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Racial characteristics of human teeth with special emphasis on the Mongoloid dentition

Yaacob H, Nambiar P, Naidu MD

Malays J Pathol, 1996 Jun;18(1):1-7.
PMID: 10879216

Determining the racial affinity of an unknown individual from dentition for identification is indeed a difficult endeavour. However, there are certain dental characteristics which are predominant in certain racial groups and these contribute important indicators in the identification process. Inherited dental characteristics are modified by prenatal and postnatal environmental and nutritional conditions. They can also become less discernible due to admixture of the various races.

Matched MeSH terms: Tooth/anatomy & histology*
Diagnostic ability of computed tomography using DentaScan software in endodontics: case reports

Siotia J, Gupta SK, Acharya SR, Saraswathi V

Int J Comput Dent, 2011;14(4):321-34.
PMID: 22324223

Radiographic examination is essential in diagnosis and treatment planning in endodontics. Conventional radiographs depict structures in two dimensions only. The ability to assess the area of interest in three dimensions is advantageous. Computed tomography is an imaging technique which produces three-dimensional images of an object by taking a series of two-dimensional sectional X-ray images. DentaScan is a computed tomography software program that allows the mandible and maxilla to be imaged in three planes: axial, panoramic, and cross-sectional. As computed tomography is used in endodontics, DentaScan can play a wider role in endodontic diagnosis. It provides valuable information in the assessment of the morphology of the root canal, diagnosis of root fractures, internal and external resorptions, pre-operative assessment of anatomic structures etc. The aim of this article is to explore the clinical usefulness of computed tomography and DentaScan in endodontic diagnosis, through a series of four cases of different endodontic problems.

Matched MeSH terms: Tooth Root/injuries
Fulltext Protective effects of stem cells from human exfoliated deciduous teeth derived conditioned medium on osteoarthritic chondrocytes

Muhammad SA, Nordin N, Hussin P, Mehat MZ, Abu Kasim NH, Fakurazi S

PLoS One, 2020;15(9):e0238449.
PMID: 32886713 DOI: 10.1371/journal.pone.0238449

Treatment of osteoarthritis (OA) is still a major clinical challenge due to the limited inherent healing capacity of cartilage. Recent studies utilising stem cells suggest that the therapeutic benefits of these cells are mediated through the paracrine mechanism of bioactive molecules. The present study evaluates the regenerative effect of stem cells from human exfoliated deciduous teeth (SHED) conditioned medium (CM) on OA chondrocytes. The CM was collected after the SHED were cultured in serum-free medium (SFM) for 48 or 72 h and the cells were characterised by the expression of MSC and pluripotency markers. Chondrocytes were stimulated with interleukin-1β and treated with the CM. Subsequently, the expression of aggrecan, collagen type 2 (COL 2), matrix metalloproteinase-13 (MMP-13), nuclear factor-kB (NF-kB) and the level of inflammatory and anti-inflammatory markers were evaluated. SHED expressed mesenchymal stromal cell surface proteins but were negative for haematopoietic markers. SHED also showed protein expression of NANOG, OCT4 and SOX2 with differential subcellular localisation. Treatment of OA chondrocytes with CM enhanced anti-inflammation compared to control cells treated with SFM. Furthermore, the expression of MMP-13 and NF-kB was significantly downregulated in stimulated chondrocytes incubated in CM. The study also revealed that CM increased the expression of aggrecan and COL 2 in OA chondrocytes compared to SFM control. Both CM regenerate extracellular matrix proteins and mitigate increased MMP-13 expression through inhibition of NF-kB in OA chondrocytes due to the presence of bioactive molecules. The study underscores the potential of CM for OA treatment.

Matched MeSH terms: Tooth, Deciduous/metabolism
Linkage analysis and whole exome sequencing reveals AHNAK2 as a novel genetic cause for autosomal recessive CMT in a Malaysian family

Tey S, Shahrizaila N, Drew AP, Samulong S, Goh KJ, Battaloglu E, et al.

