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Fulltext Loneliness among elderly in community residence at Pontian District, Johore

Rohani Mamat, Hussein S Z, Shamsudin K

Malaysian Journal of Medicine and Health Sciences, 2020;16(105):44-0.
MyJurnal

Introduction: Loneliness is a major social problem among the elderly that has gone through almost all countries in the world. Even though loneliness is seen as the health-threatening but, the loneliness assessment is still marginal- ized in routine medical check-up for every senior citizen. Methods: This is a sequential explanatory mixed-method study with a cross-sectional community survey was conducted among 380 community residence elderly followed by in-depth interview among eight respondents. This study aims to measure the loneliness and to explore loneliness experienced by older adults. Data were collected using the short form of Social and Emotional Loneliness Scale for Adults (SELSA-S) and data were analysed using SPSS (version 23.0) for windows. In the qualitative study, eight re- spondents were interviewed face-to-face and data were analysed using thematic analysis Braun and Clarke (2006). Results: The results revealed that 37.2% of respondents had loneliness. Bivariate analyses showed the age, level of education and marital status were significantly associated with loneliness. The results of multiple logistic regression discovered gender (OR=1.75,95%CI:1.04-2.93; p=0.03) and marital status (OR=2.24,95%CI: 1.33-3.77;p= 0.002) were a significant predictor of loneliness. In a qualitative study, the result showed two main themes were recorded as causes of loneliness among the elderly are ‘changing the lifestyles’ and ‘ineffective communications. The sub-themes included ‘loss of someone who significant’, ‘limited physical mobility’, ‘all alone’ and ‘no support’. Conclusion: The issue of loneliness needs critically to be addressed even though Malaysia has not reached the ‘aging population’, but the loneliness prevalence experienced by the older adult has similarities with other countries that have attained that status.
Fulltext The modified Gompertz model demonstrates a variable growth rate between two Centella asiatica phenotypes

Hussein, S., Halmi, M.I.E., Ling, A.P.K.

Journal of Biochemistry, Microbiology and Biotechnology, 2017;5(1):18-20.
MyJurnal

Centella asiatica, a weakly aromatic plant that flourishes in wet tropical and sub-tropical areas as
a medicinal species since ancient times. It contained important terpenoids that impart important
medicinal values. Currently, studies on the terpenoid content of various Centella asiatica
phenotypes have shown not only variable content but variable growth rates of different
phenotypes that can affect future selection of phenotypes. The use of mathematical growth
modelling can reveal important growth constants and discriminate between faster and slower
growth phenotypes. Two Centella asiatica phenotypes from South Africa is modelled using the
modified Gompertz model and the results showed that the C. asiatica Type-1 exhibited a faster
growth rates and a shorter lag period at 0.152 day-1 and 2.313 day than another phenotype; C.
asiatica Type 2 with a growth rate and a lag period of 0.067 day-1 and 3.363 day, respectively.
The data indicates that different phenotypes of C. asiatica can have different growth rates and
lag period and this can be important for selection of phenotypes to be used as the best bioactive
peptides producer.
Fulltext Modelling the growth kinetics of callus cultures from the seedling of Jatropha curcas L. according to the modified Gompertz model

Hussein, S., Halmi, M.I.E., Ling, A.P.K.

Journal of Biochemistry, Microbiology and Biotechnology, 2016;4(1):20-23.
MyJurnal

One of the most important preliminary investigation of callus attributes is the growth
characteristics. Most often than not, callus growth curve is sigmoidal in characteristics. In this
work, we model callus growth from the seedling of Jatropha curcas L. according to the
modified Gompertz model from published literature to acquire essential growth constants.
These growth constants can be obtained with better precision using model such as the modified
Gompertz. Parameters obtained from the fitting exercise were maximum callus growth rate
(μm), lag time (l) and maximal callus production (Ymax) of 0.193 d-1, 2.91 days and 0.38 g
callus/25 mL culture, respectively. Growth parameter constants extracted from the modelling
exercise will be helpful for additional secondary modelling implicating the consequence of
media conditions as well as other factors on the growth of callus from this plant.
Fulltext Modelling the effect of 2-4, D on the growth kinetics of cell suspension cultures of Ficus deltoidea L

Ling, A.P.K., Halmi, M.I.E., Hussein, S., Ong S.L.

