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Fulltext Live Attenuated Bacterial Vectors as Vehicles for DNA Vaccine Delivery: A Mini Review

Eng SW, Muniandy V, Punniamoorthy L, Tew HX, Norazmi MN, Ravichandran M, et al.

Malays J Med Sci, 2024 Dec;31(6):6-20.
PMID: 39830112 DOI: 10.21315/mjms2024.31.6.2

DNA vaccines are third-generation vaccines composed of plasmids that encode vaccine antigens. Their advantages include fast development, safety, stability, and cost effectiveness, which make them an attractive vaccine platform for genetic and infectious diseases. However, the low transfection efficiency of DNA vaccines results in poor performance in both larger animals and humans, thereby limiting their clinical use. To overcome this issue, live attenuated bacterial vector (LABV) has been proposed as a DNA delivery vehicle. LABV is known to improve DNA vaccine transfection efficiency, thus enhancing the immune response. This article highlights recent advancements in the development of LABV DNA vaccines, the design of shuttle plasmids and adjuvants, and the potential applications of LABV candidates.
Fulltext A Scoping Review on Medicinal Properties of Piper betle (Sirih) Based on Malay Medical Manuscripts and Scientific Literatures

Zamri NFI, Mohd Shafri MA, Zamli Z, Mamat S

Malays J Med Sci, 2023 Oct;30(5):23-39.
PMID: 37928797 DOI: 10.21315/mjms2023.30.5.3

BACKGROUND: Malay medical manuscripts have deciphered the medicinal value of Piper betle (sirih) enormously. In this review, an effort was made to explore the medicinal use of P. betle and correlate this information with the scientific evidence.
METHODS: The information regarding the use of P. betle was retrieved from the books consisting of a Malay medical manuscript with an identification number MSS 2219 from the National Library of Malaysia. PubMed, ScienceDirect and Scopus databases were used to collect information regarding the scientific evidence for the medicinal use of P. betle. This review was written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The keywords used for searching the articles included P. betle, antimicrobial, analgaesic, haepatic and gastric.
RESULTS: MSS 2219 showed that P. betle has varied medicinal uses and based on that, it can be grouped into six categories. P. betle application method was different in different conditions. In terms of the literature search, 226 articles were found, 75 articles were extracted for detailed analysis and only 23 met the inclusion criteria. The information was related to the chemical assays, in vivo and in vitro studies.
CONCLUSION: In summary, P. betle has the potential to treat medical conditions in various types of categories as recorded in the Malay medical manuscripts and also based on scientific publications. For clinical purposes, more information is required, such as the specific mechanism involved, the best extraction method and the best dosage for treatment.
Fulltext A Scoping Review of Intervention Implementation for Self-Care Skills among Children with Developmental Delay

Alias NA, Kadar M, Wan Yunus F, Cremin K

Malays J Med Sci, 2024 Aug;31(4):78-90.
PMID: 39247118 DOI: 10.21315/mjms2024.31.4.6

Difficulties with self-care skills are frequently observed in children with developmental delays. Given the scarcity of robust evidence backing self-care interventions for this group, this scoping review is designed to aggregate existing literature on the implementation of such interventions. Therefore, this scoping review aims to collate literature on the nature of self-care intervention implementation to increase understanding of the current practice and inform future research directions. This scoping review endeavoured to explore the body of literature concerning the existence of self-care interventions and their implementation strategies in children who have developmental delays. Relevant studies were identified by searching through the following databases: Web of Science (W0S), Scopus, ASEAN Citation Index (ACI), CINAHL EBSCO and PubMed. Six types of interventions using various approaches were identified. Occupational therapists mainly manage intervention providers with multidisciplinary co-facilitator and parents' involvement. Whilst session information varied, some evidence suggests that at least 30 min per session, minimum once per week up to twice per week, ranging from 10 to 23 sessions, may be sufficient. Intervention plans should be tailored to each child's unique needs, taking into account the variety of available interventions. Collaboration among occupational therapists, parents, educators and health professionals in home programmes enhances self-care intervention outcomes. These results are set to inform future research and practice, paving the way for enhanced support and improved outcomes for children with developmental delays.
Fulltext A Scoping Review on Cucumis melo and Its Anti-Cancer Properties

Raja Soh RSS, Hapidin H, Kasiram MZ

Malays J Med Sci, 2024 Aug;31(4):63-77.
PMID: 39247112 DOI: 10.21315/mjms2024.31.4.5

Cucumis melo L., better known by its popular cultivar cantaloupe, is an economically significant crop in the Cucurbitaceae family. Melon peel and seeds have shown medicinal potential due to their numerous biological qualities, including anti-inflammatory, anti-cancer, antibacterial, hepatoprotective and immunomodulatory effects to treat cardiovascular disease, diabetes and oedema. This scoping review aims to broaden the research scope on the cancer-fighting abilities of melon extract and its half maximal inhibitory concentration (IC50). Three databases which are Scopus, ScienceDirect and PubMed were used to locate relevant publications utilising the keywords 'melon', 'Cucumis melo', 'inhibitory activity', 'cancer' and 'anti-cancer'. The Preferred Reporting Items for Systematic and Meta-analyses extension for Scoping Review (PRISMA-ScR) framework was used in conducting this study. Out of 904 articles, 14 articles met the inclusion criteria and were used in this analysis. These articles were published in English between 2000 and 2023 with full text accessibility, specifically addressed the fruit cantaloupe (Cucumis melo L.) or melon and reported on any type of cancer. Cucumis melo extract showed promising anti-cancer action in both in vitro and in vivo investigations on eight different cancer types: cervical, colon, prostate, leukaemia, multiple myeloma, breast, hepatoma and ovarian cancer. A thorough analysis shows that some of the IC50 values were significantly low, especially in cases of colon and prostate cancer, indicating a significant anti-cancer effect. The substantial anti-cancer benefits of Cucumis melo fruit extracts point to the necessity for additional investigation into their potential for cancer therapy on each form of cancer.
Fulltext Analysis of Available Nutrition Recommendations to Combat COVID-19: A Scoping Review

