Endometrial cancer (EC) is the most common gynaecological cancer amongst women in the UK. Although previous studies have found that women with polycystic ovary syndrome (PCOS) have at least a three-fold increase in endometrial cancer (EC) risk compared to women without PCOS, the precise molecular mechanisms which link between PCOS and EC remain unclear. It has been suggested that insulin resistance may contribute to the increased risk of EC in PCOS. The specific expression of genes related to the insulin-signalling pathway including the IGF system in the endometrium of women with PCOS has however never been measured and compared to that in women with EC without PCOS and control women without EC or PCOS. .
Study site: University teaching hospital in the United Kingdom
Gamma and delta tocotrienols are isomers of Vitamin E with established potency in pre-clinical anti-cancer research. This single-dose, randomized, crossover study aimed to compare the safety and bioavailability of a new formulation of Gamma Delta Tocotrienol (GDT) in comparison with the existing Tocotrienol-rich Fraction (TRF) in terms of gamma and delta isomers in healthy volunteers. Subjects were given either two 300 mg GDT (450 mg γ-T3 and 150 mg δ-T3) capsules or four 200 mg TRF (451.2 mg γ-T3 &102.72 mg δ-T3) capsules and blood samples were taken at several time points over 24 hours. Plasma tocotrienol concentrations were determined using HPLC method. The 90% CI for gamma and delta tocotrienols for the ratio of log-transformation of GDT/TRF for Cmax and AUC0-∞ (values were anti-logged and expressed as a percentage) were beyond the bioequivalence limits (106.21-195.46, 154.11-195.93 and 52.35-99.66, 74.82-89.44 respectively). The Wilcoxon Signed Rank Test for Tmax did not show any significant difference between GDT and TRF for both isomers (p > 0.05). No adverse events were reported during the entire period of study. GDT was found not bioequivalent to TRF, in terms of AUC and Cmax. Gamma tocotrienol in GDT showed superior bioavailability whilst delta tocotrienol showed less bioavailability compared to TRF.
Study site: Clinical examination ward, Universiti Malaya Medical Centre UMMC, Malaysia.
Kualiti merupakan elemen terpenting dalam proses pengeluaran atau perkhidmatan yang dihasilkan oleh sesebuah organisasi kepada pelanggan. Kualiti perkhidmatan merujuk kepada ukuran bagaimana sesuatu perkhidmatan yang disampaikan sepadan dengan jangkaan pengguna. Kajian ini bertujuan untuk mengenal pasti kualiti perkhidmatan kesihatan awam yang dapat diakses oleh buruh asing. Pengukuran kualiti perkhidmatan kesihatan dalam kajian ini dapat dibahagikan kepada tiga aspek iaitu keadaan perkhidmatan kesihatan, tempoh masa menunggu dan layanan kakitangan hospital terhadap buruh asing. Dapatan kajian menunjukkan sebilangan besar buruh asing berpuas hati dengan kualiti perkhidmatan kesihatan yang diterima oleh mereka.
Extract: In 1910 I was holding the appointment of Medical Officer and Magistrate at Anguilla in the St. Kits presidency of the Leeward Islands, British West Indies, when the Administrator one day handed me a cable, asking if I would accept the Medical Superintendency of the “Central Lunatic Asylum,” Tanjong Rambutan, Perak, Federated Malay States. Fortunately the cable explained that Tanjong Rambutan was in the Federated Malay States, as neither he nor I had the slightest idea where it was.
Nurses play a key role in caring for the mentally ill and in rehabilitating them after an episode of illness. The nurses' attitude towards a patient is generally considered to be one of the basic factors contributing to the administration of total therapeutic nursing care. The purpose of this study was to examine whether attitudes towards mental patients improve after psychiatric attachment as well as the relationship between attitudes to psychiatry and intention to pursue psychiatry as a career. The study was conducted on sixty nursing students of fifth semester at the Kolej Kejururawatan Kubang Kerian, Kelantan who are doing their psychiatric postings in Hospital Raja Perempuan Zainab II, Kota Bharu. The sampling technique for this study was convenient sampling. The instrument used for this study surveyed questionnaire developed by Brenda Happell (Happell, 2008). This quasi-experimental study measured changes in students' attitudes and satisfaction with clinical experience following a placement in mental health nursing. The questionnaire was administered to the nursing students on the first and last day of their psychiatric clinical placement session. The findings suggested that clinical experience during psychiatric clinical posting can positively influence attitudes, preparedness for practice and the popularity of mental health nursing. Satisfaction with clinical experience was also high. The findings of this study suggest that clinical postings had positive effects on nursing students' attitudes towards psychiatric patients and confidence in this field of practice.