Journal of Biochemistry, Microbiology and Biotechnology, 2015;3(2):1-5.
MyJurnal

The mistletoe fig (Ficus deltoidea) is frequently found in several areas of the world, and primarily functions as houseplant or an ornamental shrub. The plant is discovered indigenous generally in Asia tropical region for example Indonesia, Philippines, Malaysia, and Thailand. Scientific studies on the effect of plant growth regulators on cells production from this plant are vital as optimization of cells production may result in effective production of secondary products characterization and output. The growth of cell suspension cultures from this plant shows sigmoidal property. In this work, we model the effect of the plant growth regulator 2,4-dichlorophenoxyacetic acid (2,4-D) on the growth kinetics of the cells from this plant according to the modified Gompertz model. The coefficient of determination showed good agreement between experimental and predicted data with values ranging from 0.97-0.98. The results showed that 2,4-D at 2 mg/L was optimal for achieving the highest cells growth rate. It is anticipated that the growth parameter constants extracted from the modelling exercise will be helpful in the future for additional secondary modelling on the effect of media conditions as well as other factors on cells growth.
Fulltext Modelling the effect of picloram on the growth kinetics of cell suspension cultures of Ficus deltoidea L.

Ling, A.P.K., Halmi, M.I.E., Hussein, S., Ong, S.L.

Journal of Biochemistry, Microbiology and Biotechnology, 2016;4(1):24-28.
MyJurnal

Ficus deltoidea (or commonly known as mistletoe fig) in various parts of the world mainly
serves as an ornamental shrub or houseplant and found native mainly in Asia tropical region,
for example, Malaysia, Indonesia, Philippines and Thailand. Studies on the effect of plant
growth regulators on cells production from this plant is important as optimization of cells
production can lead to efficient production of secondary products characterization and
production. An important aspect of the sigmoidal cells growth curve is the growth parameters.
In this work, we model the effect of picloram (4-amino-3,5,6-trichloropicolinic acid) on the
growth kinetics of the cell suspension cultures of Ficus deltoidea according to the modified
Gompertz model. The adjusted coefficient of determination showed good agreement between
experimental and predicted data with values ranging from 0.97-0.99. Parameters obtained from
the fitting exercise were maximum cells growth rate (μm), lag time (l) and maximal cells
production (Ymax). The results showed that picloram at concentrations of 3 mg/L and above
were optimal for giving the highest cells growth rate measured as PCV (packed cell volume).
The parameter growth rate obtained from the modelling exercise will be helpful for additional
secondary modelling implicating the consequence of media conditions as well as other factors
on the effect of picloram on the growth rate of cell suspension from this plant.
Fulltext Malaysian Psoriasis Registry--preliminary report of a pilot study using a newly revised registry form

Chang CC, Gangaram HB, Hussein SH

Med J Malaysia, 2008 Sep;63 Suppl C:68-71.
PMID: 19227676

The Malaysian Psoriasis Registry, established in 1998, is the first skin disease clinical registry in Malaysia. It aims to provide useful data on various aspects of psoriasis. Following an extensive revision of the registry form in 2007, a total of 509 psoriasis patients from 10 government dermatologic centres were reviewed in a three month pilot study. The onset of psoriasis was during the second to fourth decade of life in the majority of patients. There was no sexual and ethnic predilection. A positive family history was present in 21.2%, and more common in patients with younger disease onset. The main aggravating factors of psoriasis were stress, sunlight and infection. Plaque psoriasis was the commonest clinical type (80.9%). Joint disease was present in 17.3% of patients, among which mono-/oligoarticular type being the commonest. Nail changes occurred in 68%. More psoriasis patients were overweight and obese compared to the normal population. The mean Dermatologic Life Quality Index (DLQI) score was 8.08 +/- 6.29, and changes during subsequent follow-up may reflect therapeutic effectiveness. This study enabled evaluation of the revised registry form and helped in identifying shortcomings in the implementation of the registry.
Fulltext A novel therapy for the treatment of pyoderma gangrenosum

