MyMedR

Fine needle aspiration cytology of the thyroid--a review of experience in 1853 cases

Jayaram G, Razak A, Gan SK, Alhady SF

Malays J Pathol, 1999 Jun;21(1):17-27.

1853 thyroid lesions subjected to cytological sampling (either by the fine needle aspiration or fine needle capillary sampling technique) from January 1992 to December 1997 at the University Hospital, Kuala Lumpur, were reviewed. Nodular goitre was the most common thyroid lesion needled (67.35%). Among the neoplastic lesions, follicular neoplasms predominated (64%), followed by papillary carcinoma (29.4%). In 325 cases, partial or total thyroidectomy had been done, providing material for histological review and cyto-histological correlation. Cytological diagnosis was found to have high sensitivity and specificity rates of over 75%. Besides, most non-neoplastic thyroid lesions could be diagnosed on cytology. The scope of cytology in the diagnosis of lymphomas, anaplastic and metastatic tumours rendered diagnostic biopsies (or thyroidectomy) unnecessary in these cases. Being a cost-effective technique and having the capacity to provide exact morphological diagnosis in a large variety of thyroid lesions, cytology is obviously the method of choice in the assessment of thyroid nodules.

Matched MeSH terms: Thyroid Neoplasms/pathology

Primary squamous cell carcinoma of the thyroid--a case report

Wan Muhaizan WM, Phang KS, Sharifah NA, al Amin D

Malays J Pathol, 1998 Dec;20(2):109-11.

PMID: 10879272

A rare case of primary squamous cell carcinoma of the thyroid is reported herein. A 64-year-old Malay lady presented with a gradually enlarging thyroid nodule for the past 6 months and underwent total thyroidectomy. Histopathology revealed a squamous cell carcinoma of the thyroid with complete resection. Possible primary tumour elsewhere was excluded. Postoperative irradiation was given and patient is still alive after 2 years of follow-up.

Matched MeSH terms: Thyroid Neoplasms/pathology*

Hyalinizing clear cell carcinoma of minor salivary gland: case report

Manoharan M, Othman NH, Samsudin AR

Braz Dent J, 2002;13(1):66-9.

PMID: 11870967

Hyalinizing clear cell carcinoma is a low-grade neoplasm of the minor salivary gland composed exclusively of epithelial cells and not myoepithelial cells. It predominantly affects the oral cavity of adult females. It is microscopically characterized by hyalinizing stroma and clear cells, which are typically positive for cytokeratin markers and negative for S 100 and smooth muscle actin (SMA). Cystic degeneration can also be present. Pathologists should be aware of this new entity so as not to misdiagnose otherwise. To our knowledge, this is the first case report of its kind from Malaysia.

Matched MeSH terms: Salivary Gland Neoplasms/pathology*

Analysis of brain tumours suitable for curability via gene therapy in North East Malaysia

Abdullah J, Isa MN

Stereotact Funct Neurosurg, 1999;73(1-4):19-22.

PMID: 10853092

Two hundred primary brain tumours in both adults and children from the year 1990 to 1998 presenting for treatment to the Neurosurgical Division of the Hospital of the University of Sciences Malaysia were studied retrospectively. Volumes of tumours were taken from CT scans with contrast using two formulas and divided into 4 groups: (1) less than 20 cm(3), (2) 20-50 cm(3), (3) 50-100 cm(3) (4) larger than 100 cm(3). The majority of the brain tumours were in the volume range of 50-100 cm(3), and are thus potentially curable with retroviral gene therapy.

Matched MeSH terms: Brain Neoplasms/pathology

The value of cytology in granulomatous mastitis: a report of 16 cases from Malaysia

Yip CH, Jayaram G, Swain M

Aust N Z J Surg, 2000 Feb;70(2):103-5.

PMID: 10711470

BACKGROUND: Granulomatous mastitis is a rare condition of the breast that can mimic a carcinoma. There are characteristic histological features, the most important of which is a predominantly lobular inflammatory process. It must be differentiated from known causes of granulomatous inflammation, such as tuberculosis.

METHODS: In the present paper, the clinical and pathological features of 16 patients with granulomatous mastitis seen over a 3-year period in the University Hospital, Kuala Lumpur, are described.

RESULTS: A clinical suspicion of malignancy was present in 10 cases. One of the patients was nulliparous. One had an associated hyperprolactinaemia, while two had systemic lupus erythromatosis. One of the patients was pregnant at the time of presentation. Four patients had localized lumps excised, five were treated conservatively because the lesion was too extensive to resect, and seven patients required drainage procedures for abscess formation.

CONCLUSION: Awareness of this condition is important because it mimics a carcinoma, and surgery may not be the best treatment for recurrent disease.

