14(9).
PMID: 34066461 DOI: 10.3390/ma14092414

The environmental condition in which the Royal Malaysian Airforce is currently operating its aircraft is prone to corrosion. This is due to the high relative humidity and temperature. With most of its aircraft being in the legacy aircraft era, the aircraft's main construction consists of the aluminium 2024 material. However, this material is prone to corrosion, thus reducing fatigue life and leading to fatigue failure. Using the concept of either Safe Life or Damage Tolerance as its fatigue design philosophy, the RMAF adopts the Aircraft Structure Integrity Program (ASIP) to monitor its structural integrity. With the current problem of not having the structural limitation on corrosion-damaged structure, the RMAF has embarked on its fatigue testing method. Finite Element (FE) studies and flight tests were conducted, and the outcome is summarized. The conclusion is that the longeron tested on the aircraft can withstand the operational load, and its yield strength is below the ultimate yield strength of the material. These research outcomes will also enhance the ASIP for other aircraft platforms in the RMAF fleet for its structure life assessment or service life extension program.

Matched MeSH terms: Drug Tolerance
Fulltext Analysis of a low refractive index grating waveguide polarisation splitter based on resonant tunnelling

Yusoff, M.H.M., Hassan, H.A., Hashim, M.R., Abd-Rahman, M.K.

ASM Science Journal, 2008;2(2):139-148.
MyJurnal

The fabrication tolerance of a short and compact low refractive index grating waveguide polarisation splitter based on the principle of resonant tunnelling was analyzed in this study. The design utilised two grating waveguides with an intermediate conventional waveguide layer. The design and optimisation were conducted using the quasi 2-D effective index solver with global search algorithm. An optimum device operating at 1.55 μm wavelength was obtained at a length of 340 μm. The splitting ratios were calculated to be 36 dB and 15 dB, and the overall device transmission efficiencies, after considering the three-dimensional waveguide leakage loss, were estimated at 88% and 83% for tranverse magnetic and tranverse electric polarisation, respectively.

Matched MeSH terms: Drug Tolerance
Fulltext Comparison of Pain Tolerance between Opioid Dependent Patients on Methadone Maintenance Therapy (MMT) and Opioid Naive Individuals

Zahari Z, Lee CS, Ibrahim MA, Musa N, Mohd Yasin MA, Lee YY, et al.

J Pharm Pharm Sci, 2016;19(1):127-36.
PMID: 27096697 DOI: 10.18433/J3NS49

PURPOSE: This study compared pain sensitivity among opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive subjects.
METHODS: The three hundred participants comprised 152 opioid naive subjects and 148 opioid dependent patients. Opioid naive subjects had not taken any opioids including morphine and methadone to their best knowledge and were presumed so after two consecutive negative urine screenings for drugs. All opioid dependent patients were stabilized in treatment, defined as having been enrolled in the program for more than one month with no change of methadone dosage over the past one month. Excluded from the study were individuals with chronic or ongoing acute pain and individuals with a history of analgesics ingestion within 3 d before the cold pressor test (CPT). Pain tolerance to CPT was evaluated at 0 h, and at 2, 4, 8, 12, and 24 h post-methadone dose.
RESULTS: Patients exhibited a significantly shorter mean pain tolerance time of 34.17 s (95% CI 24.86, 43.49) versus 61.36 (52.23, 70.48) [p < 0.001] compared with opioid naive subjects. Time-dependent mean pain tolerance was also significantly different when naive subjects were compared to patients (p = 0.016).
CONCLUSIONS: This study revealed hyperalgesia amongst patients on MMT, as manifested by their quicker hand withdrawal. The complaints of pain in this population should not be underestimated and the pain should be evaluated seriously and managed aggressively.

Matched MeSH terms: Drug Tolerance