Neurogenetics, 2019 08;20(3):117-127.
PMID: 31011849 DOI: 10.1007/s10048-019-00576-3

Charcot-Marie-Tooth (CMT) disease is a form of inherited peripheral neuropathy that affects motor and sensory neurons. To identify the causative gene in a consanguineous family with autosomal recessive CMT (AR-CMT), we employed a combination of linkage analysis and whole exome sequencing. After excluding known AR-CMT genes, genome-wide linkage analysis mapped the disease locus to a 7.48-Mb interval on chromosome 14q32.11-q32.33, flanked by the markers rs2124843 and rs4983409. Whole exome sequencing identified two non-synonymous variants (p.T40P and p.H915Y) in the AHNAK2 gene that segregated with the disease in the family. Pathogenic predictions indicated that p.T40P is the likely causative allele. Analysis of AHNAK2 expression in the AR-CMT patient fibroblasts showed significantly reduced mRNA and protein levels. AHNAK2 binds directly to periaxin which is encoded by the PRX gene, and PRX mutations are associated with another form of AR-CMT (CMT4F). The altered expression of mutant AHNAK2 may disrupt the AHNAK2-PRX interaction in which one of its known functions is to regulate myelination.

Matched MeSH terms: Charcot-Marie-Tooth Disease/genetics*
Fulltext The Use of Hall's Technique Preformed Metal Crown (HTPMC) by Pediatric Dentists in Malaysia

Jesmin F, Kamarudin A, Baharin F, Ahmad WMABW, Mohammed M, Marya A, et al.

Biomed Res Int, 2021;2021:8424206.
PMID: 34977246 DOI: 10.1155/2021/8424206

Introduction: Hall's technique preformed metal crown (HTPMC) has been used widely by pediatric dentists in developed countries as a new approach for managing decayed primary molars without local anesthesia, caries removal, and tooth preparation. Currently, inadequate information is available regarding the implementation of this technique (HTPMC) in Malaysia. This study is aimed at evaluating the implementation of HTPMC by Malaysia's pediatric dentists and identify the co-occurrence frequencies of the HTPMC implementation with the respondents' demographic profile.
Materials and Methods: A cross-sectional questionnaire-based research was conducted among 65 pediatric dentists in Malaysia. Online questionnaires were distributed to the pediatric dentists employed at public hospitals (MOH) and universities in Malaysia.
Result: It was found that over half of the respondents (65.6%) employed HTPMC. The analysis of the co-occurrence network frequency revealed that a high frequency of female pediatric dentists who were within the age group of 31-40 years old had fulfilled their postgraduation overseas and was employed in the university mainly applied HTPMC.
Conclusion: The application of HTPMC among respondent pediatric dentists in Malaysia was high. However, most respondents considered HTPMC a treatment option only to manage carious primary molar rather than a treatment of choice.

Matched MeSH terms: Tooth, Deciduous/surgery
Fulltext The implications of different lateral wall thicknesses on surgical access to the maxillary sinus

Lim EL, Ngeow WC, Lim D

Braz Oral Res, 2017 Nov 27;31:e97.
PMID: 29185606 DOI: 10.1590/1807-3107bor-2017.vol31.0097

The objective of this study was to measure the topographic thickness of the lateral wall of the maxillary sinus in selected Asian populations. Measurements were made on the lateral walls of maxillary sinuses recorded using CBCT in a convenient sample of patients attending an Asian teaching hospital. The points of measurement were the intersections between the axes along the apices of the canine, first premolar, and second premolar and along the mesiobuccal and distobuccal apices of the first and second molars and horizontal planes 10 mm, 20 mm, 30 mm and 40 mm beneath the orbital floor. The CBCT images of 109 patients were reviewed. The mean age of the patients was 33.0 (SD 14.8) years. Almost three quarters (71.8%) of the patients were male. The mean bone thickness decreased beginning at the 10-mm level and continuing to 40 mm below the orbital floor. Few canine regions showed encroachment of the maxillary sinus. The thickness of the buccal wall gradually increased from the canine region (where sinus encroachment of the canine region was present) to the first molar region, after which it decreased to the thickness observed at the canine region. The buccal wall of the maxillary sinus became thicker anteroposteriorly, except in the region of the second molar, and thinner superoinferiorly. These changes will affect the approach used to osteotomize the lateral sinus wall for oral surgery and for the sinus lift procedure.

