MyMedR

Displaying all 6 publications

Abstract:

Sort:

Fulltext Alpha-Glucosidase Enzyme Biosensor for the Electrochemical Measurement of Antidiabetic Potential of Medicinal Plants

Mohiuddin M, Arbain D, Islam AK, Ahmad MS, Ahmad MN

Nanoscale Res Lett, 2016 Dec;11(1):95.
PMID: 26887579 DOI: 10.1186/s11671-016-1292-1

A biosensor for measuring the antidiabetic potential of medicinal plants was developed by covalent immobilization of α-glucosidase (AG) enzyme onto amine-functionalized multi-walled carbon nanotubes (MWCNTs-NH2). The immobilized enzyme was entrapped in freeze-thawed polyvinyl alcohol (PVA) together with p-nitrophenyl-α-D-glucopyranoside (PNPG) on the screen-printed carbon electrode at low pH to prevent the premature reaction between PNPG and AG enzyme. The enzymatic reaction within the biosensor is inhibited by bioactive compounds in the medicinal plant extracts. The capability of medicinal plants to inhibit the AG enzyme on the electrode correlates to the potential of the medicinal plants to inhibit the production of glucose from the carbohydrate in the human body. Thus, the inhibition indicates the antidiabetic potential of the medicinal plants. The performance of the biosensor was evaluated to measure the antidiabetic potential of three medicinal plants such as Tebengau (Ehretis laevis), Cemumar (Micromelum pubescens), and Kedondong (Spondias dulcis) and acarbose (commercial antidiabetic drug) via cyclic voltammetry, amperometry, and spectrophotometry. The cyclic voltammetry (CV) response for the inhibition of the AG enzyme activity by Tebengau plant extracts showed a linear relation in the range from 0.423-8.29 μA, and the inhibition detection limit was 0.253 μA. The biosensor exhibited good sensitivity (0.422 μA/mg Tebengau plant extracts) and rapid response (22 s). The biosensor retains approximately 82.16 % of its initial activity even after 30 days of storage at 4 °C.
Fulltext Industry 4.0 implementation and Triple Bottom Line sustainability: An empirical study on small and medium manufacturing firms

Jayashree S, Reza MNH, Malarvizhi CAN, Mohiuddin M

Heliyon, 2021 Aug;7(8):e07753.
PMID: 34430741 DOI: 10.1016/j.heliyon.2021.e07753

Background: The current level of industrialization has generated many challenges worldwide, including ecological hazards, climate change, and the overuse of non-renewable natural resources, thereby creating an increasing demand for achieving the goal of the Triple Bottom Line (TBL). In this regard, Industry 4.0 can be used as a crunch point to contribute to the production process that can help achieve sustainable development.
Purpose: While the Malaysian government proposed the "Industry4ward" approach to enhance technological adoption, there is scarce empirical evidence in the literature that validates SMEs for Industry 4.0. Using Dynamic Capability View (DCV), this study proposes a framework that includes core determinants like top management commitment, supply chain integration, and IT infrastructure, that can significantly influence Industry 4.0 implementation toward achieving TBL sustainability.
Design/methodology/approach: Employing simple random sampling, the study adopted a quantitative approach based on 199 useable respondent's feedback collected through a survey questionnaire of 900 employees from Malaysian SMEs. The statistical analysis was performed using Structural Equation Modeling (Partial Least Square, SmartPLS 3.3.2).
Findings: The results show that top management and IT infrastructure significantly impact Industry 4.0 implementation and sustainability. In contrast, the analysis also demonstrates that supply chain integration is insignificant to Industry 4.0 implementation in SMEs. The findings also indicate that the relationship between the determinants of Industry 4.0 and TBL sustainability can be mediated by the "effective implementation" of Industry 4.0.
Recommendations: The study highlights the practical consequences of the role and use of the determinants in Industry 4.0 implementation. Its findings help managers and policy-makers to optimize value creation to achieve sustainable development goals.
Limitations and future research: Focusing only on Malaysian manufacturing SMEs may restrict the generalization of the study; thus, a benchmarking analysis from other industrial settings is encouraged. The questionnaire-based survey is a further limitation of the study.
Intention and behavior towards green consumption among low-income households

Al Mamun A, Mohamad MR, Yaacob MRB, Mohiuddin M

J Environ Manage, 2018 Dec 01;227:73-86.
PMID: 30172161 DOI: 10.1016/j.jenvman.2018.08.061