Study site: Hospital Raja Perempuan Zainab II, Kota Bharu
Objective: A quick assessment tool for screening individuals with depression or anxiety is pertinent in mental-health set up. This study aims to validate the K10 and the K6 to screen patients with non-specific
psychological distress in a Malaysian population.
Methods: Translation of the questionnaire was done from English to Malay. Face validity was conducted on patients, and a pilot study was performed to assess the reliability of the K10 questionnaire. Fieldwork was conducted to determine the reliability and validity of the K10 questionnaire based on convenience sampling of healthy individuals and patients diagnosed with psychiatric illness. Malay version for K10 was administered to healthy participants (group without psychological distress) and patients on psychiatric clinic follow up (psychological distress). Data collection was done between August 2016 and September 2016.
Result: A total of 94 subjects were recruited in the study, of which 32 formed the case group. The Cronbach’s alpha coefficients for K10
were 0.837(control) and 0.885 (case), as for K6 were 0.716 (control) and 0.859 (case). The total score of the
K10 and the K6 clearly differentiated between the control and case groups (p
OBJECTIVES: To determine the prevalence of cases and episodes of needlestick injury among three groups of health care workers in the past one-year, the level of knowledge on blood-borne diseases and universal precautions and the practice of universal precautions. Other factors associated with the occurrence of needlestick injuries and the reporting of needlestick injuries were also analysed.
METHODS: A cross-sectional study was conducted in May 2003 to study the needlestick injuries among 285 health care workers (doctors, nurses, medical students) in a public teaching hospital in Negeri Sembilan, Malaysia.
RESULTS: The prevalence of needlestick injuries among the respondents was 24.6% involving 71 cases i.e. 48.0% among doctors, 22.4% among medical students, and 18.7% among nurses and the difference was statistically significant (p<0.001). There were a total of 174 episodes of needlestick injury. Prevalence of episode of needlestick injuries was highest among doctors (146%), followed by nurses (50.7%) and medical students (29.4%). Cases of needlestick injuries attained lower scores on practice of universal precautions compared to non-cases (p<0.001). About 59% of cases of needlestick injury did not report their injuries.
CONCLUSIONS: The study showed that needlestick injuries pose a high risk to health care workers and it is underreported most of the time. Many needlestick injuries can be prevented by strictly following the practice of universal precautions.
Tujuan menjalankan kajian ini adalah untuk mengetahui tahap kekerapan penyelidikan yang berkaitan dengan kesihatan mental yang dijalankan di fasiliti Kementerian Kesihatan Malaysia. Sebanyak 258 fasiliti Kementerian Kesihatan yang terlibat dalam kajian ini meliputi Hospital Mental, Hospital dengan perkhidmatan Pakar Psikiatri, Hospital tanpa perkhidmatan Pakar Psikiatri dan Pejabat Kesihatan Daerah. Borang kajiselidik telah dihantar melalui pos kepada Pengarah Hospital dan Pegawai Kesihatan Daerah dengan kadar maklumbalas 70.2%. Hasil kajian mendapati hanya 23(13.1%) fasiliti sahaja yang menjalankan kajian mengenai kesihatan mental. Sebanyak 37 kajian berkaitan kesihatan mental telah dijalankan bagi tahun 2003-2004. Penyebab utama penyelidikan kurang dijalankan disebabkan oieh peruntukan yang tidak mencukupi dan tiada kepakaran untuk menjalankan penyelidikan yang berkaitan dengan kesihatan mental. Antara penyebab lain adalah kekurangan anggota, NGO tidak berminat dan tiada latihan. Kesimpulannya menunjukkan tahap penyelidikan kesihatan mental di fasiliti Kementerian Kesihatan masih rendah.