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Fulltext Solid-phase electrochemical reduction of graphene oxide films in alkaline solution

Basirun WJ, Sookhakian M, Baradaran S, Mahmoudian MR, Ebadi M

Nanoscale Res Lett, 2013;8(1):397.
PMID: 24059434 DOI: 10.1186/1556-276X-8-397

Graphene oxide (GO) film was evaporated onto graphite and used as an electrode to produce electrochemically reduced graphene oxide (ERGO) films by electrochemical reduction in 6 M KOH solution through voltammetric cycling. Fourier transformed infrared and Raman spectroscopy confirmed the presence of ERGO. Electrochemical impedance spectroscopy characterization of ERGO and GO films in ferrocyanide/ferricyanide redox couple with 0.1 M KCl supporting electrolyte gave results that are in accordance with previous reports. Based on the EIS results, ERGO shows higher capacitance and lower charge transfer resistance compared to GO.
Voltammetric sensing of formaldehyde by using a nanocomposite prepared by reductive deposition of palladium and platinum on polypyrrole-coated nitrogen-doped reduced graphene oxide

Mahmoudian MR, Basirun WJ, Woi PM, Hazarkhani H, Alias YB

Mikrochim Acta, 2019 05 22;186(6):369.
PMID: 31119482 DOI: 10.1007/s00604-019-3481-y

The study presents the synthesis of polypyrrole-coated palladium platinum/nitrogen-doped reduced graphene oxide nanocomposites (PdPt-PPy/N-rGO NC) via direct the reduction of Pd(II) and Pt(II) in the presence of pyrrole monomer, N-rGO and L-cysteine as the reducing agent. X-ray diffraction confirmed the presence of metallic Pd and Pt from the reduction of Pd and Pt cations. Transmission electron microscopy images revealed the presence of Pd, Pt and PPy deposition on N-rGO. Impedance spectroscopy results gave a decreased charge transfer resistance due to the presence of N-rGO. The nanocomposites were synthesized with different Pd/Pt ratios (2:1, 1:1 and 1:2). A glassy carbon electrode (GCE) modified with the nanocomposite showed enhanced electrochemical sensing capability for formaldehyde in 0.1 M sulfuric acid solution. Cyclic voltammetry showed an increase in the formaldehyde oxidation peak current at the GCE modified with Pd2Pt1 PPy N-rGO. At a typical potential of 0.45 V (vs. SCE), the sensitivity in the linear segment was 345.8 μA.mM -1. cm-2. The voltammetric response was linear between 0.01 and 0.9 mM formaldehyde concentration range, with a 27 µM detection limit (at S/N = 3). Graphical abstract Schematic presentation of formaldehyde detection by Pd2Pt1-PPy/nitrogen-doped reduced Graphene Oxide Nanocomposite (Pd2Pt1-PPy /N-Gr NC). The decrease of charge transfer resistance and the agglomeration of deposited metals in the presence of N-rGO enhance the current response of the electrochemical sensor.
Investigation of empathy amongst dietetic interns at selected primary and tertiary health-care facilities

