Displaying publications 1 - 20 of 41 in total

  1. Yong WK, Ho YF, Malek SN
    Pharmacogn Mag, 2015 Oct;11(Suppl 2):S275-83.
    PMID: 26664015 DOI: 10.4103/0973-1296.166069
    Xanthohumol, a major prenylated chalcone found in female hop plant, Humulus lupulus, was reported to have various chemopreventive and anti-cancer properties. However, its apoptotic effect on human alveolar adenocarcinoma cell line (A549) of non-small cell lung cancer (NSCLC) was unknown.
  2. Ooh KF, Ong HC, Wong FC, Sit NW, Chai TT
    Pharmacogn Mag, 2014 Aug;10(Suppl 3):S443-55.
    PMID: 25298659 DOI: 10.4103/0973-1296.139767
    The phytochemistry and bioactivity of wetland macrophytes are underexplored. Plants are known as the natural sources of phytochemical beneficial to health.
  3. Emeka PM, Badger-Emeka LI, Eneh CM, Khan TM
    Pharmacogn Mag, 2014 Apr;10(Suppl 2):S357-62.
    PMID: 24991115 DOI: 10.4103/0973-1296.133282
    The aim of the study was to investigate the effects of dietary combination of Nigella sativa seed and oil extracts with chloroquine (CQ), and how these combinations enhance CQ efficacy in mice infected with Plasmodium berghei and their survival rates.
  4. Kingsley B, Kayarohanam S, Brindha P, Subramoniam A
    Pharmacogn Mag, 2014 Apr;10(Suppl 2):S283-7.
    PMID: 24991104 DOI: 10.4103/0973-1296.133277
    Acacia farnesiana is a medicinal plant that grows throughout tropical parts of Indian subcontinent, particularly in sandy soils of river beds in Northern India. The objective of the present study was to evaluate the anti-hyperglycemic activity of the extracts using glucose tolerance test. Isolation of an active fraction (AF) from the active extract (water extract) using alcohol precipitation and to get insight to the mechanism of action of the AF of A. farnesiana.
  5. Wong SK, Lim YY, Ling SK, Chiang Chan EW
    Pharmacogn Mag, 2014 Apr;10(Suppl 2):S232-9.
    PMID: 24991097 DOI: 10.4103/0973-1296.133238
    Our earlier study on the antiproliferative (APF) activity of leaf extracts of ten Apocynaceae species showed that leaves of Vallaris glabra possessed strong and broad-spectrum properties.
  6. Vijayakumar B, Parasuraman S, Raveendran R, Velmurugan D
    Pharmacogn Mag, 2014 Aug;10(Suppl 3):S639-44.
    PMID: 25298685 DOI: 10.4103/0973-1296.139809
    Cleistanthins A and B are isolated compounds from the leaves of Cleistanthus collinus Roxb (Euphorbiaceae). This plant is poisonous in nature which causes cardiovascular abnormalities such as hypotension, nonspecific ST-T changes and QTc prolongation. The biological activity predictions spectra of the compounds show the presence of antihypertensive, diuretic and antitumor activities.
  7. Gundamaraju R, Vemuri RC, Singla RK, Manikam R, Rao AR, Sekaran SD
    Pharmacogn Mag, 2014 Aug;10(Suppl 3):S557-62.
    PMID: 25298674 DOI: 10.4103/0973-1296.139782
    The myocardium is generally injured in the case of reperfusion injury and arterial damage is caused by hypertension. In reference to these statements, the present study was focused. Cardiac glycosides were said to have protective effects against myocardial infarction and hypertension. Strophanthus hispidus was thus incorporated in the study.
  8. Goh SH, Alitheen NB, Yusoff FM, Yap SK, Loh SP
    Pharmacogn Mag, 2014 Jan;10(37):1-8.
    PMID: 24696543 DOI: 10.4103/0973-1296.126650
    Marine brown diatom Chaetoceros calcitrans and green microalga Nannochloropsis oculata are beneficial materials for various applications in the food, nutraceutical, pharmaceutical and cosmeceutical industries.
  9. Sim KS, Ibrahim H, Malek SN, Syamsir DR, Awang K
    Pharmacogn Mag, 2014 Jan;10(37):70-2.
