MyMedR

Mucoepidermoid carcinoma of the thyroid: a case report

Jayaram G, Wong KT, Jalaludin MA

Malays J Pathol, 1998 Jun;20(1):45-8.

Primary mucoepidermoid carcinoma (MEC) of thyroid is an uncommon tumour and reports on its' cytology are consequently scanty. A 46-year-old male presented with a thyroid nodule of nine months duration. Fine needle aspiration (FNA) cytology of the nodule showed features of a malignant tumor that was different from the usual types of thyroid carcinoma. Monolayers and syncytial clusters of round and spindle tumour cells with large vesicular nuclei and single macronucleoli were present. A diagnosis of carcinoma was given with the comment that this was unlike any of the usual types of thyroid cancer and that a metastatic malignancy should be ruled out. The cytological picture of MEC may not always be distinctive enough for accurate tumour typing. Nevertheless the cytological features are usually sufficiently different to rule out all of the usual types of thyroid carcinoma. This distinction may be important from the point of view of differing prognosis in MEC of thyroid (as compared to differentiated thyroid cancers) and the need to exclude a metastatic carcinoma, especially from a primary in one of the salivary glands.

Matched MeSH terms: Thyroid Neoplasms/pathology*

Fulltext The experience with fine needle aspiration cytology in the management of palpable breast lumps in the University Hospital Kuala Lumpur

Yip CH, Jayaram G, Alhady SF

Med J Malaysia, 2000 Sep;55(3):363-7.

PMID: 11200718

A total of 676 palpable breast lumps seen in the Breast Clinic, University Hospital, Kuala Lumpur from August 1993 to August 1994 were subjected to fine needle aspiration cytology. Fifty-four were reported as inadequate, 501 benign, 95 malignant and 26 suspicious. One hundred and eighty-seven aspirates had histological correlation, while 34 of the malignant aspirates had clinical correlation. The majority of the other 455 patients were followed up for a period of 60 to 72 months without any malignancies becoming apparent. For analysis, only the 221 cases with histological or clinical correlation were included, (the suspicious category was included into the positive group and the inadequate cases were excluded), giving a sensitivity of 91.7%, a specificity of 91.7% and a diagnostic accuracy of 91.7%. Breast cytology was an accurate and rapid method of diagnosis of breast diseases, and in a busy surgical unit with limited operating time, it allowed for the triage of patients with breast complaints in deciding which cases needed early open biopsy. A negative cytology does not exclude the possibility of cancer, as there was a false negative rate of 11%. However by utilising a diagnostic triad of clinical examination, radiological assessment and fine needle aspiration cytology, the risk of missing a malignancy is small.

Matched MeSH terms: Breast Neoplasms/pathology*

Fulltext Metastatic disease of the proximal femur

Faisham WI, Zulmi W, Biswal BM

Med J Malaysia, 2003 Mar;58(1):120-4.

PMID: 14556337

Since January 1999, ten patients had undergone surgical treatment for metastatic bony lesions of proximal femur at this centre. Seven of these patients were treated for complete pathological fractures, one for impending fracture and one for revision of internal fixation and loosening of hemiarthroplasty. Primary malignancies were located in breast in four cases, prostate in three and one in lung, thyroid and neurofibrosarcoma. Two patients had died within six months after surgery, four after 1 year while the remaining four were still alive. The mean duration of survival was eleven months. Nine patients had been ambulating pain free and there were no failure of reconstruction.

Matched MeSH terms: Breast Neoplasms/pathology*; Lung Neoplasms/pathology*; Prostatic Neoplasms/pathology*; Thyroid Neoplasms/pathology*

Fulltext Adenocarcinoma of rectum metastasizing to penis

Sukumar N, Qureshi A

Med J Malaysia, 2001 Jun;56(2):255-6.

PMID: 11771091

An elderly gentleman with adenocarcinoma of the rectum who had abdominoperineal resection presented with scrotal skin and penile metastasis. Adenocarcinoma of the rectum metastasizing to the groin and penis is very rare and few cases have been reported.

Matched MeSH terms: Rectal Neoplasms/pathology*

Eccrine cylindroma of the ear canal--report of a case

Sharma HS, Meorkamal MZ, Zainol H, Dharap AS

J Laryngol Otol, 1994 Aug;108(8):706-9.

PMID: 7930929

Eccrine cylindroma is a benign tumour arising from sweat glands in the skin. It favours the face, forehead and scalp involving the turban area and hence is called a turban tumour. Amongst a variety of tumours originating from adnexal skin structures, which may appear in the ear canal, eccrine cylindroma forms a very rare entity. We present such a case and discuss its pathological and clinical features.