Yang WY, Low YE, Ng WJ, Ong SH, Jamil JA

Nutr Diet, 2020 04;77(2):231-239.
PMID: 31199060 DOI: 10.1111/1747-0080.12562

AIM: Empathy is an essential aspect in the delivery of quality nutrition care and promoting better outcomes in patients. With an increased emphasis of patient-centred care in dietetic practice, empathy should underpin the construct of the curriculum in dietetic education. The present study investigated the empathy level of dietetic interns through self-reporting measures and patients' perception.
METHODS: This cross-sectional study was conducted on a total of 57 dietetic interns and 99 patients from primary and tertiary health care settings. The dietetic interns completed the Toronto Empathy Questionnaire (TEQ) while the Consultation and Relational Empathy (CARE) measure was self-administered by patients. Socio-demographic information of participants was collected.
RESULTS: The dietetic interns' mean (standard deviation [SD]) TEQ scores were 46.90 ± 5.28 and 47.78 ± 5.34 in primary and tertiary care, respectively. CARE measure scores rated by patients in the primary care were 38.61 ± 8.38 and for tertiary setting, the scores were slightly higher (39.47 ± 7.65). The settings, gender, ethnicity and period of internship did not affect dietetic interns' empathy level. In primary care, CARE scores were significantly different between patients' age grouping (P = 0.007).
CONCLUSIONS: Findings from the present study showed that patients' age significantly affected their perception of dietetic interns' empathy in primary health care. These preliminary findings could facilitate an understanding of the level of empathy amongst interns for consideration in the future design of dietetic training.
Fulltext Psychological well-being and its associated factors among university students in Sichuan, China

Wan J, Wee LH, Siau CS, Wong YH

Front Psychol, 2025;16:1473871.
PMID: 40083756 DOI: 10.3389/fpsyg.2025.1473871

INTRODUCTION: Psychological well-being refers to a mental state that allows an individual to achieve their full potential, be productive and innovative in their work, and manage everyday stressors. This study aims to assess university students' psychological well-being by examining its associations with demographic factors such as gender, only child status, family background, grade level, financial aid status, and household income.
METHODS: This cross-sectional, online study utilized the EPOCH Measure of Adolescent Well-being to examine five positive well-being indicators: Engagement, Perseverance, Optimism, Connectedness and Happiness among Chinese university students aged 18-25 years (N = 4,911).
RESULTS: The results showed that females, only children, first-year students, and urban students exhibited higher levels of psychological well-being. Additionally, students who received the highest level of financial assistance were significantly associated with lower levels of psychological well-being.
CONCLUSION: Identifying the influence of these socioeconomic factors on psychological well-being allows for targeted interventions to improve the mental health and social well-being of at-risk groups.
Integrated structural and chemical analyses for HCl-supported hydrochar and their adsorption mechanisms for aqueous sulfachloropyridazine removal

Liu L, Sim SF, Lin S, Wan J, Zhang W, Li Q, et al.

J Hazard Mater, 2021 Sep 05;417:126009.
PMID: 34229376 DOI: 10.1016/j.jhazmat.2021.126009

In this study, various HCl-supported hydrochar made from root powder of long-root Eichhornia crassipes were applied to adsorb aqueous sulfachloropyridazine (SCP). Adsorption capacity (qe μg g-1) was positively correlated with combined severity-CS. With CS increasing, carbonization degree, hydrophobicity, porosity and isoelectric point of hydrochar increased, but content of polar functional groups decreased. Hydrophobic interaction was important for SCP adsorption. A 24 × 36 peak area table was generated from 24 FT-IR absorbance spectra computed by peak detection algorithm. Afterwards, correlation analysis between qe μg g-1 and FT-IR peak area were conducted, indicating that wavenumbers at 555.4, 1227.47, 1374.51, 1604.5, 2901.4/2919.2 and 3514.63 cm-1 were helpful for SCP adsorption. Further, multivariate linear regression analyses showed that aromatic skeleton and phenolic hydroxyl were the two biggest contributors. Electrostatic attraction did not exist during the SCP adsorption process. Under strong acid condition, protonated amino groups in cationic SCP acting as a hydrogen donator interacted with electron-rich functional groups onto hydrochar by Hydrogen interaction. Under weak acid condition, neutral SCP served as an π electron donor to bond with hydrochar by π-π electron donator-acceptor interaction. This work could guide the functional groups modification strategy of hydrochar to make better use of it in water purification field.
Association between serum vitamin D levels and venous thromboembolism (VTE): A systematic review and meta-analysis of observational studies

Wan J, Yuan J, Li X, Bao Y, Hou Y, Li Z, et al.