Matched MeSH terms: Tooth/anatomy & histology
Malaysian undergraduates' knowledge and opinions on Early Childhood oral health

Mani SA, Burhanudin NA, John J

Eur J Paediatr Dent, 2012 Mar;13(1):64-8.
PMID: 22455531

AIM: In Malaysia, Early Childhood Caries (ECC) was found to affect 76.2% of 5-year-olds (2005). General practitioners are more likely to encounter preschool children and are in a better position to educate parents and caretakers about ECC and make appropriate referrals. This study assessed the knowledge and opinions on early childhood oral health among medical and dental undergraduates.
MATERIALS AND METHODS: This cross sectional study involved 245 students enrolled in the first year medical (M1) and dental (D1) course and fourth year medical (M4) and dental (D4) course. The students completed a self-administered questionnaire which included knowledge and opinions on early childhood oral health. Comparisons between the groups were done using chi-square test.
RESULTS: Dental students showed significantly better knowledge than medical students. D1 students showed significantly better knowledge of age of first tooth eruption over M1. Knowledge of recommended age for bottle weaning was higher among D4 students but not significantly more than M4 students.
CONCLUSION: The majority of medical students showed inadequate knowledge indicating that medical curriculum should emphasise on oral health topics of public health relevance like ECC and its prevention. Dental students had better knowledge regarding early childhood oral health, but lacked knowledge on its preventive aspects.

Matched MeSH terms: Tooth Eruption/physiology
Fulltext 3D mapping of safe and danger zones in the maxilla and mandible for the placement of intermaxillary fixation screws

Purmal K, Alam MK, Pohchi A, Abdul Razak NH

PLoS One, 2013;8(12):e84202.
PMID: 24367643 DOI: 10.1371/journal.pone.0084202

Intermaxillary (IMF) screws feature several advantages over other devices used for intermaxillary fixation, but using cone beam computed tomography (CBCT) scans to determine the safe and danger zones to place these devices for all patients can be expensive. This study aimed to determine the optimal interradicular and buccopalatal/buccolingual spaces for IMF screw placement in the maxilla and mandible. The CBCT volumetric data of 193 patients was used to generate transaxial slices between the second molar on the right to the second molar on the left in both arches. The mean interradicular and buccopalatal/buccolingual distances and standard deviation values were obtained at heights of 2, 5, 8 and 11 mm from the alveolar bone crest. An IMF screw with a diameter of 1.0 mm and length of 7 mm can be placed distal to the canines (2 - 11 mm from the alveolar crest) and less than 8 mm between the molars in the maxilla. In the mandible, the safest position is distal to the first premolar (more than 5 mm) and distal to the second premolar (more than 2 mm). There was a significant difference (p<0.05) between the right and left quadrants. The colour coding 3D template showed the safe and danger zones based on the mesiodistal, buccopalatal and buccolingual distances in the maxilla and mandible.The safest sites for IMF screw insertion in the maxilla were between the canines and first premolars and between the first and second molars. In the mandible, the safest sites were between the first and second premolars and between the second premolar and first molar. However, the IMF screw should not exceed 1.0 mm in diameter and 7 mm in length.

Matched MeSH terms: Tooth/radiography
Prevalence and patterning of maxillary premolar accessory ridges (MxPARs) in several human populations

Mihailidis S, Scriven G, Khamis M, Townsend G

Am. J. Phys. Anthropol., 2013 Sep;152(1):19-30.
PMID: 23913636 DOI: 10.1002/ajpa.22323

We present new data on the prevalence and patterning of the maxillary premolar accessory ridge (MxPAR), a common but understudied morphological dental trait that is expressed as a linear elevation extending from the buccal cusp ridge to the medial sulcus of maxillary premolar teeth. A total of 579 sets of dental casts, representing six ethnic groups, were scored using the five-grade system proposed by Burnett et al. (2010). The frequency and distribution of the MxPAR were determined by tooth type, sex, side, locus and ethnicity, and the applicability of the scoring system was assessed. The MxPAR was found in approximately two-thirds of premolar teeth, more often on second than first premolars, and more often on the distal aspect of the occlusal surface than the mesial. There was some evidence that more pronounced forms of the feature occurred more often in males than females, and that there may be some directionality in its expression between sides. Variation was also noted in the frequency of occurrence and degree of expression of the MxPAR between ethnic groups. Intra- and inter-observer concordance rates for scoring the MxPAR were low, confirming that it was difficult to score the trait identically on two different occasions. Our findings have clarified the distribution of the MxPAR within the dentition and between ethnic groups, and highlighted the need for researchers to carry out thorough replicability studies and to decide on an appropriate breakpoint for determining presence or absence of this feature before embarking on genetic studies or bio-distance analyses.