Matched MeSH terms: Ear Neoplasms/pathology*

Fulltext Fertility drugs and rapid growth of leiomyomata

Rachagan SP

Med J Malaysia, 1994 Dec;49(4):428.

PMID: 7674984

Matched MeSH terms: Uterine Neoplasms/pathology*

Fulltext Malignant conjunctival melanoma. A case report

Kandiah R, Sukumaran K, Chandran S, Jayalakshmi P

Med J Malaysia, 1988 Jun;43(2):178-80.

PMID: 3237135

Matched MeSH terms: Conjunctival Neoplasms/pathology*

Angiomyolipoma of the vagina--an uncommon tumour. Case report

Peh SC, Sivanesaratnam V

Br J Obstet Gynaecol, 1988 Aug;95(8):820-3.

PMID: 3166957

Matched MeSH terms: Vaginal Neoplasms/pathology*

Mucoepidermoid carcinoma of the trachea (a case report)

Said H, Phang KS, Gibb AG

J Laryngol Otol, 1988 Jan;102(1):83-6.

PMID: 3343572

A case of mucoepidermoid carcinoma of the trachea in a 26-year-old female is presented. Diagnosis was confirmed by histopathology. On the basis of the clinical and histological picture, the tumour is classified as a low grade mucoepidermoid carcinoma. Conservative surgical treatment was the primary mode of treatment. The patient showed no clinical evidence of recurrence twelve months after local resection of the tumour.

Matched MeSH terms: Tracheal Neoplasms/pathology*

Fulltext Two cases of human sarcocystosis in East Malaysia

Pathmanathan R, Kan SP

Med J Malaysia, 1987 Sep;42(3):212-4.

PMID: 3147362

The first two cases of human muscular sarcocystosis are reported from East Malaysia, in Sabalt and Sarawak respectively. Sarcocysts were seen iin biopsied specimen from the nasopharynx of both patients who had carcinoma of the nasopharynx. The measurements and appearances of the cysts and the zoites within the cysts were compared with the human cases of sarcocystosis previously reported in West Malaysia. Zoonotic and other aspects of these cases of East Malaysian sarcocystosis are discussed.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Calcifying and keratinizing ameloblastoma of the maxilla

Siar CH, Ng KH

J Laryngol Otol, 1991 Nov;105(11):971-2.

PMID: 1722237

A case is described of ameloblastoma of maxilla presenting with numerous calcified keratin pearls. The significance of cellular variation in relation to the behavioural potential of the ameloblastoma in general is briefly discussed.

Matched MeSH terms: Maxillary Neoplasms/pathology*

Fulltext Metastatic malignant schwannoma of orbit: a case report

Jaais F, Sivanesan S

Med J Malaysia, 1986 Dec;41(4):356-60.

PMID: 3670161

A case of metastatic malignant schwannoma of the right orbit is presented here. Although the patient had disseminated disease, it was the eye problems which were striking and most symptomatic.
The orbital lesion was at first thought to be the primary tumour until a history of an excised right wrist mass was probed into and the histology traced.
This report is written as malignant schwannoma is an uncommon tumour. The difficulty in diagnosing malignant schwannoma is mentioned. The importance of diagnosis of an orbital metastatic lesion is also pointed out as this is often misdiagnosed.

Matched MeSH terms: Orbital Neoplasms/pathology

Fulltext Extrarenal Wilms' tumour

Looi LM, Jagadeesan K

Med J Malaysia, 1983 Jun;38(2):134-6.

PMID: 6312279

A rare case of extrarenal Wilms' tumour in a Kadazan child is presented with a description of its clinical and pathological features. The possible origin of this tumour is discussed

Matched MeSH terms: Retroperitoneal Neoplasms/pathology*

Neurogenous tumour of the larynx (a case report)

Phang WK, Raman R, Jayalaksmi E

J Laryngol Otol, 1987 Nov;101(11):1209-10.

PMID: 3694036

Matched MeSH terms: Laryngeal Neoplasms/pathology

A case of primary adenocarcinoma of the fallopian tube

Ong HC, Chan WF, Sinnathuray TA

Med J Malaysia, 1978 Mar;32(3):217-9.

PMID: 683046

Matched MeSH terms: Fallopian Tube Neoplasms/pathology*

Fulltext Extraneural metastasis of meningeal haemangiopericytoma to the liver

Yusoff AR, Mokhtar S, Raman K, Singh H, Shabery NAM

Turk J Gastroenterol, 2019 09;30(9):848-850.

PMID: 31530530 DOI: 10.5152/tjg.2019.18454

Matched MeSH terms: Meningeal Neoplasms/pathology*

Epigenetics: The master control of endothelial cell fate in cancer

V Subramaniam A, Yehya AHS, Cheng WK, Wang X, Oon CE

Life Sci, 2019 Sep 01;232:116652.