Complement Ther Med, 2020 Nov;54:102579.
PMID: 33183675 DOI: 10.1016/j.ctim.2020.102579

OBJECTIVE: Although many studies have attempted to unravel the relationship between vitamin D deficiency and the incidence of VTE, the results remained inconsistent. To address this discrepancy, we performed a systematic review and meta-analysis to precisely disentangle the relationship between serum vitamin D levels and VTE risk.
METHODS: The Web of Science, Scopus, PubMed/Medline, Embase, and Google Scholar databases were searched for all available observational studies that reported the risk of venous thromboembolism (VTE) based on serum vitamin D levels categories. The search was performed up to March 2020.
RESULTS: Seven studies were included. The overall analysis showed a significantly increased risk of VTE in subjects with low levels of serum vitamin D compared with those with normal vitamin D levels (RR = 1.34; 95% CI: 1.07-1.69; P = 0.011). In a sensitivity analysis, we did not observe a significant effect of any individual study on the combined effect sizes. Nevertheless, significant heterogeneity was present among the studies (Cochrane Q test, p = 0.018, I2 = 61%). In the stratified analysis, low vitamin D levels were positively associated with an increased risk of VTE in prospective population-based studies (RR = 1.31; 95% CI: 1.06-1.61; P = 0.010) and in subjects below 60 years old (RR = 1.28; 95% CI: 1.07-1.54; P = 0.060).
CONCLUSION: our systematic review and meta-analysis showed that a low serum vitamin D level was indeed associated with an increased risk of VTE.
Vector-Mediated Cancer Gene Therapy Reduces Toxicity and Inhibition of Lung Carcinoma Growth in Nude Mice

Khalaf AT, Wan J, Wei H, Fubing S, Zainol J, Kadir SYA, et al.

Appl Biochem Biotechnol, 2024 Jan;196(1):261-274.
PMID: 37119504 DOI: 10.1007/s12010-023-04463-4

Replication-competent oncolytic adenovirus (TOA2) gene therapy is a recently introduced anti-tumor treatment regimen with superior results. The biodistribution studies of virus vector-based medicine seem more cautious and have been given much attention recently in terms of its quality and safety in preclinical trials. The current study determined the biodistribution and safety of a replication-competent adenovirus in different organs to predict its toxicity threshold. The present study has used TOA2, while biodistribution analysis was performed in human lung carcinoma A549-induced tumor-bearing nude mice model. Intratumoral injection was applied onto tumor-bearing mice with the adenovirus (3×1010 VP per mouse). Mice were sacrificed at the end of the experiment and the organs were dissected. Biodistribution analysis was done with complete hexon gene detection in each organ using quantitative real-time polymerase chain reaction (qRT-PCR). The biodistribution and concentration profiles showed that the TOA2 is well distributed in the entire tumor tissue. After dose 3 at day 11, the concentration of the virus has increased in the tumor tissue from 2240.54 (± 01.69) copies/100 ng genome to 13,120.28 (± 88.21) copies/100 ng genome on the 18th day, which eventually approached 336.45 (± 23.41) copies/100ng genome on the day 36. On the contrary, the concentration of the same decreased in the order of the liver, kidney, spleen, lung, and heart over time but no distributional traces in gonads. But the concentration found decreased dramatically in blood and other organs, while at the end of the experiment no detectable distribution was seen besides tumor tissue. The study confirms that adenovirus-based tumor therapy using conditionally replicating competent oncolytic TOA2 exhibited great efficiency with no toxicity at all.
Injectable Hyaluronic Acid Filler for Increasing Head Circumference and Contouring Cephalic Flatness: An Innovative Approach

Wan J, Kim SB, Yoon SE, Jalali A, Thulesen J, Frank K, et al.

Aesthetic Plast Surg, 2025 Feb 12.
PMID: 39937230 DOI: 10.1007/s00266-025-04708-z

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Fulltext Stress and burnout syndrome in health-care providers treating dengue infection: A cross-sectional study

Boo YL, Liam CCK, Lim SY, Look ML, Tan MH, Ching SM, et al.

