MyMedR

Lung cancer: I. Presenting clinical features

Ashoka Menon M, Saw Huat Seong

Med J Malaysia, 1979 Mar;33(3):230-4.

PMID: 522728

Matched MeSH terms: Lung Neoplasms/diagnosis*

Fulltext A woman presenting with dry cough, hoarseness of voice and significant weight loss

Khajotia R

Malays Fam Physician, 2008;3(2):107.

PMID: 25606129

Matched MeSH terms: Lung Neoplasms

Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution

Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam

Sains Malaysiana, 2017;46:2529-2539.

Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternative inferential procedures that ease the assumptions of normality and unconventionally relies on the distribution of data in hand. In this research, a three parameter log-normal parametric survival model was extended to incorporate left-truncated and right censored medical data with covariates. Following that, bootstrap inferential procedures using non-parametric and parametric bootstrap samples were applied to the parameters of this model. The performance of the parameter estimates was assessed at various combinations of truncation and censoring levels via a simulation study. The recommended bootstrap intervals were applied to a lung cancer survival data.

Matched MeSH terms: Lung Neoplasms

Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier Based Drug Delivery Systems

Mehta M, Dhanjal DS, Satija S, Wadhwa R, Paudel KR, Chellappan DK, et al.

Curr Pharm Des, 2020;26(42):5380-5392.

PMID: 33198611 DOI: 10.2174/1381612826999201116161143

Cell Signaling pathways form an integral part of our existence that allows the cells to comprehend a stimulus and respond back. Such reactions to external cues from the environment are required and are essential to regulate the normal functioning of our body. Abnormalities in the system arise when there are errors developed in these signals, resulting in a complication or a disease. Presently, respiratory diseases contribute to being the third leading cause of morbidity worldwide. According to the current statistics, over 339 million people are asthmatic, 65 million are suffering from COPD, 2.3 million are lung cancer patients and 10 million are tuberculosis patients. This toll of statistics with chronic respiratory diseases leaves a heavy burden on society and the nation's annual health expenditure. Hence, a better understanding of the processes governing these cellular pathways will enable us to treat and manage these deadly respiratory diseases effectively. Moreover, it is important to comprehend the synergy and interplay of the cellular signaling pathways in respiratory diseases, which will enable us to explore and develop suitable strategies for targeted drug delivery. This review, in particular, focuses on the major respiratory diseases and further provides an in-depth discussion on the various cell signaling pathways that are involved in the pathophysiology of respiratory diseases. Moreover, the review also analyses the defining concepts about advanced nano-drug delivery systems involving various nanocarriers and propose newer prospects to minimize the current challenges faced by researchers and formulation scientists.

Matched MeSH terms: Lung Neoplasms*

Lung cancer: II. Diagnostic methods

Saw Huat Seong, Ashoka Menon M

Med J Malaysia, 1979 Mar;33(3):235-42.

PMID: 522729

Matched MeSH terms: Lung Neoplasms/diagnosis*

Fulltext Recent advances in the diagnosis and treatment of lung cancer

Liam CK, Lim KH, Wong MM

Med J Malaysia, 2001 Dec;56(4):514-31; quiz 532.

PMID: 12014776

Matched MeSH terms: Lung Neoplasms/diagnosis*; Lung Neoplasms/therapy*

Fulltext Cancer Metastases to the Hand: A Systematic Review and Meta-analysis

Dow T, Davis C, ElAbd R, Lalonde D, Williams J

Hand (N Y), 2024 Sep;19(6):865-874.

PMID: 36856295 DOI: 10.1177/15589447231153175

BACKGROUND: Metastatic lesions to the hand or wrist are rare and can mimic inflammatory and benign processes such as gout and infections. This often leads to misdiagnosis, underreporting, and delays in treatment. The purpose of this study was to examine all known cases of metastasis to the hand or wrist available in the literature and to analyze demographic trends, metastasis characteristics, and clinical course, and provide recommendations for management.

METHODS: An online systematic review of MEDLINE, Embase, PubMed, and the Cochrane Library from inception to January 7, 2022, was completed. Studies outlining the care of a patient with acrometastases of the hand were included. Data extracted included age, sex, site of primary tumor and metastasis, presence of other metastases, time from primary diagnosis to acrometastasis diagnosis, misdiagnosis, treatment, and survival.

RESULTS: Between 1889 and present, 871 lesions were described in 676 patients who met the inclusion criteria. There was no predilection for hand dominance or site of previous trauma. The mean age among patients was 59.5 (1.5-91) years, and male sex was more common (64.6%). The most common primary cancer source was the lung (39.2%), followed by the kidney (10.8%). The distal phalanx was the most frequently cited tumor location (33.7%). Mean survival after diagnosis of acrometastasis was 6.3 months (0.25-50) ± 11.5 months.

