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Fulltext Vancomycin treatment failure in a vancomycin susceptible methicillin-resistant Staphylococcus aureus (MRSA) infected patient

Norazah A, Salbiah N, Nurizzat M, Santhana R

Med J Malaysia, 2009 Jun;64(2):166-7.
PMID: 20058580 MyJurnal

A 64-year old patient, who had bacteraemia, did not respond to vancomycin despite the MRSA isolate being sensitive to the antibiotic at MIC 2 microg/mL. Electron microscopy of the MRSA isolate showed thickening of the cell wall, which was not observed in MRSA with lower vancomycin MIC.
Fulltext Kajian sero-prevalens penyakit hepatitis A di Mukim Hulu Langat, Selangor

Meftahuddin, T., Nik Rubiah, N.A.R., Salmiah, M.S., Salbiah, N., Venugopalans, B., Anisah, A.B., et al.

Malaysian Journal of Public Health Medicine, 2005;5(1):38-43.
MyJurnal

Kajian sero»prevalens dijalankan untuk menentukan prevalens kes Hepatitis A dan ciri-ciri demografinya di Kampung Pangsoon, Kampung Padang dan Kampung Lubuk Kelubi, di Mukim Hulu Langat, pada 15 dan 16 Mac 2003. Sebanyak 1643 sampel telah diperiksa dan didapati 995 kes (60.6%) telah terdeclah tehadap jangkitan Hepatitis A iaitu sebanyak 327 kes di Kampung Pangsoon, 400 kes, Kampung Padang dan 268 kes di Kampung Lubuk Kelubi. Majoriti kes adalah perempuan 545 kes (54 .7%), etnik Melayu 752 kes (75 .6%) , berusia kurang daripada 40 tahun (65%) dengan min umurnya 25 .4 tahun ( SP 1 9) dan tahap pendidikan di peringkat sekolah rendah. Kes di kalangan Orang Asli pula sebanyak 231 kes (23 .2%) . Lebih kurartg 40.3% kes telah bekerja, dengan pendapatan kurang daripada RM1000 sebulan. Majoriti kes mempunyai tandas sempurna 92Z( 95.4% ), sistem air limbah 846( 91 .2%), bekalan air seharrtat 930(96.4%) dan sistem lubang sampah 426( 44.6%) . Terdapat perbezaan yang bererti (p
Fulltext The presence of heterogeneous vancomycin-lntermediate Staphylococcus aureus (heteroVISA) in a major Malaysian hospital

Norazah A, Law NL, Abd Ghani MK, Salbiah N

Med J Malaysia, 2012 Jun;67(3):269-73.
PMID: 23082415

This study was conducted to detect the presence of heterogenous vancomycin-intermediate Staphylococcus aureus (heteroVISA) among MRSA isolates in a major hospital. Forty-three MRSA isolates with vancomycin MIC 2 microg/ml collected in 2009 was screened for heteroVISA using Etest Glycopeptide Resistance Detection (GRD) and confirmed by population analysis profile-area under curve method. The genetic relatedness of heteroVISA strains with other MRSA was examined by pulsed-field gel electrophoresis (PFGE) method. Two isolates were shown to be heteroVISA and derived from the same clone. This showed that heteroVISA strains were already present among our local strains since 2009 and were genetically related to other susceptible strains.
Species distribution and clinical profiles of coagulase-negative staphylococci (CoNS) isolated from blood cultures among paediatric patients in Hospital Kuala Lumpur

Siti NM, Wan Nazirah WAB, Rosni I, Mohamed AN, Salbiah N

Med J Malaysia, 2020 05;75(3):266-273.
PMID: 32467543

INTRODUCTION: Coagulase-negative staphylococci (CoNS) is often considered as a culture contaminants but it can potentially be pathogenic to patients with risk factors. A combination of species identification and clinical criteria has been suggested in determining true CoNS bacteraemia.
OBJECTIVES: To identify the species distribution, antibiotic susceptibility patterns and clinical profiles of CoNS isolated from blood cultures among paediatric patients in Hospital Kuala Lumpur (HKL).
METHODS: This study involved CoNS isolation from blood cultures of paediatric in-patients of the Paediatric Institute HKL. Isolates were identified to species level using Analytical Profile Index Staph identification strips and antimicrobial susceptibility pattern following Kirby-Bauer Disc Diffusion method. The clinical profiles of patients were obtained from their medical records.
RESULTS: Eleven CoNS species were identified from 148 isolates. Staphylococcus epidermidis was the most frequent species isolated (67.6%). The majority of the isolates showed resistance to penicillin (85.8%); while 70.3% were methicillin-resistant (MR) CoNS, which demonstrated a significant association with true infection (p=0.021). Predictors for significant CoNS infection included thrombocytopaenia, presence of predisposing factors, nosocomial infection, blood collected from peripheral vein, and CoNS isolated from two consecutive blood cultures. The most common predisposing factors for the isolation of CoNS were the presence of peripheral (54.1%) and central venous catheters (35.1%).
CONCLUSION: CoNS can cause significant bloodstream infections. The isolation of CoNS from blood cultures should be carefully interpreted by considering the predictive factors. Local data regarding predictive factors of patients with culture-positive CoNS, species distribution and antimicrobial susceptibility pattern are useful to determine the significance of blood culture results and care management of patients.
Fulltext Analgesic nephropathy as a cause of end-stage renal disease in Malaysia

Segasothy M, Suleiman AB, Hasnah A, Salbiah N, Shaharom CM, Siti Sabzah H, et al.

Med J Malaysia, 1986 Jun;41(2):134-8.
PMID: 3821608

We questioned 180 patients with end-stage renal disease on maintenance haemodialysis, chronic ambulatory peritoneal dialysis and those who had undergone renal transplantation at the Department of Nephrology, General Hospital, Kuala Lumpur. Twelve patients (6.7%) had consumed excessive quantities ofanalgesics prior to the institution of long-term dialysis or transplantation. Primary renal disease was considered to be analgesic nephropathy in seven patients (3.9%); in five patients (2.8%), analgesic abuse could have been a contributory factor to end-stage renal failure. Analgesic nephropathy is hence an uncommon cause of end-stage renal disease in Malaysia. However, it is important to be aware of the problem and to institute preventive measures as the cost of treatment for end-stage renal disease is prohibitive.
A fatal case of primary melioidotic prostatic abscess: the peril of poor drug compliance

Wahab AA, Norliyana N, Ding CH, Nurzam SCH, Salbiah N, Rao KR

Trop Biomed, 2020 Sep 01;37(3):560-565.
PMID: 33612771 DOI: 10.47665/tb.37.3.560

Primary prostatic melioidosis is a rare presentation of melioidosis even in melioidosis endemic areas. We report a case of a 58-year-old man with underlying diabetes mellitus who presented with a 5-day history of high-grade fever associated with lower urinary tract symptoms. Suprapubic tenderness and tender prostatomegaly were noted on examination. An abdominal computed tomography (CT) scan confirmed the presence of a prostatic abscess. Both blood and prostatic pus cultures grew Burkholderia pseudomallei. He was initially started on intravenous ceftazidime, followed by an escalation to intravenous meropenem. He was discharged home with oral amoxicillin-clavulanate and doxycycline after completing 12 days of meropenem. Unfortunately, his compliance to oral antibiotic therapy was poor, and he succumbed to the disease.