Med J Malaysia, 2018 12;73(6):371-375.
PMID: 30647206

INTRODUCTION: Increased prevalence of dengue fever had led to increase stress in providing optimal care for patients. This has been identified as a potential factor that may lead to negative health effects on medical doctors. This study was designed to review the prevalence and associated factors of burnout syndrome (including depression, anxiety, and stress level) among clinicians in the setting of increasing cases of dengue in Malaysia.

METHODS: A cross-sectional, multi-centre study was carried out among doctors in contact with patients with dengue infection from four major hospitals in Malaysia in 2015 using Maslach Burnout Inventory and DASS-21 questionnaire.

RESULTS: A total of 313 respondents were included in this study with 15.9% of the respondents experiencing high burnout syndrome. Long working hours, depression, anxiety, and stress were significantly associated with high degree of burnout syndrome (p<0.05). However, number of dengue cases reviewed was not significantly associated with the degree of burnout syndrome. Depression and stress were among factors identified as the predictors for burnout syndrome.

CONCLUSION: High degree of burnout syndrome among clinicians with significant correlations with symptoms of depression and stress will require early identification to enable early measures to resolve, as well as prevent it. Future studies with more hospitals involvement should be conducted to establish the relationship between the degree of burnout syndrome and prevalence of dengue infection.
High-Voltage Long-Cycling All-Solid-State Lithium Batteries with High-Valent-Element-Doped Halide Electrolytes

Ye Y, Geng J, Zuo D, Niu K, Chen D, Lin J, et al.

ACS Nano, 2024 Jul 16;18(28):18368-18378.
PMID: 38970500 DOI: 10.1021/acsnano.4c02678

All-solid-state batteries (ASSBs) have garnered considerable attention as promising candidates for next-generation energy storage systems due to their potentially simultaneously enhanced safety capacities and improved energy densities. However, the solid future still calls for materials with high ionic conductivity, electrochemical stability, and favorable interfacial compatibility. In this study, we present a series of halide solid-state electrolytes (SSEs) utilizing a doping strategy with highly valent elements, demonstrating an outstanding combination of enhanced ionic conductivity and oxidation stability. Among these, Li2.6In0.8Ta0.2Cl6 emerges as the standout performer, displaying a superionic conductivity of up to 4.47 mS cm-1 at 30 °C, along with a low activation energy barrier of 0.321 eV for Li+ migration. Additionally, it showcases an extensive oxidation onset of up to 5.13 V (vs Li+/Li), enabling high-voltage ASSBs with promising cycling performance. Particularly noteworthy are the ASSBs employing LiCoO2 cathode materials, which exhibit an extended cyclability of over 1400 cycles, with 70% capacity retention under 4.6 V (vs Li+/Li), and a capacity of up to 135 mA h g-1 at a 4 C rate, with the loading of active materials at 7.52 mg cm-2. This study demonstrates a feasible approach to designing desirable SSEs for energy-dense, highly stable ASSBs.
Fulltext Bis-Iridoid Glycosides and Triterpenoids from Kolkwitzia amabilis and Their Potential as Inhibitors of ACC1 and ACL

Wan J, Zhao ZY, Wang C, Jiang CX, Tong YP, Zang Y, et al.

