MyMedR

Hypersensitivity reaction to dapsone: report from Malaysia

Mohamed KN

Lepr Rev, 1984 Dec;55(4):385-9.

PMID: 6527602

Late yaws and optic atrophy

Mohamed KN

Ann Trop Med Parasitol, 1990 Dec;84(6):637-9.

PMID: 2076042

Fulltext Hailey-Hailey disease--case report

Mohamed KN

Med J Malaysia, 1983 Sep;38(3):188-90.

PMID: 6672559

Hailey-Hailey disease or Chronic Benign Familial Pemphigus is probably rare in this region and to date there is no case report from Malaysia. I report here a Malay patient with this disease but with no family history and who was believed to be suffering from Atopic Eczema for several years. Dapsone effectively controlled the disease in this patient. The clinical features, histology and the therapy are discussed.

Verrucous lesions in children in the tropics

Mohamed KN

Ann Trop Paediatr, 1990;10(3):273-7.

PMID: 1703744

A wide variety of skin disorders in children are encountered by doctors practising in tropical countries. While some of them are common and pose little difficulty in their management, a few are uncommon, run a protracted course and cause errors in diagnosis. Two patients--one with cutaneous tuberculosis and the other with chromomycosis--are described and illustrate the importance of early and prompt detection of disease in children.

Imported yaws in Johor, Malaysia

Mohamed KN

Ann Trop Paediatr, 1988 Dec;8(4):222-4.

PMID: 2467607

Yaws was detected in a six-member family in the southern Malaysia state of Johor. This stresses the need to be vigilant against a long-forgotten disease of childhood which was of great public health concern in the past.

Fulltext Angioimmunoblastic lymphadenopathy--a fulminant case

Mohamed KN

Singapore Med J, 1991 Aug;32(4):276-8.

PMID: 1776012

A 60 year old male presented with pruritus, excoriations and enlargement of several groups of lymph nodes associated with constitutional symptoms following the intake of an aspirin preparation. Lymph node biopsy established the diagnosis of angioimmunoblastic lymphadenopathy. The need to be aware of this condition is highlighted when patients present with clinical features suspicious of lymphoma.

Fulltext Datasets on spatial and temporal distribution of heavy metals concentration in recent sediment at merang river system, Terengganu, Malaysia

Zaini NM, Lee HW, Mohamed KN, Sabuti AA, Suratman S, Ong MC

Data Brief, 2020 Aug;31:105900.

PMID: 32642516 DOI: 10.1016/j.dib.2020.105900

Heavy metal pollution in an aquatic environment has become of the main concern to the world due to their non-biodegradable properties, toxicity, persistence, and their ability to adsorb into food chains. With rapid industrialization and development nowadays, heavy metals are introduced continuously into the estuaries and coastal region through rivers, runoff, and land-based point sources. These heavy metals may degrade the aquatic environment and harm the living organisms and toward human indirection through secondary contact. The dataset provided is to give an overview of the spatial and temporal distribution of the heavy metals concentration in Merang River surficial sediment collected from September 2017 to July 2018, subsequently every two months dataset. Sediment samples were collected in 44 stations along the river and 20 stations in the coastal area, which total up to 64 stations. Teflon Bomb closed digestion method with mixed acid was used to digest the sediments. The concentration of heavy metals in the sediment were analysed by using Inductively Coupled Plasma Mass Spectrometer (ICP-MS). The spatial distribution of heavy metals shows the effect of monsoon and wet and dry seasons in the sampling area. Thus, this dataset reveals six months of information on natural and anthropogenic sources intrusion at the Merang River and may also help in monitoring the pollution in the area.

Fulltext Impact of Diuron contamination on blood cockles (Tegillarca granosa Linnaeus, 1758)

Mohamat-Yusuff F, Zulkarnain Z, Anuar NZA, Joni AAM, Kusin FM, Mohamed KN, et al.

Mar Pollut Bull, 2020 Dec;161(Pt A):111698.

PMID: 33022498 DOI: 10.1016/j.marpolbul.2020.111698

Examination of the impact of Diuron contamination on blood cockles (Tegillarca granosa) was conducted by combining field screening at three sampling events and a toxicity test. Diuron was extracted using the liquid-liquid extraction (LLE) technique and analyzed using HPLC-UV. The median lethal concentration (LC50) of Diuron on T. granosa was tested under a 72-h exposure. Diuron in water samples ranged from not detected (ND) to 3910 ppb, which was the highest concentration detected in samples after the irrigation water was discharged from the paddy plantation. Diuron was not detected in sediment samples. Mortality of T. granosa ranged from 4.74 to 38.33% with the highest percentages recorded after the release of the irrigation water. The LC50 value of Diuron was 1.84 ppm. This study suggests that irrigation water from paddy plantation that drifts to coastal areas containing Diuron harms T. granosa at the study area.