PMID: 31302197 DOI: 10.1016/j.lfs.2019.116652

The development of new blood vessels from pre-existing vasculature is called angiogenesis. The growth of tumors depends on a network of supplying vessels that provide them with oxygen and nutrients. Pro-angiogenic factors that are secreted by tumors will trigger the sprouting of nearby existing blood vessels towards themselves and therefore researchers have developed targeted therapy towards these pro-angiogenic proteins to inhibit angiogenesis. However, certain pro-angiogenic proteins tend to bypass the inhibition. Thus, instead of targeting these expressed proteins, research towards angiogenesis inhibition had been focused on a deeper scale, epigenetic modifications. Epigenetic regulatory mechanisms are a heritable change in a sequence of stable but reversible gene function modification yet do not affect the DNA primary sequence directly. Methylation of DNA, modification of histone and silencing of micro-RNA (miRNA)-associated gene are currently considered to initiate and sustain epigenetic changes. Recent findings on the subject matter have provided an insight into the mechanism of epigenetic modifications, thus this review aims to present an update on the latest studies.

Matched MeSH terms: Neoplasms/pathology*

Atypical peripheral ameloblastoma of the palate

Siar CH, Ng KH, Ngui CH, Chuah CH

J Laryngol Otol, 1990 Mar;104(3):252-4.

PMID: 2341785

Clinical, radiological and histological characteristics of the peripheral ameloblastoma are briefly outlined. A case found occurring in the palate and presenting with atypical histological features is reported. The differential diagnosis of this lesion, its treatment and histogenesis are discussed.

Matched MeSH terms: Palatal Neoplasms/pathology*

Primary follicular lymphoma of the pancreas: A rare tumour mimicking pancreatic carcinoma

Sallapan S, Abu Bakar NZ, Jarmin R, Masir N, Mohammed F

Malays J Pathol, 2018 Dec;40(3):359-371.

PMID: 30580370

INTRODUCTION: Primary pancreatic lymphomas are extremely rare. Clinically, primary pancreatic lymphoma mimics symptoms of carcinoma of the pancreatic head. Clinical and radiological features may overlap with other pancreatic conditions such as carcinoma, neuroendocrine tumours and autoimmune pancreatitis.

CASE REPORT: We report a case of a 75-year-old man who presented with symptoms of obstructive jaundice. Ultrasonography and computed tomography (CT) showed an ill-defined lobulated soft tissue lesion at the head/uncinate process of the pancreas measuring 4.5 x 4.9 x 5.8 cm. The patient underwent pancreaticoduodenectomy for suspected pancreatic head/uncinate process carcinoma. Histopathology and immunohistochemical assessment of the pancreatic lesion established the diagnosis of a low-grade follicular lymphoma.

DISCUSSION: Clinical and imaging features of primary pancreatic lymphoma may often overlap with pancreatic carcinoma. There is a value of obtaining preoperative tissue diagnosis such as tissue biopsy and fine needle aspiration (FNA) cytology with or without flow cytometry to make an accurate diagnosis of non-Hodgkin lymphoma and alleviate the need of more radical surgery in pancreatic lymphoma.

Matched MeSH terms: Pancreatic Neoplasms/pathology*

Meta-analysis of histopathological outcomes of laparoscopic assisted rectal resection (LARR) vs open rectal resection (ORR) for carcinoma

Memon MA, Awaiz A, Yunus RM, Memon B, Khan S

Am J Surg, 2018 11;216(5):1004-1015.

PMID: 29958656 DOI: 10.1016/j.amjsurg.2018.06.012

BACKGROUND: We conducted a meta-analysis of the randomized evidence to determine the relative merits of histopathological outcomes of laparoscopic assisted (LARR) versus open rectal resection (ORR) for rectal cancer.

DATA SOURCES: A search of PubMed and other electronic databases comparing LARR and ORR between Jan 2000 and June 2016 was performed. Histopathological variables analyzed included; location of rectal tumors; complete and incomplete TME; positive and negative circumferential resection margins (+/-CRM); positive distal resected margins (+DRM); distance of tumor from DRM; number of lymph nodes harvested; resected specimen length; tumor size and perforated rectum.

RESULTS: Fourteen RCTs totaling 3843 patients (LARR = 2096, ORR = 1747) were analyzed. Comparable effects were noted for all these histopathological variables except for the variable perforated rectum which favored ORR.

CONCLUSIONS: LARR compares favorably to ORR for rectal cancer treatment. However, there is significantly higher risk of rectal perforation during LARR compared to ORR.

Matched MeSH terms: Rectal Neoplasms/pathology

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