Che Abdul Rahim N, Manjit Singh JS, Pardi M, Zainuddin AA, Salleh R

Malays J Med Sci, 2021 Jun;28(3):18-45.
PMID: 34285642 DOI: 10.21315/mjms2021.28.3.3

The current COVID-19 pandemic remains severe. There is no doubt that the COVID-19 pandemic is affecting every aspect of our lives. Currently, the spread of inaccurate information or fake news on the internet to the public is causing the community to panic. Thus, this study aims to obtain available information on food and nutrition related to the prevention and treatment of COVID-19 from various sources. A scoping review framework was used to chart the evidence on nutritional recommendations to prevent COVID-19 based on the preferred method in reporting systematic review and meta-analysis extension for scoping reviews (PRISMA-ScR). The articles were categorised into three main groups: i) general dietary recommendations; ii) supplementation with specific micronutrients and iii) their mixtures and supplementation with traditional herbs and miscellaneous foods. A total of 60 articles met the inclusion criteria and were used in the review. This scoping review demonstrates that there is no miracle cure, food or supplement that can cure or prevent COVID-19. Currently, there is no confirmed treatment or vaccine for the disease. Practicing healthy eating habits is the best nutritional recommendation during the pandemic. Hence, this review hopefully will provide evidence-based nutrition recommendations that are available for current COVID-19 treatment. We hope that the authorities can inform the public and media to stop the spread of nutrition pseudoscience in the wake of the COVID-19 pandemic.
Fulltext Knowledge, Attitudes and Intention to Donate Organs among the Public, Health Sciences Students and Health Personnel: A Scoping Review with a Systematic Review of Malaysian Studies

Saleh EEN, Tan JW, Lim HB, Annamalai O, Sim Chii M, Elhariri S

Malays J Med Sci, 2024 Feb;31(1):181-199.
PMID: 38456104 DOI: 10.21315/mjms2024.31.1.16

BACKGROUND: Various barriers lead to a shortage of organs for transplantation in Malaysia. One drive to improve the organ donation rate operates through future healthcare practitioners and practitioner advocacy. This scoping review was carried out to establish and summarise findings about organ donation-related articles among the public, health sciences students and health personnel. A further aim was to synthesise the latest data on knowledge and attitudes towards organ donation in the Malaysian population.
METHODS: PubMed, Scopus, Google Scholar and the Malaysian Medical Repository (MyMedR) were used for a search conducted up to May 2022. Relevant search terms included 'Organ donation' and 'Malaysia'. Journal articles related to knowledge, attitudes and intention were grouped under the general public and health science. Students and health personnel were included. Eligible studies were reviewed by two independent reviewers. Any disagreements were resolved by consensus with a third reviewer.
RESULTS: The 31 included articles revealed an increased level of awareness among the public regarding organ donation. The analysis identified that nonrecognition of brainstem death (38.5%), no knowledge of how to contact the Organ Transplant Coordinator (82.3%) and never approaching the families of a potential donor (63.9%) led to a lack of confidence among healthcare practitioners to promote organ donation.
CONCLUSION: The shortage of organ donors is the result of the failure to identify the expected donor, obtain consent and procure the organs due to the passivity of Malaysian health professionals in promoting the organ donation process.
Fulltext Factors Affecting Level of Physical Activity among Stroke Survivors: A Scoping Review

Bakhtiar AB, Hanafi MH, Alghwiri A, Manaf H

Malays J Med Sci, 2024 Oct;31(5):115-134.
PMID: 39416741 DOI: 10.21315/mjms2024.31.5.8

Physical activity (PA) is crucial for improving stroke survivors' health outcomes and quality of life (QoL). Impaired PA levels are common among stroke survivors, a significant portion of whom spend their days in sedentary occupations. Understanding the factors that influence physical inactivity and addressing the barriers to exercise participation can contribute significantly to improving stroke survivors' health outcomes and prognoses. Therefore, in the current review, we systematically searched five databases (PubMed/Medline, Scopus, SpringerLink, ScienceDirect and Google Scholar) for published studies reporting PA levels among stroke survivors, which yielded 301 potential articles. Based on the identification and screening processes recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR), 13 articles were finally included in the analysis. The results of these studies, covering 1,318 stroke survivors, revealed physical inactivity among most of the participants and significant heterogeneity among the outcome measures used. The factors affecting PA levels among stroke survivors were mainly categorised as physical, psychological, and sociodemographic, and all were significantly associated with PA levels after strokes.