Matched MeSH terms: Breast Neoplasms/pathology

Fulltext Osteosarcoma in a sixteen-month old boy

Ibrahim S, Sundari MN, Masir N

Med J Malaysia, 1999 Jun;54(2):261-3.

PMID: 10972039

We report a case of a sixteen-month old boy with osteosarcoma of the left humerus. To the best of our knowledge this is the youngest case reported in Malaysia. This case illustrates that osteosarcoma although rare does occur in a very young child. The child died six weeks after presentation due to disseminated disease.

Matched MeSH terms: Bone Neoplasms/pathology

Extramammary Paget's disease presenting as condylomata lata

Mohammed KN

Int J STD AIDS, 1993 Jul-Aug;4(4):242-3.

PMID: 8399509

Matched MeSH terms: Anus Neoplasms/pathology*

Fine needle aspiration cytology of secretory carcinoma of breast: a case report

Jayaram G, Looi LM, Yip CH

Malays J Pathol, 1997 Jun;19(1):69-73.

PMID: 10879245

A 39-year-old female presented with a mobile 1.5 cm nodule in the right breast. Fine needle aspiration cytology smears stained with May Grunwald Giemsa were highly cellular with a monotonous population of dissociated and clustered tumour cells that showed a bland cytological appearance with cytoplasmic vacuolation and occasional signet ring forms. Intracellular and extracellular mucus was present. Histological study of the excised breast mass showed a secretory carcinoma. This is a rare breast neoplasm in which cytological features are characteristic enough to permit a specific diagnosis on needle aspirates.

Matched MeSH terms: Breast Neoplasms/pathology*

Four quadrant fine needle aspiration cytology for the detection of benign proliferative breast lesions accompanying breast carcinoma

Jayaram G, Gupta M, Lamba S

Malays J Pathol, 1993 Dec;15(2):137-42.

PMID: 8065175

Forty-eight patients with breast carcinoma were subjected to four quadrant fine needle aspiration (FNA) cytology examination of the ipsilateral and contralateral breast in an attempt to detect any accompanying benign proliferative lesion. Mastectomy of ipsilateral and open biopsy of contralateral breast provided material for histopathological study. Cytological evidence of epithelial proliferation was found in 8 (16.6%) cases which included atypical lobular hyperplasia (ALH), lobular neoplasia in-situ (LNIS), atypical ductal hyperplasia (ADH), and proliferative disease without atypia (PDWA). In lobular proliferative lesions, cytological smears showed configurations of cells that resembled filled up or expanded lobular units. The cytology was not distinctive enough to distinguish the sub-types of lobular proliferations. Likewise, the presence of ductal alterations could be suggested by cytological study but the distinction of proliferative disease without atypia (PDWA) from atypical ductal hyperplasia (ADH) was not possible on a cytological basis.

Matched MeSH terms: Breast Neoplasms/pathology*

Peripheral odontogenic fibroma with clear cell odontogenic epithelium

Siar CH, NG KH

J N Z Soc Periodontol, 1995.

PMID: 9227094

The clinical and histological features of the peripheral odontogenic fibroma are briefly outlined. A case arising from the attached lingual gingiva between the mandibular right permanent first molar and the second molar in a 67 year old Indian female is reported here. The unusual occurrence of marked clear cell differentiation within the odontogenic epithelial component, and histogenetic link to the clear cell rests of the dental lamina and surface epithelium are discussed.

Matched MeSH terms: Gingival Neoplasms/pathology*

Fulltext Massive ovarian cysts--successful management of two cases

Ravindran J

Med J Malaysia, 1994 Sep;49(3):303-5.

PMID: 7845287

Massive ovarian cysts are not commonly encountered. They frequently present a challenge to the gynaecologist who is faced with them. Two cases of successful removal of massive ovarian cysts are presented. Successful management would involve recognition of complications which occur at various steps in the treatment.

Matched MeSH terms: Ovarian Neoplasms/pathology

Lymphoblastic lymphoma/leukaemia presenting as perichondritis of the pinna

Indudharan R, Arni T, Myint KK, Jackson N

J Laryngol Otol, 1998 Jun;112(6):592-4.

PMID: 9764308

Extra-nodal non-Hodgkin's lymphoma (NHL) of the pinna has only been reported once in a patient with immunodeficiency. We report an unusual case of lymphoblastic lymphoma in a patient without any immunodeficiency, presenting as an inflammatory lesion of the pinna, which illustrates the need to biopsy any non-healing lesion as soon as possible to ensure that such a treatable malignancy is diagnosed at an early stage.

Matched MeSH terms: Ear Neoplasms/pathology*

Fulltext Malignant lymphoma of nasal septum--a case report

Amin JM, Merican S, Nazarina AR

Med J Malaysia, 1992 Jun;47(2):147-9.