Azizan NZ, Gangaram HB, Hussein SH

Med J Malaysia, 2008 Mar;63(1):51-4.
PMID: 18935734 MyJurnal

Pyoderma gangrenosum (PG) is an uncommon, chronic, painful, ulcerative skin disease of unknown origin, often associated with systemic diseases including inflammatory bowel disease, rheumatoid arthritis; monoclonal gammopathy, hepatitis and myeloproliferative disorders. The mainstay of therapy for PG has been high-dose corticosteroids but not all patients have a favourable outcome. Other systemic agents have also been used such as cyclosporine, azathioprine, cyclophosphamide and tacrolimus. However, all these systemic therapies can be complicated by serious side effects. In this paper, we report a series of four patients with pyoderma gangrenosum treated successfully with topical cyclosporine. No side-effects were observed in any of the patients and there was minimal systemic absorption of the topical cyclosporine.
Fulltext Comparative effects of plant growth regulators on leaf and stem explants of Labisia pumila var. alata

Ling AP, Tan KP, Hussein S

J Zhejiang Univ Sci B, 2013 Jul;14(7):621-31.
PMID: 23825148 DOI: 10.1631/jzus.B1200135

OBJECTIVE: Labisia pumila var. alata, commonly known as 'Kacip Fatimah' or 'Selusuh Fatimah' in Southeast Asia, is traditionally used by members of the Malay community because of its post-partum medicinal properties. Its various pharmaceutical applications cause an excessive harvesting and lead to serious shortage in natural habitat. Thus, this in vitro propagation study investigated the effects of different plant growth regulators (PGRs) on in vitro leaf and stem explants of L. pumila.
METHODS: The capabilities of callus, shoot, and root formation were evaluated by culturing both explants on Murashige and Skoog (MS) medium supplemented with various PGRs at the concentrations of 0, 1, 3, 5, and 7 mg/L.
RESULTS: Medium supplemented with 3 mg/L indole-3-butyric acid (IBA) showed the optimal callogenesis from both leaf and stem explants with (72.34 ± 19.55)% and (70.40 ± 14.14)% efficacy, respectively. IBA was also found to be the most efficient PGR for root induction. A total of (50.00 ± 7.07)% and (77.78 ± 16.47)% of root formation were obtained from the in vitro stem and leaf explants after being cultured for (26.5 ± 5.0) and (30.0 ± 8.5) d in the medium supplemented with 1 and 3 mg/L of IBA, respectively. Shoot formation was only observed in stem explant, with the maximum percentage of formation ((100.00 ± 0.00)%) that was obtained in 1 mg/L zeatin after (11.0 ± 2.8) d of culture.
CONCLUSIONS: Callus, roots, and shoots can be induced from in vitro leaf and stem explants of L. pumila through the manipulation of types and concentrations of PGRs.
Does gamma irradiation affect physicochemical properties of honey?

Hussein SZ, Yusoff KM, Makpol S, Mohd Yusof YA

Clin Ter, 2014;165(2):e125-33.
PMID: 24770820 DOI: 10.7471/CT.2014.1695

Honey is a supersaturated solution of sugars, enriched with proteins, minerals, vitamins, organic acids and polyphenols. Gamma irradiation is a physical technique of food preservation which protects the honey from insects' and microbial contamination during storage. We investigated the effect of gamma irradiation on physicochemical properties in two types of Malaysian honey, Gelam and Nenas.
Computerised image analysis of vitiligo lesion: evaluation using manually defined lesion areas

Nugroho H, Ahmad Fadzil MH, Shamsudin N, Hussein SH

Skin Res Technol, 2013 Feb;19(1):e72-7.
PMID: 22233154 DOI: 10.1111/j.1600-0846.2011.00610.x