In order to address the issues of climate change through wise management of resources and environmental conservation, this study examined the intention and behavior towards green consumption among low-income households. This study was a cross-sectional that relied on 380 low-income household respondents who lived in coastal areas of Peninsular Malaysia. The findings revealed a positive effect of eco-literacy and self-efficacy on attitude towards green products. Subsequently, the findings also ascertained a positive effect of attitude and perceived behavioral control on intention and consumption of green products. In addition, both scholars and policymakers can rely on these findings to increase the intention and behavior towards the consumption of green products in order to reduce the environmental vulnerability to the coastal communities. Therefore, responsible organizations should implement programs and policies that minimize the adverse effects of climate change through resource management and environmental conservation by promoting the use of green products among Malaysians.
Fulltext Social Connections and Self-Perceived Depression: An Enhanced Model for Studying Teenagers' Mental Wellbeing

Sarwar A, Islam MA, Mohiuddin M, Tareq MA, Siddika A

Int J Environ Res Public Health, 2022 Nov 27;19(23).
PMID: 36497866 DOI: 10.3390/ijerph192315791

The rising prevalence of depression among teenagers in Malaysia as well as globally makes it a vital issue to study. The purpose of this research is to examine the effects of social connection and self-perceived depression towards the improved mental wellbeing of the teenagers of Malaysia. Moreover, the mediating role of self-perceived depression on the improvement of the mental wellbeing of teenagers is examined in this study. This study followed a questionnaire-based approach. The sample of this study included 289 students aged between 15 and 19 years from Klang Valley, Malaysia. Prior permission was obtained from school authorities as well as from parents to allow their children to participate in the survey. To find out the structural relationship between the variables, PLS-SEM was utilized. This study finds that stronger social connections with family and friends may result in reduced self-perceived depression among Malaysian teenagers. Moreover, self-perceived depression among the teenagers surveyed had a negative effect on their improved mental wellbeing. The findings of this study will significantly affect how depression theories are currently understood and have consequences for social work, services, and policy interventions regarding teenagers in Malaysia.
Fulltext Willingness to pay premium prices for green buildings: evidence from an emerging economy

Al Mamun A, Rahman MK, Masud MM, Mohiuddin M

Environ Sci Pollut Res Int, 2023 Jul;30(32):78718-78734.
PMID: 37273051 DOI: 10.1007/s11356-023-27998-9

The building sector is one of the major contributors to greenhouse gas (GHG) emissions, which may impede the achievement of Malaysia's intended nationally determined contribution (INDC) by 2030. Therefore, this paper is aimed at identifying the underlying factors that affect working adults' willingness to pay (WTP) premium prices for green buildings. Data were collected from a total of 1198 respondents and analyzed using structural equitation modeling partial least square (SEM-PLS) to measure the willingness to pay for green buildings among working adults in Malaysia. The findings reveal that environmental literacy affects environmental belief as well as awareness of consequences among working adults in Malaysia. The findings also reveal that incentives for green building buyers have a significant impact on perceived behavioral control, while awareness of consequences has a significant influence on ascription of responsibility. However, the results reveal that awareness of consequences does not influence buyers' willingness to pay for green buildings. Moreover, the ascription of responsibility and perceived behavioral control have a significant effect on willingness to pay for green buildings. The findings of this study will help the concerned authorities to take appropriate steps to promote willingness to pay for green buildings, which will contribute significantly to the realization of INDC by 2030 as part of the Paris Agreement.
Fulltext Bis{4-[(2-hy-droxy-5-meth-oxy-3-nitro-benzyl-idene)amino]-phen-yl} ether

Arafath MA, Kwong HC, Adam F, Mohiuddin M, Sarker MS, Salim M, et al.

Acta Crystallogr E Crystallogr Commun, 2020 Jan 01;76(Pt 1):91-94.
PMID: 31921459 DOI: 10.1107/S2056989019016852

The mol-ecule of the title compound, C28H22N4O9, exhibits crystallographically imposed twofold rotational symmetry, with a dihedral angle of 66.0 (2)° between the planes of the two central benzene rings bounded to the central oxygen atom. The dihedral angle between the planes of the central benzene ring and the terminal phenol ring is 4.9 (2)°. Each half of the mol-ecule exhibits an imine E configuration. An intra-molecular O-H⋯N hydrogen bond is present. In the crystal, the mol-ecules are linked into layers parallel to the ab plane via C-H⋯O hydrogen bonds. The crystal studied was refined as a two-component pseudomerohedral twin.