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  1. Hasan NH, Ignjatovic J, Peaston A, Hemmatzadeh F
    Viral Immunol, 2016 05;29(4):198-211.
    PMID: 26900835 DOI: 10.1089/vim.2015.0127
    Vaccination is becoming a more acceptable option in the effort to eradicate avian influenza viruses (AIV) from commercial poultry, especially in countries where AIV is endemic. The main concern surrounding this option has been the inability of the conventional serological tests to differentiate antibodies produced due to vaccination from antibodies produced in response to virus infection. In attempts to address this issue, at least six strategies have been formulated, aiming to differentiate infected from vaccinated animals (DIVA), namely (i) sentinel birds, (ii) subunit vaccine, (iii) heterologous neuraminidase (NA), (iv) nonstructural 1 (NS1) protein, (v) matrix 2 ectodomain (M2e) protein, and (vi) haemagglutinin subunit 2 (HA2) glycoprotein. This short review briefly discusses the strengths and limitations of these DIVA strategies, together with the feasibility and practicality of the options as a part of the surveillance program directed toward the eventual eradication of AIV from poultry in countries where highly pathogenic avian influenza is endemic.
  2. Wong M, Woolford L, Hasan NH, Hemmatzadeh F
    Viral Immunol, 2017 05;30(4):258-263.
    PMID: 28426340 DOI: 10.1089/vim.2016.0041
    In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centrilobular to panlobular necrohemorrhagic hepatitis and the development of disseminated intravascular coagulation in the terminal stages of disease. Comparison of partial genome sequences revealed that although these newly detected viruses mainly had CAdV-1 genome characteristics, their pVIII gene was more similar to that of CAdV-2. This likely suggests that a recombination has occurred between CAdV-1 and CAdV-2, which possibly explains the cause of vaccine failure or increased virulence of the virus in the observed ICH cases.
  3. Hasan NH, Ebrahimie E, Ignjatovic J, Tarigan S, Peaston A, Hemmatzadeh F
    PLoS One, 2016;11(6):e0156418.
    PMID: 27362795 DOI: 10.1371/journal.pone.0156418
    A common approach for developing diagnostic tests for influenza virus detection is the use of mouse or rabbit monoclonal and/or polyclonal antibodies against a target antigen of the virus. However, comparative mapping of the target antigen using antibodies from different animal sources has not been evaluated before. This is important because identification of antigenic determinants of the target antigen in different species plays a central role to ensure the efficiency of a diagnostic test, such as competitive ELISA or immunohistochemistry-based tests. Interest in the matrix 2 ectodomain (M2e) protein of avian influenza virus (AIV) as a candidate for a universal vaccine and also as a marker for detection of virus infection in vaccinated animals (DIVA) is the rationale for the selection of this protein for comparative mapping evaluation. This study aimed to map the epitopes of the M2e protein of avian influenza virus H5N1 using chicken, mouse and rabbit monoclonal or monospecific antibodies. Our findings revealed that rabbit antibodies (rAbs) recognized epitope 6EVETPTRN13 of the M2e, located at the N-terminal of the protein, while mouse (mAb) and chicken antibodies (cAbs) recognized epitope 10PTRNEWECK18, located at the centre region of the protein. The findings highlighted the difference between the M2e antigenic determinants recognized by different species that emphasized the importance of comparative mapping of antibody reactivity from different animals to the same antigen, especially in the case of multi-host infectious agents such as influenza. The findings are of importance for antigenic mapping, as well as diagnostic test and vaccine development.
  4. Hasan NH, Daud US, Amat A, Lok YC, Mohd Johar MF, Gompoyo J, et al.
    Biodivers Data J, 2022;10:e87860.
    PMID: 36761649 DOI: 10.3897/BDJ.10.e87860
    A female Hypsugocf.vordermanni was caught at a stream near a village road in Mantailang, Crocker Range Park, Sabah, on 12 November 2018. This bat is a new record for the national park and the second record for Sabah. It was first recorded from Banggi Island, Kudat, in 1991. The species' few records throughout its range is most likely due to sampling effort bias towards forest interior and cave-dwelling species, as this species is more likely an edge-space aerial forager. It is morphologically similar to Peninsular Malaysia's Hypsugomacrotis, but the latter has never been reported from Borneo. Therefore, additional specimen collection and molecular data for H.cf.vordermanni are needed for further species confirmation. More information on H.vordermanni ecology is also crucial in aiding the management plan for this species as it is currently classified as Data Deficient by the IUCN.