Vitiligo is a cutaneous pigmentary disorder characterized by depigmented macules and patches that result from loss of epidermal melanocytes. Physician evaluates the efficacy of treatment by comparing the extent of vitiligo lesions before and after treatment based on the overall visual impression of the treatment response. This method is called the physician's global assessment (PGA) which is subjective. In this article, we present an innovative digital image processing method to determine vitiligo lesion area in an objective manner.
Fulltext Cutaneous vasculitis: a review of aetiology and clinical manifestations in 85 patients in Malaysia

Muthupalaniappen L, Aziz SA, Gangaram HB, Hussein SH

Med J Malaysia, 2009 Sep;64(3):210-2.
PMID: 20527269 MyJurnal

Cutaneous vasculitis presents with a variety of clinical morphologies and causes significant morbidity. A total of 85 patients with cutaneous vasculitis at Hospital Kuala Lumpur were retrospectively reviewed. Palpable purpura was seen in 49.4% and frequently involved the lower limbs (50.6%). Identifiable causes include drugs (28.2%), infections (20.0%) and connective tissue disorders (16.5%). Non steroidal antiinflammatory were the commonest group of drugs responsible for 25% of cases while B-haemolytic streptococci was the leading infectious cause (64.7%).
Objective assessment of psoriasis erythema for PASI scoring

Ahmad Fadzil MH, Ihtatho D, Mohd Affandi A, Hussein SH

J Med Eng Technol, 2009;33(7):516-24.
PMID: 19639508 DOI: 10.1080/07434610902744074

Skin colour is vital information in dermatological diagnosis as it reflects the pathological condition beneath the skin. It is commonly used to indicate the extent of diseases such as psoriasis, which is indicated by the appearance of red plaques. Although there is no cure for psoriasis, there are many treatment modalities to help control the disease. To evaluate treatment efficacy, the current gold standard method, PASI (Psoriasis Area and Severity Index), is used to determine severity of psoriasis lesion. Erythema (redness) is one parameter in PASI and this condition is assessed visually, thus leading to subjective and inconsistent results. Current methods or instruments that assess erythema have limitations, such as being able to measure erythema well for low pigmented skin (fair skin) but not for highly pigmented skin (dark skin) or vice versa. In this work, we proposed an objective assessment of psoriasis erythema for PASI scoring for different (low to highly pigmented) skin types. The colour of psoriasis lesions are initially obtained by using a chromameter giving the values L*, a*, and b* of CIELAB colour space. The L* value is used to classify skin into three categories: low, medium and highly pigmented skin. The lightness difference (DeltaL*), hue difference (Deltah(ab)), chroma (DeltaC*(ab)) between lesions and the surrounding normal skin are calculated and analysed. It is found that the erythema score of a lesion can be distinguished by their Deltah(ab) value within a particular skin type group. References of lesion with different scores are obtained from the selected lesions by two dermatologists. Results based on 38 lesions from 22 patients with various level of skin pigmentation show that PASI erythema score for different skin types i.e. low (fair skin) to highly pigmented (dark skin) skin types can be determined objectively and consistent with dermatology scoring.
Area assessment of psoriasis lesions for PASI scoring

Fadzil MH, Ihtatho D, Affandi AM, Hussein SH

J Med Eng Technol, 2009;33(6):426-36.
PMID: 19557605 DOI: 10.1080/07434610902744066

Psoriasis is a skin disorder which is caused by a genetic fault. Although there is no cure for psoriasis, there are many treatment modalities to help control the disease. To evaluate treatment efficacy, the current gold standard method, PASI (Psoriasis Area and Severity Index), is used to measure psoriasis severity by evaluating the area, erythema, scaliness and thickness of the plaques. However, the determination of PASI can be tedious and subjective. In this work, we develop a computer vision method that determines one of the PASI parameters, the lesion area. The method isolates healthy and healed skin areas from lesion areas by analysing the hue and chroma information in the CIE L*a*b* colour space. Centroids of healthy skin and psoriasis in the hue-chroma space are determined from selected sample. The Euclidean distance of all pixels from each centroid is calculated. Pixels are assigned to either healthy skin or psorasis lesion classes based on the minimum Euclidean distance. The study involves patients from different ethnic origins having three different skin tones. Results obtained show that the proposed method is able to determine lesion areas with accuracy higher than 90% for 28 out of 30 cases.