Matched MeSH terms: Tooth Crown/anatomy & histology*
Novel clinical applications of Colgate Sensitive Pro-Relief in the management of dentin hypersensitivity

Lin SL

J Clin Dent, 2012;23(1):7-10.
PMID: 22435318
Matched MeSH terms: Tooth Bleaching; Tooth Preparation
Fulltext Feasibility of fiber optic displacement sensor scanning system for imaging of dental cavity

Rahman HA, Che Ani AI, Harun SW, Yasin M, Apsari R, Ahmad H

J Biomed Opt, 2012 Jul;17(7):071308.
PMID: 22894469 DOI: 10.1117/1.JBO.17.7.071308

The purpose of this study is to investigate the potential of intensity modulated fiber optic displacement sensor scanning system for the imaging of dental cavity. Here, we discuss our preliminary results in the imaging of cavities on various teeth surfaces, as well as measurement of the diameter of the cavities which are represented by drilled holes on the teeth surfaces. Based on the analysis of displacement measurement, the sensitivities and linear range for the molar, canine, hybrid composite resin, and acrylic surfaces are obtained at 0.09667 mV/mm and 0.45 mm; 0.775 mV/mm and 0.4 mm; 0.5109 mV/mm and 0.5 mm; and 0.25 mV/mm and 0.5 mm, respectively, with a good linearity of more than 99%. The results also show a clear distinction between the cavity and surrounding tooth region. The stability, simplicity of design, and low cost of fabrication make it suitable for restorative dentistry.

Matched MeSH terms: Tooth/anatomy & histology*
Dental health status and treatment needs in the infantry regiment of the Malaysian Territorial Army

Jasmin B, Jaafar N

Asia Pac J Public Health, 2011 Apr;23(2):203-8.
PMID: 21159693 DOI: 10.1177/1010539510391234

The aim of this study was to determine the dental health status and treatment needs of personnel in the Infantry Regiment of the Malaysian Territorial Army (TA).This cross-sectional study involved stratified and systematic random sampling with a total sample size of 300. Dental health status and treatment needs were assessed using the standard WHO oral assessment criteria (1997). The prevalence of caries experience was 96% (mean ± SD DMFT [decayed, missing, filled teeth] = 8.0 ± 5.5). Active decay prevalence was high (85%; mean ± SD = 3.6 ± 3.1) indicating high unmet treatment need. Missing teeth prevalence was high (69%; mean ± SD = 2.8 ± 3.7). Filled teeth prevalence was low (56%, mean ± SD = 1.5 ± 2.0). In all, 90% of participants required some form of dental treatment, of whom 85% required restorative treatment, 5% advanced restorative treatment, 36.7% extractions, and 45.3% prosthetic treatment. These findings suggest that there was a high need for dental treatment in the Infantry Battalions of Malaysian TA Regiments and the service must be made available to cater to the needs.

Matched MeSH terms: Tooth Loss/epidemiology*
Is there a "safety zone" in the mandibular premolar region where damage to the mental nerve can be avoided if periapical extrusion occurs?

Ngeow WC

J Can Dent Assoc, 2010;76:a61.
PMID: 20579448
Matched MeSH terms: Tooth Apex/anatomy & histology*
Evaluation of bone healing following immediate and delayed dental implant placement

Younis L, Taher A, Abu-Hassan MI, Tin O

J Contemp Dent Pract, 2009;10(4):35-42.
PMID: 19575052

The purpose of this study was to compare bone healing and coronal bone remodeling following both immediate and delayed placement of titanium dental implants in extraction sockets.

Matched MeSH terms: Tooth Socket/surgery*
Amelogenesis imperfecta: enamel ultra structure and molecular studies

Gopinath VK, Al-Salihi KA, Yean CY, Ann MC, Ravichandran M

J Clin Pediatr Dent, 2004;28(4):319-22.
PMID: 15366620

Amelogenesis imperfecta (AI) is a hereditary disorder resulting in generalized defects in the enamel. The case reported here is of a seven-year-old male child with yellow color of all his teeth. Two of his primary molars were extracted due to dental abscess with advanced root resorption. Histologically hypoplastic enamel layer, positively birefringent, generalized pitting, roughness with irregular general cracked borders were observed. Scanning electron microscope, revealed extensive irregular, disorganized rough superficial enamel layer. The enamel was irregularly decussate with filamentous prisms accompanied by small rounded formations. The morphological and histological examination of the tooth revealed that this patient has the features of AI. For genetic study blood sample were collected from the patient and PCR analysis revealed that there is no mutation in exons 1-7 of AMELX gene on the X chromosome of the patient. Hence, it is probable that the AI of this patient is not X-linked. It is more likely to be an autosomal mutation.