    PMID: 24695515 DOI: 10.4103/0973-1296.126666
    Alpinia murdochii (Zingiberaceae) is a wild ginger species restricted to mountain areas of Peninsular Malaysia. Due to rapid development and deforestation activities, this species is becoming rare. This is the first report of the cytotoxic activity of A. murdochii.
  10. Ahmed F, Urooj A, Karim AA
    Pharmacogn Mag, 2013 Apr;9(34):130-4.
    PMID: 23772108 DOI: 10.4103/0973-1296.111265
    Ficus racemosa Linn. (Moraceae) bark is a rich source of phenolic compounds known to possess potential antioxidant activity offering numerous health benefits.
  11. Siddiqui MJ, Ismail Z, Saidan NH
    Pharmacogn Mag, 2011 Apr;7(26):92-6.
    PMID: 21716929 DOI: 10.4103/0973-1296.80662
    Vinca rosea (Apocynaceae) is one of the most important and high value medicinal plants known for its anticancer alkaloids. It is the iota of the isolated secondary metabolites used in chemotherapy to treat diverse cancers. Several high performance liquid chromatography (HPLC) methods have been developed to quantify the active alkaloids in the plant. However, this method may serve the purpose in quantification of V. rosea plant extracts in totality.
  12. Khoo ZY, Teh CC, Rao NK, Chin JH
    Pharmacogn Mag, 2010 Apr;6(22):120-4.
    PMID: 20668578 DOI: 10.4103/0973-1296.62899
    The objective of the present study was to evaluate the toxic effect of Averrhoa carambola (star fruit) juice at different storage conditions in Sprague Dawley (SD) rats. Twenty female rats weighing 180 +/- 20 g were randomly assigned into four groups with five rats per group (n = 5). First group served as the control group, fed with distilled water (vehicle). Second, third and fourth groups were orally treated with juice of A. carambola stored for 0, 1 and 3 h respectively for 14 days. Cage-side observations were done daily after each treatment. Body weight, food consumption and water intake were recorded on day-0, day-3, day-7 and day-14. All rats were fasted overnight prior to blood collection through cardiac puncture on day-15. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine in blood serum were measured. Data were analyzed using Dunnett's test. From the results obtained, there was no lethality found and LD(50) could not be determined. Increment of ALT levels (P<0.05) was reported in those rats treated with A. carambola juice stored for 3 h. On the basis of these results, we can conclude that A. carambola juice stored for 0 hand 1 h are safe to be consumed. However, juice stored for 3 h exerts toxic effect on rat liver at hepatocellular level.
  13. Sim KS, Nurestri AM, Norhanom AW
    Pharmacogn Mag, 2010 Jul;6(23):248-54.
    PMID: 20931088 DOI: 10.4103/0973-1296.66945
    The leaves of Pereskia grandifolia Haw. (Cactaceae), commonly known as "Jarum Tujuh Bilah" in Malaysia, have been traditionally used as natural remedy in folk medicine by the locals. In the present study, the antioxidant potential of P. grandifolia crude methanol and its fractionated extracts (hexane, ethyl acetate and water) have been investigated, employing three different established testing systems, such as scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, reducing power assay and β-carotene method. The total phenolic content of the P. grandifolia extracts was also assessed by the Folin-Ciocalteau's method. The ethyl acetate extract showed significantly the highest total phenolic content, DPPH scavenging ability and antioxidant activity in β-carotene bleaching assay while the hexane extract possessed significantly strongest reducing power. The data obtained in these testing systems clearly establish the antioxidant potency of P. grandifolia. As such, this is the first report on the antioxidant activities of P. grandifolia.
  14. Sim KS, Sri Nurestri AM, Sinniah SK, Kim KH, Norhanom AW
    Pharmacogn Mag, 2010 Jan;6(21):67-70.
    PMID: 20548939 DOI: 10.4103/0973-1296.59969
    Pereskia bleo and Pereskia grandifolia, belonging to the botanical family Cactaceae, have been traditionally used by the locals in Malaysia for treatment of various ailments. The current study reports the outcome of acute oral toxicity investigation of Pereskia bleo and Pereskia grandifolia, on ICR mice. No mortalities or evidence of adverse effects have been observed in ICR mice following acute oral administration at the highest dose of 2500 mg/ kg crude extracts of Pereskia bleo and Pereskia grandifolia. This is the first report on the acute oral toxicity of Pereskia bleo and Pereskia grandifolia and the findings of this study are in agreement with those of in vitro experiments and thus provide scientific validation on the use of the leaves of Pereskia bleo and Pereskia grandifolia.