Molecules, 2024 Dec 18;29(24).
PMID: 39770069 DOI: 10.3390/molecules29245980

A comprehensive phytochemical investigation of the twigs/leaves and flower buds of Kolkwitzia amabilis, a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (1-4 and 7-13), 20 triterpenoids (5, 6, and 14-31), and 8 phenylpropanoids (32-39). Among these, amabiliosides A (1) and B (2) represent previously undescribed bis-iridoid glycosides, while amabiliosides C (3) and D (4) feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro-β-carboline-5-carboxylic acid moiety. Amabiliacids A (5) and B (6) are 24-nor-ursane-type triterpenoids characterized by an uncommon ∆11,13(18) transannular double bond. Their chemical structures and absolute configurations were elucidated through spectroscopic data and electronic circular dichroism analyses. Compound 2 exhibited a moderate inhibitory effect against acetyl CoA carboxylase 1 (ACC1), with an IC50 value of 9.6 μM. Lonicejaposide C (8), 3β-O-trans-caffeoyl-olean-12-en-28-oic acid (29), and (23E)-coumaroylhederagenin (31) showed notable inhibitory effects on ATP-citrate lyase (ACL), with IC50 values of 3.6, 1.6, and 4.7 μM, respectively. Additionally, 3β-acetyl-ursolic acid (17) demonstrated dual inhibitory activity against both ACC1 and ACL, with IC50 values of 10.3 and 2.0 μM, respectively. The interactions of the active compounds with ACC1 and ACL enzymes were examined through molecular docking studies. From a chemotaxonomic perspective, the isolation of bis-iridoid glycosides in this study may aid in clarifying the taxonomic relationship between the genera Kolkwitzia and Lonicera within the Caprifoliaceae family. These findings highlight the importance of conserving plant species with unique and diverse secondary metabolites, which could serve as potential sources of new therapeutic agents for treating ACC1/ACL-associated diseases.
Advanced High-Entropy Halide Solid Electrolytes Enabling High-Voltage, Long-Cycling All-Solid-State Batteries

Ye Y, Gu Z, Geng J, Niu K, Yu P, Zhou Y, et al.

Nano Lett, 2025 Mar 12;25(10):3747-3755.
PMID: 40015691 DOI: 10.1021/acs.nanolett.4c05460

Stable solid electrolytes are essential for advancing the safety and energy density of lithium batteries, especially in high-voltage applications. In this study, we designed an innovative high-entropy chloride solid electrolyte (HE-5, Li2.2In0.2Sc0.2Zr0.2Hf0.2Ta0.2Cl6), using multielement doping to optimize both ionic conductivity and high-voltage stability. The high-entropy disordered lattice structure facilitates lithium-ion mobility, achieving an ionic conductivity of 4.69 mS cm-1 at 30 °C and an activation energy of 0.300 eV. Integration of HE-5 into all-solid-state batteries (ASSBs) with NCM83 cathodes and a Li-In anode enables outstanding electrochemical performance, sustaining 70% capacity retention over 1600 cycles at a 4 C rate. Moreover, the high configurational entropy stabilizes the electrolyte's structure at elevated voltages, enabling stable operation at 5.0 V without significant degradation. Our work presents the dual advantages of high-entropy engineering in boosting high ionic conductivity and voltage stability, providing a broad roadmap for next-generation energy-dense ASSBs.
Integrated image-based deep learning and language models for primary diabetes care

Li J, Guan Z, Wang J, Cheung CY, Zheng Y, Lim LL, et al.

Nat Med, 2024 Jul 19.
PMID: 39030266 DOI: 10.1038/s41591-024-03139-8

Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary care physicians (PCPs), particularly in low-resource settings. Here, to bridge the gaps, we developed an integrated image-language system (DeepDR-LLM), combining a large language model (LLM module) and image-based deep learning (DeepDR-Transformer), to provide individualized diabetes management recommendations to PCPs. In a retrospective evaluation, the LLM module demonstrated comparable performance to PCPs and endocrinology residents when tested in English and outperformed PCPs and had comparable performance to endocrinology residents in Chinese. For identifying referable DR, the average PCP's accuracy was 81.0% unassisted and 92.3% assisted by DeepDR-Transformer. Furthermore, we performed a single-center real-world prospective study, deploying DeepDR-LLM. We compared diabetes management adherence of patients under the unassisted PCP arm (n = 397) with those under the PCP+DeepDR-LLM arm (n = 372). Patients with newly diagnosed diabetes in the PCP+DeepDR-LLM arm showed better self-management behaviors throughout follow-up (P

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