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The presence of heterogeneous vancomycin-lntermediate Staphylococcus aureus (heteroVISA) in a major Malaysian hospital

Norazah A 1 , Law NL 2 , Abd Ghani MK 3 , Salbiah N 4

Affiliations 

  • 1 Norazah Ahmad, MD, MSc, PhD. Institute for Medical Research, Bacteriology Unit, Infectious Diseases Research Centre, Jalan Pahang, Kuala Lumpur, Wilayah Persekutuan 50588 Malaysia. norazah@imr.gov.my
  • 2 Law Ngiik Ling, BSc. Faculty of Biomedicine, National University of Malaysia, Kuala Lumpur, Malaysia.
  • 3 Mohamed Kamel Abd Ghani, MD. Faculty of Biomedicine, National University of Malaysia, Kuala Lumpur, Malaysia.
  • 4 Salbiah Nawi, MPath. Selayang Hospital, Selangor, Malaysia.
Med J Malaysia, 2012 Jun;67(3):269-73.
PMID: 23082415

Abstract

This study was conducted to detect the presence of heterogenous vancomycin-intermediate Staphylococcus aureus (heteroVISA) among MRSA isolates in a major hospital. Forty-three MRSA isolates with vancomycin MIC 2 microg/ml collected in 2009 was screened for heteroVISA using Etest Glycopeptide Resistance Detection (GRD) and confirmed by population analysis profile-area under curve method. The genetic relatedness of heteroVISA strains with other MRSA was examined by pulsed-field gel electrophoresis (PFGE) method. Two isolates were shown to be heteroVISA and derived from the same clone. This showed that heteroVISA strains were already present among our local strains since 2009 and were genetically related to other susceptible strains.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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