Displaying publications 21 - 40 of 1027 in total

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  1. Ang AH, Lambeth JT, Soo YS, Ong SC
    Med J Malaya, 1970 Sep;25(1):8-16.
    PMID: 4249503
    Matched MeSH terms: Kidney/abnormalities; Kidney/blood supply; Kidney/injuries; Kidney Diseases/radiography*; Kidney Neoplasms/radiography; Kidney Diseases, Cystic/radiography
  2. Segasothy M, Kong BCT, Kamal A, Murad Z, Suleiman AB
    Med J Malaysia, 1983 Dec;38(4):315-9.
    PMID: 6599990
    A prospective study was performed on patients admitted to the medical and renal wards of General Hospital, Kuala Lumpur. Over a period of 14 months from 1 January 1982, 12 new cases of analgesic nephropathy (AN) were documented. Contrary to the experience in the West and in Australia, AN in Malaysia tends to have a male preponderance and occurs even in the younger age groups. The common analgesics abused are paracetamol, Chap Kaki Tiga and Chap Harimau. The main reasons for analgesic abuse are headache and arthritis. In addition to radiological features of renal papillary necrosis patients have the other manifestations of the disease such as peptic ulceration, anaemia, neuro-psychiatric disorders and ischaemic heart disease.
    Matched MeSH terms: Kidney/radiography; Kidney Diseases/chemically induced*; Kidney Diseases/epidemiology; Kidney Diseases/radiography; Kidney Papillary Necrosis/chemically induced; Kidney Papillary Necrosis/radiography
  3. Suleiman AB
    Ann Acad Med Singap, 1987 Apr;16(2):238-9.
    PMID: 3688799
    Haematuria is always a significant finding that requires proper evaluation, and investigations may need to be initiated based on an adequate history. A careful urine microscopy of the urine using phase contrast microscopy is essential, and may predict the source of the haematuria based on red cell morphology, and point the direction that appropriate investigation should take. Infection tumours, obstruction; and calculi account for most cases of gross haematuria in adults. In paediatric patients, the causes of gross haematuria are readily apparent in half of the cases, but further investigations are necessary in the other half. All cases of haematuria require prompt evaluation and appropriate investigations to ensure correct and early treatment.
    Matched MeSH terms: Kidney Diseases/complications; Kidney Diseases/diagnosis
  4. Yusof MR, Fahmey O, Lee C, Azli MS, Arunasalam AP, Khairul-Asri MG
    Ann R Coll Surg Engl, 2022 Mar;104(3):e64-e66.
    PMID: 34812656 DOI: 10.1308/rcsann.2021.0110
    Renal cell carcinoma (RCC) has been shown to cause venous migration in the inferior vena cava (IVC). It is very important for preoperative imaging to be carried out, which will decide the surgical approach for the patient. Duplication of IVC is an uncommon anomaly. We report a case of RCC with duplication of IVC.
    Matched MeSH terms: Kidney/pathology; Kidney/surgery
  5. Annamalai C, Govindaraja C, Chandramouli C
    N Am J Med Sci, 2011 Dec;3(12):540-3.
    PMID: 22363074 DOI: 10.4297/najms.2011.3540
    Hypertension continues to be a major causative factor contributing to cardiovascular, cerebrovascular and renal morbidity and mortality.
    Matched MeSH terms: Kidney
  6. Chong FW, Chakravarthi S, Nagaraja HS, Thanikachalam PM, Lee N
    Malays J Pathol, 2009 Jun;31(1):35-43.
    PMID: 19694312
    Cyclosporine A (CsA), a calcineurin inhibitor produced by the fungi Trichoderma polysporum and Cylindrocarpon lucidum, is an immunosuppressant prescribed in organ transplants to prevent rejection. Its adverse effect on renal dysfunction has limited its use in a clinical setting. Apigenin (4',5',7'-Trihydroxyflavone), a herbal extract, with anti-inflammatory and anti-tumour properties, has been investigated for properties to reverse this adverse effect. This research was conducted to establish a standard protocol for immunohistochemical estimation of Transforming Growth Factor beta (TGF-beta) expression, as an indicator of Cyclosporine A induced damage, and to observe whether apoptotic index and TGF-beta expression can be used to assess effects of Apigenin on CsA induced renal dysfunction. Six groups of 5 male Sprague-Dawley albino rats each were dosed once daily for 21 days, as follows: (1) negative control--oral corn oil, (2) positive control--Cyclosporine A (25 mg/kg), (3) Group 3--Apigenin (20 mg/kg), (4) Group 4--Cyclosporine A (25 mg/kg) +Apigenin (10 mg/kg), (5) Group 5--Cyclosporine A (25 mg/kg) +Apigenin (15 mg/kg) and (6) Group 6--Cyclosporine A (25 mg/kg) +Apigenin (20 mg/kg). Cyclosporine A was administered intra-peritoneally while Apigenin was given orally. The rat kidneys were harvested and examined microscopically to assess the apoptotic index, and stained by immunohistochemistry for multifunctioning polypeptide TGF-beta expression. A high apoptotic index and TGF-beta intensity was observed in the Cyclosporine A group. Apigenin significantly reduced the both apoptotic index and TGF-beta intensity. The apoptotic index correlated with TGF-beta intensity, especially in glomeruli. This study indicates that Cyclosporine A can enhance the TGF-beta expression in rat kidney, signifying accelerated apoptosis. TGF-beta and apoptotic index may be used to assess Apigenin and its effect on Cyclosporine A induced renal damage.
    Matched MeSH terms: Kidney/drug effects; Kidney/metabolism; Kidney/pathology; Kidney Diseases/chemically induced; Kidney Diseases/pathology; Kidney Diseases/prevention & control*; Kidney Glomerulus/drug effects; Kidney Glomerulus/metabolism; Kidney Glomerulus/pathology; Kidney Tubules/drug effects; Kidney Tubules/metabolism; Kidney Tubules/pathology
  7. Cheong IK, Chong SM, Singh N, Suleiman AB
    Med J Malaysia, 1981 Mar;36(1):8-10.
    PMID: 7321940
    We report this 21 years old Indian male with the nephrotic syndrome due to membranous nephropathy who later developed numerous epithelial crescents leading to a rapid loss of renal function. The pathogenesis of the crescentic transformation in this type of glomerulopathy is discussed.
    Matched MeSH terms: Kidney Glomerulus/pathology*; Acute Kidney Injury/etiology
  8. Sreenevasan G
    Br J Urol, 1970 Dec;42(6):741.
    PMID: 5497398
    Matched MeSH terms: Kidney Failure, Chronic/therapy*; Acute Kidney Injury/therapy*
  9. Tan GC, Prasad V
    Int. J. Surg. Pathol., 2018 Feb;26(1):34.
    PMID: 28508688 DOI: 10.1177/1066896917709946