CONCLUSION: Acrometastasis remains an uncommon presentation of metastatic disease with poor prognosis. Treatment currently focuses on pain management and optimizing functional outcomes. Our review led to the development of 7 treatment recommendations when managing these patients.

Matched MeSH terms: Lung Neoplasms/pathology; Lung Neoplasms/secondary

Fulltext Respiratory clinics: haemoptysis, breathlessness and chest pain in a 46-year-old man

Khajotia R

Malays Fam Physician, 2010;5(2):105-6.

PMID: 25606198

Matched MeSH terms: Lung Neoplasms

Fulltext Pulmonary resection for metastatic breast cancer

Gooi BH, Premnath N, Manjit S

Med J Malaysia, 2004 Mar;59(1):112-4.

PMID: 15535346

The management of pulmonary metastasis from breast carcinoma is challenging and often consists of palliation of symptoms. Surgical resection of pulmonary metastasis is considered inappropriate in view of the disseminated nature of the disease and limited life expectancy. It can however be a worthwhile option if imaging, including bone scans rule out metastatic disease in other part of the body. We report a patient with pulmonary metastasis from breast carcinoma who was successfully treated with pulmonary wedge resection of the metastatic lesion.

Matched MeSH terms: Lung Neoplasms/radiography; Lung Neoplasms/secondary*; Lung Neoplasms/surgery*

Fulltext eComment. Pulmonary metastasectomy of colorectal carcinoma in patients with intra-thoracic lymph node involvement: a step too far?

Sachithanandan A

Interact Cardiovasc Thorac Surg, 2015 Feb;20(2):221.

PMID: 25605822 DOI: 10.1093/icvts/ivu415

Matched MeSH terms: Lung Neoplasms/mortality*

Fulltext Leucocytosis in a case of Lung Cancer: Infection or Paraneoplastic Syndrome? - Dilemma in Diagnosis and Treatment

Pandit S, Choudhury S, Das SK, Nandi S

Med J Malaysia, 2012 Oct;67(5):542-4.

PMID: 23770881

A 65 year old male smoker was diagnosed with squamous cell carcinoma of upper lobe of the right lung complicated with Horner's syndrome and gradually increasing leucocytosis. Alhough the inflammatory biomarker level in serum was low, there was no definite way to determine the cause of the leucocytosis (whether infection or hematologic paraneoplastic syndrome). After empirical antibiotic therapy, his fever subsided but the leucocytosis persisted. It was difficult for us to take a decision regarding the priority of the treatment of infection or the lung cancer. Only after the first cycle chemotherapy, did the leucocytosis rapidly drop down. Normal serum procalcitonin level and quick response to chemotherapy indicated that leucocytosis was a manifestation of paraneoplastic syndrome. Treating the underlying cancer is the first step.

Matched MeSH terms: Lung Neoplasms*

Lung cancer and cigarette-smoking. A brief discussion, and consideration of possible risks in Malaya

WILLIAMS HI

Med J Malaya, 1962 Sep;17:41-3.

PMID: 14000869

Matched MeSH terms: Lung Neoplasms*

Fulltext Role of routine post-operative laryngeal endoscopic assessment after lung cancer surgery

Liam CK

Respirology, 2018 01;23(1):10-11.

PMID: 28901032 DOI: 10.1111/resp.13172

Matched MeSH terms: Lung Neoplasms*

Fulltext Screening for lung cancer in Malaysia: are we there yet?

Sachithanandan A, Badmanaban B

Med J Malaysia, 2012 Feb;67(1):3-6.

PMID: 22582540 MyJurnal

Matched MeSH terms: Lung Neoplasms/diagnosis*; Lung Neoplasms/epidemiology

Dyspnoea in young adults due to pulmonary lymphangitic carcinomatosis from gastric carcinoma

Liam CK, Looi LM, Pailoor J, Alhady SF

Ann Acad Med Singap, 1989 Nov;18(6):713-6.

PMID: 2624423

Three cases of progressive dyspnoea in young female adults due to pulmonary lymphangitic carcinomatosis are reported. The underlying primary neoplasm was gastric carcinoma in all 3 cases. The diagnosis was not suspected in 2 patients because of their young age.

Matched MeSH terms: Lung Neoplasms/complications; Lung Neoplasms/secondary*

Role of therapeutic agents on repolarisation of tumour-associated macrophage to halt lung cancer progression

Aldawsari HM, Gorain B, Alhakamy NA, Md S

J Drug Target, 2020 02;28(2):166-175.