Matched MeSH terms: Tooth, Deciduous/ultrastructure
The oral health of people with chronic schizophrenia: A neglected public health burden

Wey MC, Loh S, Doss JG, Abu Bakar AK, Kisely S

Aust N Z J Psychiatry, 2016 Jul;50(7):685-94.
PMID: 26560842 DOI: 10.1177/0004867415615947

OBJECTIVE: People with chronic schizophrenia have high rates of physical ill-health such as heart disease. However, there has been less attention to the issue of poor oral health including dental caries (tooth decay) and periodontal (gum) disease, although both have consequences for quality of life and systemic physical health. We therefore measured tooth decay and gum disease in Malaysians with schizophrenia.
METHODS: We recruited long-stay inpatients with schizophrenia from June to October 2014. Four dental specialists assessed oral health using the decayed-missing-filled teeth index, the Community Periodontal Index of Treatment Needs and the Debris Index of the Simplified Oral Hygiene Index. Results were compared with the 2010 Oral Health survey of the general Malaysian population.
RESULTS: A total of 543 patients participated (66.7% males, 33.3% females; mean age = 54.8 years [standard deviation = 16.0]) with a mean illness duration of 18.4 years (standard deviation = 17.1). The mean decayed-missing-filled teeth was 20.5 (standard deviation = 9.9), almost double that of the general population (11.7). Higher decayed-missing-filled teeth scores were associated with both older age (p tooth loss.
CONCLUSION: Dental disease in people with schizophrenia deserves the same attention as other comorbid physical illness. The disparity in oral health is most marked for dental decay. Possible interventions include oral health assessments using standard checklists designed for non-dental personnel, help with oral hygiene, management of iatrogenic dry mouth and early dental referral.

Matched MeSH terms: Tooth Loss/epidemiology*
Fulltext Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells

Aziz J, Abu Kassim NL, Abu Kasim NH, Haque N, Rahman MT

BMC Complement Altern Med, 2015;15:215.
PMID: 26152209 DOI: 10.1186/s12906-015-0749-6

Use of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines induction

Matched MeSH terms: Tooth, Deciduous/cytology
Sevoflurane for dental extraction in children with Tetralogy of Fallot

Chiu CL, Wang CY

Paediatr Anaesth, 1999;9(3):268-70.
PMID: 10320610

Two children with Tetralogy of Fallot presented for dental extraction. Anaesthesia was induced rapidly and smoothly by inhalation of sevoflurane. We discussed the advantages of sevoflurane as an induction agent as compared to halothane in these children.

Matched MeSH terms: Tooth Extraction*
Gaining access through a calcified pulp chamber: a clinical challenge

Ngeow WC, Thong YL

Int Endod J, 1998 Sep;31(5):367-71.
PMID: 9823142

Dental pulp is prone to dystrophic mineralization; this mineralization can be so extensive that the entire root canal system is obliterated. As a result, root canal treatment can become a difficult if not impossible task. This article presents the endodontic management of a tooth with an obliterated pulp chamber and associated with a discharging sinus in a teenage patient. The role of a calcium hydroxide lining to induce mineralization and cause the obliteration of the pulpal space is also discussed.

Matched MeSH terms: Tooth Injuries/complications
Histiocytosis X: evidence for a genetic etiology

Hanapiah F, Yaacob H, Ghani KS, Hussin AS

J Nihon Univ Sch Dent, 1993 Sep;35(3):171-4.
PMID: 8246038

Histiocytosis X is a rare disorder with no particular predilection for race, age or sex. Since its discovery by Hand in 1893, the etiology has remained unknown, although viruses, bacteria and genetic factors have been implicated. Familial occurrence of this disease is very rare, and only a handful of such cases have been reported. The present study adds further evidence to support the influence of genetic factors in the etiology of histiocytosis X.

Matched MeSH terms: Tooth Mobility/etiology

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