PMID: 1494335

Malignant lymphoma of nasal septum is uncommon. It presents a problem in diagnosis to both otorhinolaryngologist and pathologist. This case report is about one such patient in whom the local disease has been controlled with the treatment of radiotherapy alone. However it is suggested that combined treatment of radiotherapy and cytotoxic therapy might improve the survival rate.

Matched MeSH terms: Nose Neoplasms/pathology*

Differentiation of elemental composition of normal and malignant breast tissue by instrumental neutron activation analysis

Ng KH, Bradley DA, Looi LM, Mahmood CS, Wood AK

Appl Radiat Isot, 1993 Mar;44(3):511-6.

PMID: 8472024

Multi-elemental quantitative analyses of 15 paired samples of normal and malignant human breast tissue by instrumental neutron activation analysis are reported. The elements, Al, Br, Ca, Cl, Co, Cs, Fe, K, Na, Rb, Zn were detected. Significantly elevated concentration levels were found for Al, Br, Ca, Cl, Cs, K, Na, Zn in malignant compared to normal tissue. Although the role of elemental composition in breast cancer is unclear, this finding may be of importance as another parameter for differentiating normal from malignant tissue.

Matched MeSH terms: Breast Neoplasms/pathology

Fulltext Bilateral pure gonadoblastoma in a 46 XY individual--a case report

Siti Aishah MA, Chandran R, Tahir H

Med J Malaysia, 1991 Dec;46(4):384-7.

PMID: 1840451

We report here a rare case of bilateral pure gonadoblastoma which accounts for only 0.2% of all ovarian tumours seen at Universiti Kebangsaan Malaysia from 1980 to 1987. This tumour occurred in an 18 year old Chinese "female" who presented with primary amenorrhoea. Examination showed a phenotypic female with poorly developed external gentalia. Exploratory laparotomy revealed a hypoplastic uterus, rudimentary fallopian tubes and streak gonads. Histological examination of the gonads showed a mixed tumour comprising large germ cells and smaller sex cord derivatives arranged in characteristic nests or islands containing hyaline material.

Matched MeSH terms: Ovarian Neoplasms/pathology*

Fulltext Oral verrucous carcinoma in peninsular Malaysia

Ramanathan K, Chelvanayagam PI, Ganesan TJ

Med J Malaysia, 1981 Dec;36(4):234-8.

PMID: 7334960

Matched MeSH terms: Mouth Neoplasms/pathology

Desmoplastic fibroma: report of a case with proliferative myositis

Boon LC, Phaik KS, Khanijow V

Ann Dent, 1991;50(2):28-32.

PMID: 1785911

Desmoid tumor of the mandible, or desmoplastic fibroma, is a rare disease with only a few cases reported in the literature. This paper presents the rare case of an elderly male with desmoplastic fibroma of the mandible with an uncommon accompanying proliferative myositis. The case is discussed with emphasis on the clinical presentation, differential diagnosis and treatment of this lesion.

Matched MeSH terms: Mandibular Neoplasms/pathology*

Fulltext Primary adenocarcinoma of the fallopian tube--a case report

Tharmaseelan NK, Sundralingam S

Med J Malaysia, 1989 Dec;44(4):354-6.

PMID: 2520049

Adenocarcinoma of the fallopian tube is a rare clinical entity. The incidence of primary tubal carcinoma has been reported as varying from 0.1 to 1.0 percent of all gynaecological malignancies. In Malaysia the incidence is unknown. A case of primary adenocarcinoma of the fallopian tube is reported.

Matched MeSH terms: Fallopian Tube Neoplasms/pathology*

Torsion of ovarian tumors: a clinicopathological study

Lee CH, Raman S, Sivanesaratnam V

Int J Gynaecol Obstet, 1989 Jan;28(1):21-5.

PMID: 2565826

Torsion of ovarian tumors occurred predominantly in the reproductive age group. The majority of the cases presented in pregnant (22.7%) than in non-pregnant (6.1%) women. The major presenting symptom was pain but an abdominal mass was palpable in 79.4% of cases. Torsion was more common on the right ovary and 50% were gangrenous at laparotomy. Most of the tumors were benign cystic teratomas. Only 8.7% of the tumors were malignant.

Matched MeSH terms: Ovarian Neoplasms/pathology*

Fulltext Traumatic neuroma in wall of recurrent unicystic ameloblastoma: a case report

Zain R, Ling KC

Med J Malaysia, 1985 Mar;40(1):49-51.

PMID: 3831736

This is a case report of a recurrent lesion diagnosed histologically as a unicystic ameloblastoma. The concomitant presence of a traumatic neuroma was observed within the wall of the recurrent lesion. The mode of development of the traumatic neuroma, and the reason for the recurrence were presented.

Matched MeSH terms: Mandibular Neoplasms/pathology*

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