Development and evaluation of a sustainable video health education program for newly diagnosed breast cancer patients in Malaysia

Islam T, Musthaffa S, Hoong SM, Filza J, Jamaris S, Cheng ML, et al.

Support Care Cancer, 2021 May;29(5):2631-2638.

PMID: 32968861 DOI: 10.1007/s00520-020-05776-4

PURPOSE: Wider breast cancer (BC) treatment options, short consultation time with physicians, lack of knowledge, and poor coping skills at the time of diagnosis may affect patients' decisions causing treatment delays and non-adherence. To address this gap, a breast care nurse video orientation program was started. Our aim was to evaluate the video on patients' knowledge, satisfaction, and treatment adherence.

METHODS: The video was developed using the BC delay explanatory model. A self-administered pre- and post-survey on 241 newly diagnosed BC patients in University Malaya Medical Center was performed. The Wilcoxon matched paired signed rank test was used to evaluate patients' pre and post perceived knowledge using a Likert scale 0 to 4 (0 = "no knowledge," 4 = "a great degree of knowledge"). Treatment adherence among participants were measured after 1-year follow-up.

RESULTS: Eighty percent of the patients reported that the video met or exceeded their expectations. In total 80.5% reported that the video was very effective and effective in improving their perspective on BC treatments. There was improvement in perceived knowledge for treatment options (mean scores; M = 0.93 versus M = 2.97) (p < 0.001) and also for perceived knowledge on types of operation, information on chemotherapy, radiotherapy, hormone therapy, healthy diet, physical activity after treatments, and care of the arm after operation(p < 0.001). In total 89.4%, 79.3%, and 85.9% adhered to surgical, chemotherapy, and radiotherapy recommended treatment, respectively.

CONCLUSION: The video improved patients' perceived knowledge and satisfaction. The program improved access not only to new BC patients but also the public and found sustainable using the YouTube platform.

Baseline distribution and sources of selected agricultural runoff in the bottom water of an active cockle farming area, Bagan Pasir, Perak, Malaysia

Joni AAM, Mohamat-Yusuff F, Noor NAM, Mohamed KN, Ash'aari ZH, Kusin FM, et al.

Mar Pollut Bull, 2021 Jun;167:112276.

PMID: 33901978 DOI: 10.1016/j.marpolbul.2021.112276

This paper aims to study the spatial and temporal patterns of selected agricultural runoff, specifically in terms of glyphosate, nitrate, and ammonia in bottom water, as well as their possible sources, within an active cockle farming area in Bagan Pasir, Perak, Malaysia. Samples were taken along the cockle farming area from March to November 2019. Glyphosate was analyzed using HPLC with both extraction and derivatization methods using 9-fluorenyl-methyl chloroformate (FMOC-Cl), while nitrate and ammonia levels were determined using the standard Hach method. Generally, glyphosate, nitrate, and ammonia were present within the study site with the average concentration of 37.44 ± 12.27 μg/l, 1.65 ± 0.52 mg/l, and 0.37 ± 0.19 mg/l, respectively. The results suggest that glyphosate and nitrate might be derived from an inland source, while a uniform and low level of ammonia suggested might originate from lithogenic origins. Continuous monitoring remains encouraged.

Toxicity effect of Diuron on gill tissue structure and the tissue residue of blood cockles (Tegillarca granosa)

Mohamat-Yusuff F, Ibrahim DSM, Mukhtar A, Joni AAM, Kusin FM, Mohamed KN, et al.

Mar Pollut Bull, 2021 Dec;173(Pt B):113071.

PMID: 34741924 DOI: 10.1016/j.marpolbul.2021.113071

This study aimed to identify the toxicity effect of Diuron on Tegillarca granosa by determining accumulation in the soft tissues and alteration on the gill tissue structure. Wild stocks T. granosa were grouped to identify the initial Diuron concentration and 48-h exposure in different concentrations (0, 1, 2, 3, and 4 mg·L-1). The Diuron in tissue was extracted using an established procedure and identified using High-Performance Liquid Chromatography (HPLC). Gills were analysed for histopathological study; tissue structure was classified and scored using a developed scoring system. Diuron concentration in the soft tissue of exposed T. granosa was in the range 1.27-8.09 mg·kg-1, w/w and not proportionately increase along with the exposure concentration. The mean index values of the gill histopathology ranged from 5.25-7.67 and classified as moderate to severe. Gills characteristics and T. granosa protective behaviour potentially limit Diuron accumulation in the soft tissue.

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