PMID: 31339380 DOI: 10.1080/1061186X.2019.1648478

Tumour-associated macrophages (TAMs) represent as much as 50% of the solid mass in different types of human solid tumours including lung, breast, ovarian and pancreatic adenocarcinomas. The tumour microenvironment (TME) plays an important role in the polarisation of macrophages into the M1 phenotype, which is tumour-suppressive, or M2 phenotype, which is tumour promoting. Preclinical and clinical evidences suggest that TAMs are predominantly of the M2 phenotype that supports immune suppression, tumour growth, angiogenesis, metastasis and therapeutic resistance. Hence, significant attention has been focussed on the development of strategies for the modification of TAMs to halt lung cancer progression. The promotion of repolarisation from the M2 to the M1 subtype, or the prevention of M2 polarisation of TAMs in the stromal environment is potential approaches to reduce progression and metastasis of lung cancer. The focus of this article is an introduction to the development and evaluation of therapeutic agents that may halt lung cancer progression via the manipulation of macrophage polarisation. This article will address recent advances in the therapeutic efficacy of nanomedicine exploiting surface functionalisation of nanoparticles and will also consider future perspectives.

Matched MeSH terms: Lung Neoplasms/drug therapy*; Lung Neoplasms/pathology

Single-cell RNA sequencing in human lung cancer: Applications, challenges, and pathway towards personalized therapy

Chong ZX, Ho WY, Yeap SK, Wang ML, Chien Y, Verusingam ND, et al.

J Chin Med Assoc, 2021 Jun 01;84(6):563-576.

PMID: 33883467 DOI: 10.1097/JCMA.0000000000000535

Lung cancer is one of the most prevalent human cancers, and single-cell RNA sequencing (scRNA-seq) has been widely used to study human lung cancer at the cellular, genetic, and molecular level. Even though there are published reviews, which summarized the applications of scRNA-seq in human cancers like breast cancer, there is lack of a comprehensive review, which could effectively highlight the broad use of scRNA-seq in studying lung cancer. This review, therefore, was aimed to summarize the various applications of scRNA-seq in human lung cancer research based on the findings from different published in vitro, in vivo, and clinical studies. The review would first briefly outline the concept and principle of scRNA-seq, followed by the discussion on the applications of scRNA-seq in studying human lung cancer. Finally, the challenges faced when using scRNA-seq to study human lung cancer would be discussed, and the potential applications and challenges of scRNA-seq to facilitate the development of personalized cancer therapy in the future would be explored.

Matched MeSH terms: Lung Neoplasms/drug therapy; Lung Neoplasms/genetics*

Feasibility of manual bronchial branch reading technique in navigating conventional rEBUS bronchoscopy in the evaluation of peripheral pulmonary lesion

Kho SS, Nyanti LE, Chai CS, Chan SK, Tie ST

Clin Respir J, 2021 Jun;15(6):595-603.

PMID: 33113256 DOI: 10.1111/crj.13297

BACKGROUND: Although radial endobronchial ultrasound (rEBUS) is an important verification tool in guided bronchoscopy, a navigational route was not provided. Manual airway mapping allows the bronchoscopist to translate the bronchial branching in computed tomography (CT) into a comparable bronchoscopic road map. We aimed to explore the feasibility of this technique in navigating conventional rEBUS bronchoscopy in the localisation of peripheral pulmonary lesion by determining navigation success and diagnostic yield.

METHODS: Retrospective review of consecutive rEBUS bronchoscopy performed with a 6.2 mm conventional bronchoscope navigated via manual bronchial branch reading technique over 18 months.

RESULTS: Ninety-eight target lesions were included. Median lesion size was 2.67 cm (IQR 2.22-3.38) with 96.9% demonstrating positive CT bronchus sign. Majority (86.7%) of lesions were situated in between the third and fifth airway generations. Procedure was performed with endotracheal intubation in 43.9% and fluoroscopy in 72.4%. 98.9% of lesions were successfully navigated and verified by rEBUS following the pre-planned airway road map. Bidirectional guiding device was employed in 29.6% of cases. Clinical diagnosis was secured in 88.8% of cases, majority of which were malignant disease. The discrepancy between navigation success and diagnostic yield was 10.1%. Target PPL located within five airway generations was associated with better diagnostic yield (95.1% vs. 58.8%, P

Matched MeSH terms: Lung Neoplasms*

Giant cell carcinoma of the lung. A case report

TOCK PC

Med J Malaya, 1962 Mar;16:219-24.

PMID: 13921481

Matched MeSH terms: Lung Neoplasms*

Anaesthetic problems of space-occupying lesions of the chest

Manavalan AS

Med J Malaya, 1969 Dec;24(2):124-7.

PMID: 4244137

Matched MeSH terms: Lung Neoplasms*

Displaying publications 1 - 20 of 311 in total