Study site: Dermatology Clinic, Hospital Kuala Lumpur
Area assessment of psoriasis lesion for PASI scoring

Ihtatho D, Fadzil MH, Affandi AM, Hussein SH

Annu Int Conf IEEE Eng Med Biol Soc, 2007;2007:3446-9.
PMID: 18002738

Psoriasis is a skin disorder which is caused by genetic fault. There is no cure for psoriasis, however, there are many treatment modalities to help control the disease. To evaluate treatment efficacy, PASI (Psoriasis Area and Severity Index) which is the current gold standard method is used to measure psoriasis severity by evaluating the area, erythema, scaliness and thickness of the plaques. However, the calculation of PASI can be tedious and subjective. In this work, we develop a computer vision method that determines one of the PASI parameter, the lesion area. The method isolates healthy (or healed) skin areas from lesion areas by analyzing the hue and chroma information in the CIE L*a*b* colour space. Centroids of healthy skin and psoriasis in the hue-chroma space are determined from selected sample. Euclidean distance of all pixels from each centroid is calculated. Each pixel is assigned to the class with minimum Euclidean distance. The study involves patients from three different ethnic origins having different skin tones. Results obtained show that the proposed method is comparable to the dermatologist visual approach.
Fulltext Subcutaneous panniculitic T-cell lymphoma-review of five cases

Ng TG, Ayadurai K, Gangaram HB, Hussein SH

Med J Malaysia, 2006 Dec;61(5):586-91.
PMID: 17623960 MyJurnal

Subcutaneous panniculitic T-cell lymphoma (SPTL) is a rare variant of cutaneous T-cell lymphoma where lymphoma cells infiltrate preferentially into subcutaneous tissue. Five cases of SPTL were seen during the period from 2001-2004 at the Department of Dermatology, Hospital Kuala Lumpur. All five presented with multiple subcutaneous nodules on the face, trunk and limbs of one week to six months duration with associated fever and loss of weight. Physical examination showed multiple tender, erythematous indurated plaques and subcutaneous nodules on their face, trunk and limbs. One patient also presented with unhealing ulcerated nodules. Two patients had hepatosplenomegaly and one hepatomegaly. Two patients had pancytopaenia while the other three had leucopaenia. One patient had deranged liver function. Out of the five patients, three had bone marrow examination with haemophaegocytosis in two and one hypocellular marrow. Skin biopsy of all patients showed infiltration with atypical lymphoid cells in the upper dermis and subcutaneous fat. These neoplastic cells showed positivity for CD3 and CD30 in three patients with CD8, TIA-1 and LCA (Leucocyte common antigen) being positive in one patient. One patient treated with prednisolone and subcutaneous Roferon 3Mu three times a week since 2001 was in remission. Two patients who were planned for chemotherapy had deteriorated rapidly and succumbed to septicaemia from pancytopaenia. Subcutaneous panniculitic T-cell lymphoma has been reported to show two distinct clinical presentations. The first is characterized by an indolent course with good prognosis and the second with rapid clinical deterioration, haemophaegocytosis and death. Both presentations were seen in our five patients seem to demonstrate these two subtypes of SPTL.
Chronic mucocutaneous candidiasis with deficient CD2 (E receptor) but normal CD3 mononuclear cells

Noh LM, Hussein SH, Sukumaran KD, Rose I, Abdullah N

J Clin Lab Immunol, 1991 Jun;35(2):89-93.
PMID: 1688166

A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated alternative pathway resulting in immunodeficiency. Such abnormal CD2-/CD3+ subpopulations have been described in lepromatous leprosy and foetal abortuses.
Fulltext A case of erythropoietic protoporphyria