  5. Ibrahim NF, Mohamad Sharif S, Saleh H, Mat Hasan NH, Jayiddin NF
    F1000Res, 2023;12:1338.
    PMID: 38152588 DOI: 10.12688/f1000research.141629.1
    Background: The purpose of this research is to examine at how the literature measures the relationship between PERMA (positive emotion, engagement, relationships, meaning, and accomplishments) well-being and innovative work behaviour (IWB). Methods: This systematic literature review examines peer-reviewed English research papers published in 2012 that investigate the relationship between PERMA well-being and IWB. A total of 37 publications were discovered in 32 journals. Results: A total of 220 articles were initially retrieved from the database. 37 studies out of 220 satisfied the inclusion criteria and were thoroughly examined. Our findings present a comprehensive overview of the types of PERMA well-being related to IWB in different countries and industries. Literature-based research approaches are also discussed. Research methods from the previous literature are also discussed. Conclusions: This study is one of the first to conduct a systematic literature review (PRISMA) method on the relationship between PERMA well-being and IWB. This review suggests constructive future research directions.
  6. Hasegawa H, Frias L, Peter S, Hasan NH, Stark DJ, Lynn MS, et al.
    Zootaxa, 2020 Jan 14;4722(3):zootaxa.4722.3.6.
    PMID: 32230627 DOI: 10.11646/zootaxa.4722.3.6
    Males of Enterobius (Colobenterobius) serratus Hasegawa et al., 2003 (Nematoda: Oxyuridae) are described for the first time based on six individuals collected from the feces of proboscis monkeys, Nasalis larvatus, in the Lower Kinabatangan Wildlife Sanctuary, Sabah, Malaysian Borneo. The males show identical cephalic morphology to females, being readily distinguishable from their congeners by the serrated inner margins of the lips. The bicolored esophageal corpus, long thin spicule and developed spicular pouch with paired muscular bands are also remarkable characteristics, presumably shared by other Asian members of the subgenus.
  7. Lok YC, Siau VG, Mohd Kanapiah NAA, Lai TC, Haslan NNHH, Nukili NN, et al.
    Biodivers Data J, 2021;9:e72651.
    PMID: 34803464 DOI: 10.3897/BDJ.9.e72651
    Bats (Order: Chiroptera) is a recognised group of bioindicators due to their sensitivity towards alterations in their immediate surroundings. With the threats of climate change becoming more severe on a daily basis, it is reasonable to collect data on how bat diversity is influenced by elevation. This will be useful to predict and monitor possible upslope shifting of bat species due to increase in surrounding temperature or anthropogenic pressure. Hence, this study aims to uncover the bat diversity trend at different elevations in Crocker Range Park (CRP), Sabah, Malaysia. Bat trappings were conducted in four substations within this park, covering an elevation spectrum from 450 to 1900 m a.s.l. The overall sampling managed to capture 133 individuals of bats, predominantly Pteropodidae, with the addition of two new species locality records for CRP, Murinapeninsularis and Hypsugovondermanni. Simple linear regression analyses revealed that both bat diversity and richness have an inverse linear relationship with elevation. Likewise, the Pearson's correlation value, associating bat diversity with elevation, also shows that they have a negative relationship at r = -0.852. Heterogeneity of habitats explain this trend, as in the lower counterpart of CRP, lowland forests, which are richer in fruit and insect resources persist. Besides, lower land forests have better niche assortment, due to the distinctive layers stratification, allowing bats utilising different guilds to thrive in the same vegetation profile. This study further emphasises the role of CRP to protect most of the bat species found in Borneo, as well as serving as the baseline data for the future studies that look into the impact of temperature increment towards the upslope shifting of the bat population in CRP.
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