    Matched MeSH terms: Kidney/pathology*; Kidney Neoplasms/pathology*
  10. Sathyamoorthy P
    Family Physician, 1989;1:52-56.
    Matched MeSH terms: Kidney
  11. Martin P, Awan AA, Berenguer MC, Bruchfeld A, Fabrizi F, Goldberg DS, et al.
    Kidney Int, 2022 Dec;102(6):1228-1237.
    PMID: 36411019 DOI: 10.1016/j.kint.2022.07.012
    Infection with the hepatitis C virus (HCV) has adverse liver, kidney, and cardiovascular consequences in patients with chronic kidney disease (CKD), including those on dialysis therapy or with a kidney transplant. Since the publication of the Kidney Disease: Improving Global Outcomes (KDIGO) HCV Guideline in 2018, advances in HCV management, particularly in the field of antiviral therapy and treatment of HCV-associated glomerular diseases, coupled with increased usage of HCV-positive kidney grafts, have prompted a reexamination of the 2018 guideline. As a result, the Work Group performed a comprehensive review and revised the 2018 guidance. This Executive Summary highlights key aspects of the updated guideline recommendations for 3 chapters: Chapter 2: Treatment of HCV infection in patients with CKD; Chapter 4: Management of HCV-infected patients before and after kidney transplantation; and Chapter 5: Diagnosis and management of kidney diseases associated with HCV infection.
    Matched MeSH terms: Kidney
  12. Borges FK, Devereaux PJ, Cuerden M, Sontrop JM, Bhandari M, Guerra-Farfán E, et al.
    Am J Kidney Dis, 2022 Nov;80(5):686-689.
    PMID: 35346742 DOI: 10.1053/j.ajkd.2022.01.431
    Matched MeSH terms: Kidney
  13. Priyanka G, Poh EY, Yeong SS
    Med J Malaysia, 2013 Dec;68(6):473-4.
    PMID: 24632917
    Angiomyolipomas (AML) are the most common mesenchymal renal neoplasms arising in the cortex or medulla. Intra-renal and retroperitoneal hemorrhages have been frequently reported. AML can exceptionally involve the renal vein and inferior vena cava. We report a case with extension into the inferior vena cava.
    Matched MeSH terms: Kidney; Kidney Neoplasms
  14. Tumin M, Noh A, Chong CS, Mohd Satar N, Lim SK, Abdullah N, et al.
    Ann. Transplant., 2013;18:314-9.
    PMID: 23792535 DOI: 10.12659/AOT.883957
    This paper aimed to assess the willingness of Malaysians with post-secondary education to be living kidney donors.
    Matched MeSH terms: Kidney Transplantation*
  15. Hooi LS
    Med J Malaysia, 2006 Dec;61(5):513-5.
    PMID: 17623948
    Matched MeSH terms: Kidney Failure, Chronic/therapy*
  16. Koh, P.S., Muhilan, P., Dublin, N., Razack, A.H.
    JUMMEC, 2009;12(1):39-43.
    MyJurnal
    Renal angiomyolipoma, once considered a rare benign renal tumour, is relatively common these days. They account for 0.3-3.0% of all renal masses. Histologically, it is composed of adipose tissue, smooth muscles and blood vessels. Here, we wish to highlight five cases of renal angiomyolipomas which were presented to the University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia, over a two-year period between June 2005 and June 2007. This study wish to illustrate its varied clinical presentation and the management undertaken for each underlying condition. These cases were presented in the form of spontaneous perirenal haemorrhage, a large asymptomatic renal mass, a small asymptomatic renal mass, a symptomatic renal angiomyolipoma and a case of renal angiomyolipoma mimicking a renal tumour. Each of these cases varied in its clinical presentation; thus, management has become very challenging to clinicians ranging from conservative management to active intervention, be it operatively or non-operatively.
    Matched MeSH terms: Kidney; Kidney Neoplasms
  17. Zenab B. Hamad Mohamed, Hamad Abdulsalam Hamad Alfaris, Nor Zamila Abdullah, Norra Harun, Naznin Muhammad, Roslina Abdul Rahim
    MyJurnal
    Previous studies have proven the existence of a complex association
    between progressive kidney damage and hypercholesterolemia. Most studies focused on
    the impact of chronic high blood cholesterol levels on the kidney. Information on the
    early effect of hypercholesterolemia on the kidney is still lacking. The aim of this study
    was therefore to determine early effect of high cholesterol diet on the kidney in an
    animal model. (Copied from article).
    Matched MeSH terms: Kidney; Kidney Diseases
  18. Yap NY, Ong TA, Pailoor J, Gobe G, Rajandram R
    Biomarkers, 2023 Feb;28(1):24-31.
    PMID: 36315054 DOI: 10.1080/1354750X.2022.2142292
    Purpose: CD14-positive tumour and immune cells have been implicated in cancer progression. This study evaluated the prognostic significance of CD14 immunostaining in clear cell renal cell carcinoma (ccRCC) compared to the adjacent non-cancer kidney, and serum soluble CD14 (sCD14) levels in patients versus controls.Methods: Immunohistochemistry was performed for CD14 on ccRCC and the corresponding adjacent non-cancer kidney tissue from 88 patients. Staining intensity was determined using Aperio ImageScope morphometry. Serum sCD14 was evaluated for 39 ccRCC patients and 38 non-cancer controls using ELISA. CD14 levels were compared with tumour characteristics and survival status.Results: CD14 overall and nuclear immunostaining was higher in ccRCC compared to the adjacent non-cancer kidney tissue. CD14 nuclear immunostaining in the adjacent non-cancer kidney was significantly associated with advanced stage and adverse RCC survival prognosis. Serum sCD14 concentration was elevated in ccRCC patients compared to non-cancer controls and was also significantly associated with tumour stage and worse survival prognosis. Higher CD14 expression, in particular CD14 positive immune cell infiltrates found in the adjacent non-RCC kidney tissue, were associated with tumour progression and poorer prognosis.Conclusion: The levels of CD14 in non-RCC adjacent kidney and serum could be potential prognostic indicators.
    Matched MeSH terms: Kidney/metabolism
  19. Johan NH, Oo AP, Pisharam JK, Rosalina S, Koh D, Tan J
    Med J Malaysia, 2023 Jan;78(1):54-60.
    PMID: 36715192
    INTRODUCTION: The Brunei Dialysis and Transplant Registry (BDTR) recorded data on patients with end-stage kidney disease (ESKD) from 2011 to 2020, mainly for planning of services and benchmarking of standards. We report the trends of epidemiologic and performance parameters, compare performances between modalities of Kidney Replacement Therapy and evaluate the survival of ESKD patients over the 10-year period.