Ch'ng SL, Gangaram HB, Hussein SH, Rajagopalan K

Med J Malaysia, 1988 Sep;43(3):243-5.
PMID: 3241583
Objective assessment of psoriasis erythema for PASI scoring

Ahmad Fadzil MH, Ihtatho D, Affandi AM, Hussein SH

Annu Int Conf IEEE Eng Med Biol Soc, 2008;2008:4070-3.
PMID: 19163606 DOI: 10.1109/IEMBS.2008.4650103

Skin colour is vital information in dermatological diagnosis. It reflects pathological condition beneath the skin and commonly being used to indicate the extent of a disease. Psoriasis is a skin disease which is indicated by the appearance of red plaques. Although there is no cure for psoriasis, there are many treatment modalities to help control the disease. To evaluate treatment efficacy, PASI (Psoriasis Area and Severity Index) which is the current gold standard method is used to determine severity of psoriasis lesion. Erythema (redness) is one parameter in PASI. Commonly, the erythema is assessed visually, thus leading to subjective and inconsistent result. In this work, we proposed an objective assessment of psoriasis erythema for PASI scoring. The colour of psoriasis lesion is analyzed by DeltaL, Deltahue, and Deltachroma of CIELAB colour space. References of lesion with different scores are obtained from the selected lesions by two dermatologists. Results based on 38 lesions from 22 patients with various level of skin pigmentation show that PASI erythema score can be determined objectively and consistent with dermatology scoring.
Single dose kinetic study of the triple combination mefloquine/sulphadoxine/pyrimethamine (Fansimef) in healthy male volunteers

Mansor SM, Navaratnam V, Mohamad M, Hussein S, Kumar A, Jamaludin A, et al.

Br J Clin Pharmacol, 1989 Mar;27(3):381-6.
PMID: 2785812

A single dose pharmacokinetic study of a combined antimalarial formulation of mefloquine, sulphadoxine and pyrimethamine (Fansimef) has been performed in 10 healthy adult male Malaysian volunteers. The dose consisted of two tablets containing 250 mg mefloquine base, 500 mg sulphadoxine base and 25 mg pyrimethamine base each. Plasma concentrations of mefloquine and pyrimethamine were measured by GC-ECD, those of sulphadoxine by h.p.l.c. Time to peak concentrations (mean +/- s.d. for mefloquine (5.70 +/- 0.95 h), sulphadoxine (3.75 +/- 2.03 h) and pyrimethamine (3.30 +/- 1.98 h) were similar to those observed by others after administration of the single compounds. This was also true for elimination half-lives (t1/2). The t1/2s for mefloquine, sulphadoxine and pyrimethamine were 387 +/- 98 h, 255 +/- 61 h and 114 +/- 42 h, respectively.
Fulltext Knowledge and practice of foot care among diabetic elderly in UKM Medical Centre (UKMMC)

Kamaru Zaman NH, Mohd Shah NS, Hussein SZ

The Malaysian Journal of Nursing, 2018;9(3):6-12.
MyJurnal

Diabetes Mellitus has become one of the major and rising diseases affecting population all around the world. The most common complication that rises from the Diabetes Mellitus is diabetic foot ulcer. The increasing rate in diabetic foot ulcer among elderly has become a challenge that continues to rise and worsen. This study is conducted to determine the knowledge and practice of foot care and also the relationship between socio demographic data with knowledge of foot care among diabetic elderly in UKM Medical Centre (UKMMC). This is a quantitative cross-sectional descriptive study. A total of 81 respondents are being participated in this study. More than half of the study participants are female and majority of them are 60-74 years old. The result showed a significant relationship between gender and marital status with the knowledge of foot care among elderly diabetic patient in UKMMC. The present study showed that there was no significantly relationship between age, occupation, monthly income, duration of diabetes, body image and level of education with the knowledge and the level of foot care. In conclusion, the result of this study will help the health organization, hospital, nurses and care giver to take more responsibilities of foot care for diabetic elderly individuals.
Study site: Elderly patients from orthopaedicf emale or male ward, surgical ward, medical ward, orthopaedic clinic and medical clinic, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia

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