  15. Narayanaswamy R, Isha A, Wai LK, Ismail IS
    Pharmacogn Mag, 2016 Jan;12(Suppl 1):S21-6.
    PMID: 27041853 DOI: 10.4103/0973-1296.176111
    Clinacanthus nutans (Burm. f.) Lindau has gained popularity among Malaysians as a traditional plant for anti-inflammatory activity.
  16. Wan Nor Hafiza WA, Yazan LS, Tor YS, Foo JB, Armania N, Rahman HS
    Pharmacogn Mag, 2016 Jan;12(Suppl 1):S86-95.
    PMID: 27041866 DOI: 10.4103/0973-1296.176107
    Ethyl acetate and dichloromethane extract of Dillenia suffruticosa (EADS and DCMDS, respectively) can be a potential anticancer agent. The effects of EADS and DCMDS on the growth of HeLa cervical cancer cells and the expression of apoptotic-related proteins had been investigated in vitro. Cytotoxicity of the extracts toward the cells was determined by 5-diphenyltetrazolium bromide assay, the effects on cell cycle progression and the mode of cell death were analyzed by flow cytometry technique, while the effects on apoptotic-related genes and proteins were evaluated by quantitative real-time polymerase chain reaction, and Western blot and enzyme-linked immunosorbent assay, respectively. Treatment with DCMDS inhibited (P < 0.05) proliferation and induced apoptosis in HeLa cells. The expression of cyclin B1 was downregulated that led to G2/M arrest in the cells after treatment with DCMDA. In summary, DCMDS induced apoptosis in HeLa cells via endoplasmic reticulum stress-induced apoptotic pathway and dysregulation of mitochondria. The data suggest the potential application of DCMDS in the treatment of cervical cancer.
  17. Wahyuni FS, Shaari K, Stanslas J, Lajis NH, Hamidi D
    Pharmacogn Mag, 2016 Jan;12(Suppl 1):S52-6.
    PMID: 27041859 DOI: 10.4103/0973-1296.176115
    To isolate compounds from the roots of Garcinia cowa and to evaluated their cytotoxic activity against breast (MCF-7), prostate (DU-145), and lung (H-460) cell lines.
  18. Fard MT, Arulselvan P, Karthivashan G, Adam SK, Fakurazi S
    Pharmacogn Mag, 2015 Oct;11(Suppl 4):S556-63.
    PMID: 27013794 DOI: 10.4103/0973-1296.172961
    Inflammation is a well-known physiological response to protect the body against infection and restore tissue injury. Nevertheless, the chronic inflammation can trigger various inflammatory associated diseases/disorder. Moringa oleifera is a widely grown plant in most tropical countries and it has been recognized traditionally for several medicinal benefits.
  19. De B, Bhandari K, Singla RK, Katakam P, Samanta T, Kushwaha DK, et al.
    Pharmacogn Mag, 2015 Oct;11(Suppl 4):S522-32.
    PMID: 27013789 DOI: 10.4103/0973-1296.172956
    Tulsi, Banyan, and Jamun are popular Indian medicinal plants with notable hypoglycemic potentials. Now the work reports chemo-profiling of the three species with in-vitro screening approach for natural enzyme inhibitors (NEIs) against enzymes pathogenic for type 2 diabetes. Further along with the chemometrics optimized extraction process technology, phyto-synergistic studies of the composite polyherbal blends have also been reported.
  20. Manaharan T, Thirugnanasampandan R, Jayakumar R, Kanthimathi MS, Ramya G, Ramnath MG
    Pharmacogn Mag, 2016 May;12(Suppl 3):S327-31.
    PMID: 27563220 DOI: 10.4103/0973-1296.185738
    Essential oil of Ocimum sanctum Linn. exhibited various pharmacological activities including antifungal and antimicrobial activities. In this study, we analyzed the anticancer and apoptosis mechanisms of Ocimum sanctum essential oil (OSEO).
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