    MATERIALS AND METHODS: Three groups of data were analysed from the BDTR over the 10-year period. Epidemiological data, blood parameters and dialysis are key performance indicators.

    RESULTS: There are increments in prevalence and incidence of treated ESKD patients in Brunei over 10 years, especially with haemodialysis (HD). The projected prevalence and incidence showed an anticipated annual increase of 42.2 per million population (pmp) and 9.9 pmp respectively. Diabetes mellitus (DM) (79%) was the main cause of ESKD. HD (86%), peritoneal dialysis (PD) (9%) and transplant (5%) were the main modalities of kidney replacement therapy in 2020. Cumulative results over the decade showed significant improvements in serum phosphate, peritonitis rates and HD blood flow rates. PD patients have better survival rates, lower systolic blood pressure and better adequacy. PD survival (patient survival of 91%, 73% and 56% at 1, 3 and 5 years respectively) was superior to HD survival (86% and 64% at 1 and 2 years, respectively), but patient demographics (age and DM status) were different. The 2020 dataset showed satisfactory anaemia management but mineral bone disease management was sub-optimal. Seventy percent of prevalent HD patients had arteriovenous fistula access. Thirty-two percent and fifty-two percent of HD and PD patients, respectively, achieved target dialysis adequacy. Peritonitis rate was 0.3 episodes per patient year.

    CONCLUSION: Brunei has a high incidence and prevalence of treated ESKD in the last decade, especially DM-related ESKD. This study has identified many specific areas to be targeted for improvements and provided evidence for further proliferation of PD and transplant preference policy.

    Matched MeSH terms: Kidney Transplantation*
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